A5069973820- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Ultrasonics and Acoustic Wave Propagation
- Flow Measurement and Analysis
- Engineering Applied Research
- Colorectal Cancer Surgical Treatments
- Eosinophilic Esophagitis
- Bacterial Genetics and Biotechnology
- Gastroesophageal reflux and treatments
- Genetic factors in colorectal cancer
- Cellular transport and secretion
- Structural Health Monitoring Techniques
- Gallbladder and Bile Duct Disorders
- Craniofacial Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Biliary and Gastrointestinal Fistulas
- Connective tissue disorders research
- Liver Disease and Transplantation
- Network Traffic and Congestion Control
Seoul National University Bundang Hospital
2009-2024
MSD (South Korea)
2021-2024
Iowa State University
2017-2023
Soongsil University
2005-2023
Soonchunhyang University
2010-2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019
Soonchunhyang University Hospital
2001-2018
University of California Davis Medical Center
2010-2017
Kyung Hee University
2017
University of California, Davis
2008-2015
The myristoylated alanine-rich protein kinase C substrate (MARCKS) is a major cellular of (PKC), and PKC phosphorylation produces translocation MARCKS from membrane to cytoplasm in many cells. Our working hypothesis that binding biological membranes requires both hydrophobic insertion its myristoyl chain into the lipid bilayer electrostatic interaction basic domain with acidic lipids. We tested this by measuring murine large unilamellar phospholipid vesicles (LUVs). estimated partition...
Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the development of pathogenic anti-RNA autoantibodies both systemic lupus erythematous (SLE) patients and murine models lupus. It is still unclear, however, where how TLR7-mediated interactions affect autoreactive B cells. We found that overexpression TLR7 transgenic mice (TLR7.1Tg) leads to marked alterations transitional (T1) cells, associated with their expansion proliferation within splenic red pulp (RP)....
Mutant forms of presenilin (PS) 1 and 2 amyloid precursor protein (APP) lead to familial Alzheimer's disease. Several reports indicate that PS may modulate APP export from the endoplasmic reticulum (ER). To develop a test this possibility, we reconstituted capture PS1 in COPII (coat complex II) vesicles formed ER membranes permeabilized cultured cells. The recombinant mammalian proteins were active reaction measures coat subunit assembly coated vesicle budding on chemically defined synthetic...
AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection saline alone for large colon polyps by conventional polypectomy.
Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions in a variety of clinical conditions, but studies concerning the practical impact CE on tumors are still scarce, especially Asian population. The aim this study was evaluate diagnostic and therapeutic field tumors.CE records consecutively pooled from beginning use Korea, October 2001 until April 2008, 14 centers throughout Korea were reviewed. Clinical information video images analyzed.A total 1332 cases...
The clinical impact of video capsule endoscopy (VCE) in patients with obscure gastrointestinal bleeding (OGIB) remains undetermined. aim this study was to evaluate the long-term VCE OGIB using a nationwide registry.Data from 305 who underwent for 13 hospitals Korea between January 2006 and March 2009 were analyzed. Prospectively collected registry data reviewed, follow-up by chart review telephone interviews patients. Multivariate regression analyses hazard ratios (HR) performed determine...
Boyadjiev SA, Kim S‐D, Hata A, Haldeman‐Englert C, Zackai EH, Naydenov Hamamoto S, Schekman RW, J. Cranio‐lenticulo‐sutural dysplasia associated with defects in collagen secretion. (CLSD) is a rare autosomal recessive syndrome manifesting large and late‐closing fontanels calvarial hypomineralization, Y‐shaped cataracts, skeletal defects, hypertelorism other facial dysmorphisms. The CLSD locus was mapped to chromosome 14q13‐q21 homozygous SEC23A F382L missense mutation identified the original...
With advances in diagnostic endoscopy, the detection of rectal neuroendocrine tumors (NETs) has increased. However, clinical outcomes, especially after endoscopic treatment, are still unclear. The aim this study was to determine long-term outcomes endoscopically resected NETs according pathologic status initial resection.In large, multicenter, retrospective cohort study, we analyzed medical records patients who underwent resection and were followed for ≥24 months at 16 university hospitals....
γ-Secretase is responsible for proteolytic maturation of signaling and cell surface proteins, including amyloid precursor protein (APP). Abnormal processing APP by γ-secretase produces a fragment, Aβ42, that may be Alzheimer's disease (AD). The biogenesis trafficking this important enzyme in relation to aberrant Aβ not well defined. Using cell-free reaction monitor the exit cargo proteins from endoplasmic reticulum (ER), we have isolated transient intermediate γ-secretase. Here, provide...
COPII proteins are essential for exporting most cargo molecules from the endoplasmic reticulum. The membrane-facing surface of (especially SEC23-SEC24) interacts directly or indirectly with destined exit. As we characterized SEC23A mutations at SEC31 binding site identified patients cranio-lenticulo-sutural dysplasia, discovered that SEC23-SEC31 interface can also influence selection. Remarkably, M702V does not compromise assembly, vesicle size, and packaging into vesicles have tested but...
Currently, the videofluoroscopic swallowing study (VFSS) is standard tool for evaluating dysphagia. We evaluated whether addition of endoscopist-directed flexible endoscopic evaluation (FEES) to VFSS could improve detection rates penetration, aspiration, and pharyngeal residue, compared diagnostic efficacy between FEES assessed adverse events FEES.In single tertiary referral center, a retrospective analysis prospectively collected data was conducted. Fifty consecutive patients suspected...
Capsule endoscopy (CE) is widely used. However, CE has limitations including incomplete examination, inadequate bowel preparation, and retention. The aim of this study was to estimate the indications for detection, completion, retention rates small intestine based on 10-year data from Korean Endoscopy Registry.Twenty-four hospitals participated in study. Clinical information, such as reasons CE, method quality examination capsule rates, collected analyzed.A total 2,914 CEs were registered....
To date, high-resolution manometry has been used mainly in the study of esophageal motility disorders and shown to provide more physiological information than conventional manometry, is easier interpret. This aimed evaluate usefulness anorectal (HRARM) compared water-perfused manometry.Patients who complained chronic constipation with/without fecal incontinence underwent both HRARM a random order on same day. Resting squeezing pressures anal sphincter, attempted defecation, rectoanal...