A5101676772- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Minimally Invasive Surgical Techniques
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Diverticular Disease and Complications
- Cancer, Lipids, and Metabolism
- Anorectal Disease Treatments and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- Economic and Financial Impacts of Cancer
- Surgical Simulation and Training
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
Inje University Haeundae Paik Hospital
2025
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
Electronics and Telecommunications Research Institute
2010-2024
Yonsei University
2024
Samsung (South Korea)
2015-2021
Inje University Sanggye Paik Hospital
2021
The Linguistic Society of Korea
2021
University of Seoul
2018
CHA Gangnam Medical Center
2016
Accurate detection of genomic alterations using high-throughput sequencing is an essential component precision cancer medicine. We characterize the variant allele fractions (VAFs) somatic single nucleotide variants and indels across 5095 clinical samples profiled a custom panel, CancerSCAN. Our results demonstrate that significant fraction clinically actionable have low VAFs, often due to tumor purity treatment-induced mutations. The percentages mutations under 5% VAF hotspots in EGFR, KRAS,...
This study aimed to assess the performance of ChatGPT, specifically GPT-3.5 and GPT-4 models, in understanding complex surgical clinical information its potential implications for education training.The dataset comprised 280 questions from Korean general surgery board exams conducted between 2020 2022. Both models were evaluated, their performances compared using McNemar test.GPT-3.5 achieved an overall accuracy 46.8%, while demonstrated a significant improvement with 76.4%, indicating...
The role of the radiofrequency ablation (RFA) in treatment solitary liver metastasis has not been established yet. Both hepatic resection (HR) and RFA have used increasingly colorectal metastases.A systemic review was performed to determine impact modality on recurrence patterns, disease-free survival, overall survival (OS) rates.Solitary metastases were treated by HR 116 patients (75.8%) 37 (24.2%) with RFA. Prognostic factors, rate, rates analyzed. cumulative 3-year 5-year local free...
Mucinous adenocarcinoma (MAC) is a histological subtype of colorectal cancer. The oncologic behavior MAC differs from nonmucinous (non-MAC). Our aim in this study was to characterize patients with through evaluation large, institutional-based cohort long-term follow-up. A total 6475 stages I III cancer who underwent radical surgery were enrolled January 2000 December 2010. Prognostic comparison between (n = 274, 4.2%) and non-MAC performed. median follow-up period 48.0 months. Patients...
Anastomotic leakage (AL) is one of the most serious complications colorectal surgery. It can affect long-term oncologic outcomes, but impact on survival remains uncertain. The aim this study to evaluate operative characteristics and no groups analyze outcomes. We prospectively enrolled 10,477 patients from 2000 2011 retrospectively reviewed data. Male sex (odds ratio [OR], 3.90; P < 0.001), intraoperative transfusion (OR, 2.31; = 0.042), time 1.73; 0.032) were independent risk factors AL in...
Chemokine ligand 7 (CCL7) enhances cancer progression and metastasis via epithelial-mesenchymal transition (EMT). However, little is known about the molecular mechanism of CCL7-induced EMT signaling cascade in colon cancer. Thus, objective this study was to investigate pathway its role To demonstrate effect CCL7 on induction, HCT116 HT29 cells overexpressing were generated. downstream evaluated by both vitro vivo experiments. In studies, found interplay with CC chemokine receptor 3 (CCR3),...
Abstract Although stromal fibroblasts play a critical role in cancer progression, their identities remain unclear as they exhibit high heterogeneity and plasticity. Here, master transcription factor (mTF) constructing core-regulatory circuitry, PRRX1 , which determines the fibroblast lineage with myofibroblastic phenotype, is identified for subgroup. orchestrates functional drift of into phenotype via TGF-β signaling by remodeling super-enhancer landscape. Such reprogrammed have functions...
The most reliable prognostic factor in colon cancer is the TNM classification. objective of this study was to assess and compare role tumor-infiltrating lymphocytes (TILs) stage II cancer.Immunohistochemistry used density TILs that were positive for cluster differentiation 3 (CD3) (T-cell coreceptor), CD45 isoform RO (CD45RO) (protein tyrosine phosphatase), nuclear transcription forkhead box P3 (FOXP3), CD25 (a type I transmembrane protein) according tumor site (intraepithelial stromal)...
Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In study, we compared paired primary and metastatic colorectal cancer samples determine whether heterogeneity can predict metastasis.Experimental Design: Somatic variations 46 pairs of matched primary-liver tumors 42 without metastasis were analyzed by whole-exome sequencing. Tumor clonality was estimated from single-nucleotide copy-number variations....
// Seung Tae Kim 1, * , Won-Suk Lee 2, Richard B. Lanman 3 Stefanie Mortimer Oliver A. Zill Kyoung-Mee 4, 5 Kee Taek Jang Seok-Hyung Se Hoon Park 1 Joon Oh 4 Young Suk Ho Yeong Lim Helmy Eltoukhy Won Ki Kang Woo Yong 6 Hee-Cheol Keunchil Jeeyun AmirAli Talasaz Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea 2 Surgery, Gil Gachon University, Incheon, Guardant Health Inc., Redwood City, CA, USA The Innovative Cancer...
Abstract Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the utility estimating tumor using targeted panel data. We investigated prognostic impact (TH) index on outcomes, mutational profiles from data acquired 1,352 patients across 8 types. The TH...
The prognostic role of surgical resection primary tumors is not well established in patients with asymptomatic unresectable stage IV colorectal cancer.The aims this study were to reveal the and define factors affecting long-term oncological outcomes synchronous metastases.This was a retrospective analysis prospectively collected data.Between 2000 2008, total 416 cancer analyzed propensity score matching.Prematching baseline characteristics compared by bivariate analysis, 113 pairs selected...
There is ongoing debate about the appropriate criterion for defining a positive circumferential resection margin after radical surgery rectal cancer.The purpose of this work was to determine importance extent with regard outcomes in patients cancer who underwent total mesorectal excision and without neoadjuvant chemoradiotherapy.This retrospective review prospectively collected data.The study conducted tertiary care hospital.We reviewed medical charts 780 from 2004 2009. were 599 (76.8%) did...
<b><i>Purpose:</i></b> The epithelial-mesenchymal transition (EMT) is known to be associated with tumor progression, invasion and metastasis in colorectal cancer (CRC). <b><i>Materials Methods:</i></b> Tissue samples obtained from 409 patients stage III CRC treated 2006 2007 were examined by immunohistochemistry reveal the expression levels of E-cadherin, fibronectin, vimentin α-smooth muscle actin (SMA)....
// Bo Young Oh 1,* , Woo Yong Lee 1,2,* Sungwon Jung 3 Hye Kyung Hong 1 Do-Hyun Nam 2,4 Yoon Ah Park Wook Huh Seong Hyeon Yun Hee Cheol Kim Ho-Kyung Chun 5 and Beom Cho 1,2,6 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School Medicine, Seoul, Korea 2 Health Sciences Technology, SAIHST, University, Genome Medicine Science, Graduate Gachon Incheon, 4 Neurosurgery, Kangbuk Hospital, 6 Device Management Research, * These authors have contributed equally to this work...