A5047040892- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genomic variations and chromosomal abnormalities
- IgG4-Related and Inflammatory Diseases
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Genomics and Chromatin Dynamics
- Galectins and Cancer Biology
- Actinomycetales infections and treatment
- 14-3-3 protein interactions
Yeungnam University Medical Center
2016-2023
Yeungnam University College
2017-2022
Yeungnam University
2017-2022
Weatherford College
2019
Seoul National University Bundang Hospital
2014-2017
Konkuk University
2015-2016
Seoul National University
2012-2015
New Generation University College
2015
Seoul National University Hospital
2012
Dankook University Hospital
2003
Tumour-infiltrating lymphocytes (TILs) are known to be associated with response primary systemic therapy (PST) in breast cancer. This study was conducted assess the association of TIL subsets pathological complete (pCR) after PST cancer relation subtype, stem cell (BCSC) phenotype and epithelial–mesenchymal transition (EMT). The pre-chemotherapeutic biopsy specimens 153 patients who underwent surgical resection anthracycline- or anthracycline/taxane-based were analysed. (CD4+, CD8+, FOXP3+...
Epidermal growth factor receptor (EGFR) is overexpressed in a subset of human epidermal 2 (HER2)-positive breast cancers, and coexpression HER2 EGFR has been reported to be associated with poor clinical outcome. Moreover, interaction between suggested possible basis for trastuzumab resistance. We analysed the significance overexpression gene copy number alterations 242 HER2-positive primary cancers. In addition, we examined correlations overexpression, response outcome 447 primary, 112...
Heterogeneity of HER2 gene amplification is found in a subset breast cancers. We investigated the impact heterogeneity on trastuzumab responses and clinical outcomes 112 patients with HER2-positive metastatic cancer.Regional genetic was determined three different areas each tumor by immunohistochemistry silver situ hybridization. also assessed overall levels proportion cells HER2/CEP17 ratio more than 2.2 or strong complete membranous (3+) expression protein.HER2 regional based confirmed...
Tumor-associated macrophages (TAMs) are involved in tumor progression by promoting epithelial-mesenchymal transition (EMT), cell invasion, migration and angiogenesis. However, breast cancer, the clinical relevance of TAM infiltration according to distinct histologic locations (intratumoral vs. stromal) hormone receptor status is unclear. We investigated significance levels invasive cancer. also examined relationship with clinicopathologic features tumors, expression EMT markers, outcomes....
// Jae Moon Gwak 1, 2 , Milim Kim 3 Hyun Jeong Min Hye Jang 4 So Yeon Park 1 Department of Pathology, Seoul National University College Medicine, Seoul, Republic Korea Green Cross Laboratory, Yongin, Bundang Hospital, Seongnam, Yeungnam Medical Center, Daegu, Correspondence to: Park, email: sypmd@snu.ac.kr Keywords: Oct4, breast cancer, cancer stem cell, prognosis, tamoxifen resistance Received: September 20, 2016 Accepted: March 21, 2017 Published: 31, ABSTRACT The transcription factors...
Abstract Introduction Gene amplification is an important mechanism for activating oncogenes in malignant tumors. Although of HER2 , C-MYC CCND1 and FGFR1 has been reported breast cancers, their role the progression situ to invasive carcinoma unclear. To investigate this question we compared frequencies these genes pure ductal (DCIS), DCIS associated with carcinoma, carcinoma. Methods We performed fluorescence hybridization selected on tissue microarrays composed 179 438 carcinomas. Two...
The role of telomerase reverse transcriptase (TERT) promoter mutations in differentiated thyroid cancer has been well established. These have a significantly higher prevalence aggressive tumors, including widely invasive oncocytic carcinomas, poorly and anaplastic carcinomas. Interestingly, some studies, TERT were found to be more common tumors with BRAF(V600E) mutation. However, mutational analysis not previously performed for patients Korea, where the mutation papillary carcinoma (PTC) is...
In spite of the usefulness Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability measurement absence standard method interpretation. This study was designed compare two methods assessing LI: average vs. hot spot thus determine which is more appropriate predicting prognosis luminal/HER2-negative cancers. LIs were calculated by direct counting three representative areas 493 cancers using methods. We...
Epidermal growth factor receptor (EGFR) is considered a potential therapeutic target for anti-EGFR therapy in triple-negative breast cancer (TNBC). However, the frequency of EGFR gene mutation TNBC low and varies with ethnicity. This study aimed to investigate incidence TNBC.EGFR protein expression was evaluated by immunohistochemistry tissue microarrays 493 cases using four different primary antibodies, which included mutation-specific antibodies. For an immunoreactivity level ≥1+, we...
Breast cancer stem cells (BCSCs) have been suggested to clinical implications for therapeutics because of their proposed role in chemoresistance. The aim this study was investigate the impact BCSC marker expression on outcome and trastuzumab response human epidermal growth factor receptor 2 (HER2)-positive breast cancer.We analysed markers, CD44+/CD24- aldehyde dehydrogenase 1 (ALDH1), outcomes three sets cases: Set 1, 242 HER2-positive primary cancers treated by various modalities; 2, 447...
Background: As measurement of Ki-67 proliferation index is an important part breast cancer diagnostics, we conducted a multicenter study to examine the degree concordance in counting and find factors that lead its variability.Methods: Thirty observers from thirty different institutions reviewed Ki-67-stained slides 20 cancers on whole sections tissue microarray (TMA) by online system.Ten had hot spots expression.Each observer scored two ways: direct (average vs. spot method) categorical...
To investigate whether there is a relationship between texture analysis parameters of apparent diffusion coefficient (ADC) maps and histopathologic features MCF-7 MDA-MB-231 xenograft models. estradiol (+), (-), models were made with approval the animal care committee. Twelve tumors 9 6 in included. Diffusion-weighted MR images obtained on 9.4-T system. An first second order ADC was performed. The compared among these groups by variance test. Correlations analyzed. We also evaluated...
A subpopulation of breast cancer cells with cluster differentiation (CD)44-positive and CD24-negative expression has been reported to have stem cell properties a higher tumorigenic capacity than other cells. However, the clinicopathological characteristics this are not fully understood. In study, we aimed identify correlations between CD44 CD24 parameters overall survival. We studied specimens from 262 patients invasive cancer. Immunohistochemical staining for was performed using tissue...
Caroli's disease (CD) is a rare congenital disorder characterized by non-obstructive segmental saccular dilatation of the large intrahepatic bile ducts.1 Two forms CD have been described. The pure type cystic ducts, while complex - also designated syndrome associated with hepatic fibrosis (CHF) and autosomal recessive polycystic kidney disease.2,3,4 usually affects liver diffusely but some localized (monolobar CD) affect only single lobe, predominantly left lobe.5,6 Complications are...
In patients with colorectal cancer (CRC), the BRAF V600E mutation has been reported to be associated several clinicopathological features and poor survival.However, prognostic implications of characteristics in CRCs remain controversial.Therefore, we reviewed various features, including status, 349 primary analyzed relationship between status factors, overall survival.Similar previous studies conducted Eastern countries, incidence current study was relatively low (5.7%).BRAF-mutated CRC...
Chromosomal instability (CIN) is known to be associated with prognosis and treatment response in breast cancer. This study was conducted determine whether copy number gain of centromere 17 (CEP17) reflects CIN, evaluate the prognostic predictive value CIN status determined by summing gains four centromeric probes (CEP1, CEP8, CEP11, CEP16) based on fluorescence situ hybridization scores were calculated using next generation sequencing data. High adverse clinicopatholgical parameters Among...
Background: Radial probe endobronchial ultrasound-guided transbronchial lung biopsy (RP-EBUS-TBLB) has improved the diagnostic yield of bronchoscopic peripheral pulmonary lesions (PPLs). The and complications RP-EBUS-TBLB for PPLs vary depending on technique, such as using a guide sheath (GS) or fluoroscopy. In this study, we investigated utility GS without fluoroscopy diagnosing PPLs.Methods: We retrospectively reviewed data from 607 patients who underwent RP-EBUS January 2019 to July 2020....
SMARCA4-deficient undifferentiated tumors (SMARCA4-DUTs) present with diverse clinical manifestations and progress to metastasis even cause death within a few months. This novel subset of occurs in the middle-aged population is strongly associated smoking history. Distinguishing it from other malignancies challenging.A 62-year-old man presented chest pain for 7 d. The patient had no respiratory symptoms normal pulmonary function test results. been smoker 8 years quit 2 ago. Chest computed...