A5041865193- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Electronic Health Records Systems
- Gastrointestinal motility and disorders
- Cancer Genomics and Diagnostics
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Mobile Health and mHealth Applications
- Esophageal and GI Pathology
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Clinical Nutrition and Gastroenterology
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2017-2023
Weatherford College
2022
Samsung (India)
2022
Samsung (United States)
2022
Inha University Hospital
2020
Nankai University
2016
Korea University
2010-2016
National University College
2014
Crohn's disease (CD) and ulcerative colitis (UC) are considered rare diseases in developing countries. We have evaluated the incidence prevalence of CD UC over time a district Seoul, Korea.A population-based study was performed from 1986 to 2005 Songpa-Kangdong Seoul. To recruit patients as completely possible, multiple information sources, including all medical facilities area 3 referral centers nearby but outside area, were used.During 20-year period, 138 incident cases (102 men, 36 women)...
In the human DNA mismatch repair (MMR) system, hMSH2 forms hMutSα and hMutSβ complexes with hMSH6 hMSH3, respectively, whereas hMLH1 hPMS2 form hMutLα heterodimer. These complexes, together other components in MMR correct single-base mismatches small insertion/deletion loops that occur during replication. Microsatellite instability (MSI) occurs when microsatellites are not corrected because of a malfunctioning system. Low-frequency MSI (MSI-L) is seen some chronically inflamed tissues...
Steady-state levels of human DNA mismatch repair (MMR) transcripts and proteins were measured in MMR-proficient -deficient cell lines by the newly developed competitive quantitative reverse transcription- polymerase chain reaction Western analysis normalized with purified proteins. In cells, hMSH2 is most abundant MMR protein expressed 3 to 5 times more than hMLH1. The hMLH1 was 1.5 2.5 hPMS2. mRNA expression correlated well expression. hMSH2-mutated LoVo cells did not express detectable...
Abundant recent data suggest that sessile serrated adenoma/polyp (SSA/P) is an early precursor lesion in the pathway of carcinogenesis. It believed SSA/Ps develop cancer by SSA/P-dysplasia-carcinoma sequence. Hyperplastic polyps (HPs) share some histologic and molecular characteristics with SSA/P, but it unclear whether are derived from HPs or they a different pathogenetic pathway. Previous studies have shown Korean patients show prevalence rates certain abnormalities compared similar...
Abstract Background and Aims : Ulcerative colitis (UC) is regarded as a rare disease in developing countries, but accurate data are generally lacking. We performed the present study to evaluate incidence prevalence of UC Korea. Methods A retrospective was from 1986 1997 Songpa‐Kangdong district Seoul, To recruit patients completely possible, multiple information sources including all medical facilities area three referral centres located nearby, outside were used. The rates adjusted using...
The pathogenesis and risk of malignancy traditional serrated adenomas (TSAs) are unclear. In North America, TSAs relatively uncommon, occur mainly in the left colon, some studies, have not been shown to a strong association with hyperplastic polyp (HPP) or sessile adenoma (SSA) precursor lesions. Far East, particularly Korea, more common both right colon. However, Korean patients, similarity those that never evaluated. purpose this study was determine frequency type lesion TSAs, molecular...
Preparation regimens for morning colonoscopy are suboptimal. The aim of this study was to test the efficacy and tolerance a split-dose magnesium citrate-low-volume (2 liters) polyethylene glycol (PEG) regimen colonoscopy.A total 232 patients were randomly assigned receive 4 liters PEG (day before procedure; group 1, n=79), 2 procedure) followed by another 2, n=80), or citrate (250 ml, day 3, n=73). quality bowel cleansing, tolerability, adverse effects in 3 compared with those groups 1...
There is suggestive but sparse evidence that dyslipidemia associated with colorectal neoplasms. We investigated the association of serum lipid and apolipoprotein concentrations prevalence adenomas.Cross-sectional study 19,281 consecutive participants aged 40-79 years undergoing screening colonoscopy at Center for Health Promotion Samsung Medical in Korea from January 2006 to June 2009.We identified 5,958 adenomas (30.9%), including 5,504 (28.5%) non-advanced 454 (2.4%) advanced adenomas. The...
Abstract Background Colorectal carcinoma (CRC) with CpG island methylator phenotype (CIMP) is recognized as a distinct subgroup of CRC, and CIMP status affects prognosis response to chemotherapy. Identification in CRC important for proper patient management. In Eastern countries, however, the clinicopathologic molecular characteristics CRCs are still unclear. Methods A total 245 patients who underwent their first surgical resection sporadic were enrolled was determined using quantitative...
Although recent studies have reported that inflammatory bowel disease [IBD] is associated with the development of neurodegenerative diseases via chronic intestinal inflammation and gut-brain axis, there insufficient evidence supporting this notion. The aim study was to determine risk including Parkinson's [PD] Alzheimer's [AD] in patients IBD.Using National Health Insurance Service data for entire Korean population, we identified IBD controls from 2009 2011 followed them up until 2017. We...
Abstract Background and Aim: To perform endoscopic mucosal resection (EMR) for T1 esophageal cancer, it is essential to estimate the lymph node status exactly. In order evaluate feasibility of EMR cancers, we evaluated clinicopathological features squamous carcinomas with an emphasis on risk factors distribution patterns metastasis. Methods: From 1994 2006, a total 200 patients carcinoma were treated surgically in our institution. Among them, 197 consecutive cell carcinoma. Results: The...
Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions in a variety of clinical conditions, but studies concerning the practical impact CE on tumors are still scarce, especially Asian population. The aim this study was evaluate diagnostic and therapeutic field tumors.CE records consecutively pooled from beginning use Korea, October 2001 until April 2008, 14 centers throughout Korea were reviewed. Clinical information video images analyzed.A total 1332 cases...