A5081586719- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Mesenchymal stem cell research
- Esophageal and GI Pathology
- Gut microbiota and health
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Gastroesophageal reflux and treatments
- Cancer Cells and Metastasis
- Diverticular Disease and Complications
- IL-33, ST2, and ILC Pathways
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Metabolism, Diabetes, and Cancer
Ewha Womans University
2016-2025
Ewha Womans University Medical Center
2015-2024
Yonsei University
2005-2018
Suwon Research Institute
2016
Kangbuk Samsung Hospital
2013-2015
Sungkyunkwan University
2013-2015
Catholic Kwandong University
2010-2014
Yahoo (United Kingdom)
2013
Washington University in St. Louis
2013
Myongji Hospital
2011-2012
Abstract Lactobacillus paracasei is a major probiotic and well known for its anti-inflammatory properties. Thus, we investigated the effects of L. -derived extracellular vesicles (LpEVs) on LPS-induced inflammation in HT29 human colorectal cancer cells dextran sulfate sodium (DSS)-induced colitis C57BL/6 mice. ER stress inhibitors (salubrinal or 4-PBA) CHOP siRNA were utilized to investigate relationship between LpEV-induced endoplasmic reticulum (ER) inhibitory effect LpEVs against...
Colorectal cancer (CRC) is the third most common form of and poses a critical public health threat due to global spread westernized diets high in meat, cholesterol, fat. Although link between diet colorectal has been well established, mediating role gut microbiota remains elusive. In this study, we sought elucidate connection microbiota, diet, CRC through metagenomic analysis bacteria isolated from stool (n = 89) healthy 161) subjects. This yielded dozen genera that were significantly...
<h3>Background and Aims</h3> To identify the associations of genetic epigenetic variations in <i>IL-23R</i> <i>IL-17A</i> with inflammatory bowel diseases (IBD). <h3>Methods</h3> The promoter exon regions were analysed 727 subjects (201 Crohn9s disease, 268 ulcerative colitis 258 healthy controls) using DNA sequencing denaturing high performance liquid chromatography. Transcription factor binding affinity, mRNA expression methylation evaluated peripheral blood mononuclear cells (PBMC) Jurkat...
Cancer stem cells (CSCs) play a pivotal role in cancer relapse or metastasis. We investigated the CSC-suppressing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and relevant mechanisms colorectal cancer. measured NSAIDs on CSC populations Caco-2 SW620 using colosphere formation flow cytometric analysis PROM1 (CD133)(+) CD44(+) after indomethacin treatment with/without prostaglandin E2 (PGE2) peroxisome proliferator-activated receptor γ (PPARG) antagonist, examined transcriptional...
Background: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal disease (GERD).We aimed to evaluate prevalence risk for RE GERD determine whether gender specific differences exist.Methods: This study was conducted on a health cohort consisting 10,158 participants who underwent comprehensive screening.Lifestyles gastrointestinal symptoms were investigated using self-reported structured questionnaire.Questionnaires...
With advances in diagnostic endoscopy, the detection of rectal neuroendocrine tumors (NETs) has increased. However, clinical outcomes, especially after endoscopic treatment, are still unclear. The aim this study was to determine long-term outcomes endoscopically resected NETs according pathologic status initial resection.In large, multicenter, retrospective cohort study, we analyzed medical records patients who underwent resection and were followed for ≥24 months at 16 university hospitals....
Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with evaluate impact on clinical course a Korean CD patient cohort. We performed multicenter retrospective analysis 1,047 registered Disease Clinical Network Cohort study Korea. The mean interval was 16.0 ± 33.1 months. Multivariate showed that older age at diagnosis (≥40 years)...
Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Seong Jung Hyun Gun Sung Noh Hong, Eun Sun Chang Mo Moon, Dae Myung, Dong-Hoon Baek, Shin Ju Oh, Lee, Ji Yunho Jung, Jaeyoung Chun, Yang, Ran Intestinal Tumor Research Group of the Korean Association for Study Diseases (KASID). Gut and Liver -0001;0:. https://doi.org/10.5009/gnl240217
Abstract Background Inflammatory Bowel Disease (IBD) is characterized by chronic intestinal inflammation driven a complex interplay of genetic, environmental, and immune interactions1. Despite significant advancements in IBD therapies, many patients still face challenges achieving complete remission or maintaining long-term treatment efficacy. We hypothesize that extracellular vesicles from Bifidobacterium longum subspecies infantis (B. infantis-EVs) can regulate responses, promote balanced...
Abstract Background and Aim: 18 F‐Fluoro‐2‐deoxy‐ d ‐glucose positron emission tomography ( FDG‐PET) is promising for diagnosis treatment of various malignancies. The aim this study was to evaluate the clinical usefulness FDG‐PET in differential staging cholangiocarcinomas according intrahepatic, perihilar common bile duct lesions compare with computerized (CT) scan. Methods: From January 2000 September 2003, 54 patients suspected cholangiocarcinoma underwent abdominal CT scan within a...
Abstract Background and Aim Prior studies have reported 2‐ L polyethylene glycol ( PEG ) plus ascorbic acid + A sc) is an effective alternative to standard 4‐ for bowel preparation before colonoscopy, but they are limited because of some confounders. Therefore, we compared the efficacy, patient compliance, satisfaction, safety Asc versus cleansing in optimal strategies. Methods In this prospective, randomized, single‐blind trial, consenting outpatients were randomly assigned one two arms....
Goals: To investigate the association between treatment nonadherence and patients' knowledge of prescribed medication among individuals with inflammatory bowel disease (IBD), evaluate impact on relapse. Background: The patient's has been identified as an important predictor adherence in chronic diseases. However, this not examined IBD. Study: In prospective study, at baseline, 138 patients IBD completed a self-reported survey demographic data, medication, candidate factors related to degree...
Abstract This study aimed to investigate the correlations between diffuse splenic Fluorine-18-fluorodeoxyglucose ( 18 F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) and inflammatory markers evaluate prognostic significance of FDG in rectal cancer patients who underwent curative surgery. We retrospectively analyzed data from 161 PET/CT staging subsequent surgical resection July 2006 September 2014. The spleen-to-liver ratio (S/L ratio) was calculated by dividing...
Background/Aims: To compare the clinical features and disease behavior of ulcerative colitis (UC) according to age at onset. Methods: This retrospective study included 455 patients with UC who were diagnosed treated between 1990 2008 a single tertiary institution in Korea. The divided into 2 groups their diagnosis UC: an elderly group (≧40 years) young (<40 years). Clinical findings diagnosis, extent disease, treatment modalities used, cumulative admission rates, relapse surgery rates...
The incidence of treatment failure or recurrence Clostridium difficile-associated diarrhea (CDAD) following metronidazole has increased recently. We studied the failure, rate, and risk factors predictive after for CDAD.We retrospectively identified consecutive patients who were admitted treated CDAD at a single tertiary institution in Korea over recent 10-year period (i.e., 1998-2008).Metronidazole was administered as initial to 111 117 (94.9%) with CDAD. Fourteen (12.6%) had no clinical...
Recent European ancestry genome-wide association studies have identified genetic variants of IRGM as significant susceptibility loci for Crohn's disease (CD). Therefore, we investigated whether confer to CD or ulcerative colitis (UC) and evaluated the genotype-phenotype associations in Korean population.This study included 510 inflammatory bowel (IBD) patients (253 with 257 UC) 520 healthy controls Koreans. Initially, performed direct sequencing analysis identify unique single nucleotide...
Abstract Background and Aims: Silent gastroesophageal reflux disease (GERD) is often detected during routine screening esophagogastroduodenoscopy (EGD). However, the risk factors clinical implications of silent GERD remain unclear. In present study, we investigated for asymptomatic erosive esophagitis by analyzing local area health examination data. Methods: The Korean National Health Insurance Corporation provides a bi‐annual performed qualified hospitals early detection cancer in medical...
Background/Aims Inflammatory bowel disease (IBD) is a chronic disabling gastrointestinal disorder that diminishes the quality of life affected individuals. Limited data are available regarding impact IBD on daily Koreans. Methods Self-administered, computer-aided, internet-based questionnaires were distributed to members Korean patient organization for from March April 2013, by Association Study Intestinal Diseases. Results A total 599 patients with (387 Crohn's [CD] and 212 ulcerative...
Since colon cancer stem cells (CSCs) play an important role in chemoresistance and tumor recurrence metastasis, targeting of CSCs has emerged as a sophisticated strategy for therapy. α-mangostin (αM) been confirmed to have antiproliferative apoptotic effects on cells. This study aimed evaluate the selective inhibition αM colorectal (CRC) suppressive effect 5-fluorouracil (5-FU)-induced CSCs.The cell viability assay was performed determine optimal concentration αM. A sphere forming flow...
The incidence of colorectal cancer (CRC) and preinvasive CRC (