A5103129573- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Diverticular Disease and Complications
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Metastasis and carcinoma case studies
- S100 Proteins and Annexins
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- Cancer, Lipids, and Metabolism
Kangbuk Samsung Hospital
2013-2022
Sungkyunkwan University
2013-2022
DuPage Health Coalition
2016
Samsung Medical Center
2002-2013
Korea Research Institute of Bioscience and Biotechnology
2010
George Washington University
1995
Washington University Medical Center
1995
Abstract Purpose: To identify epigenetic molecular makers in plasma for the early detection of colorectal cancer. Experimental Design: We retrospectively analyzed methylation status 10 genes fresh-frozen tissues and corresponding samples from 243 patients with stage I II sporadic cancer, 276 healthy individuals, 64 adenoma using methylation-specific PCR. The score (Mscore) was used to find markers high sensitivity specificity. Results: Of cancer tissues, detected 18% p14, 34% p16, 27% APC,...
The role of the radiofrequency ablation (RFA) in treatment solitary liver metastasis has not been established yet. Both hepatic resection (HR) and RFA have used increasingly colorectal metastases.A systemic review was performed to determine impact modality on recurrence patterns, disease-free survival, overall survival (OS) rates.Solitary metastases were treated by HR 116 patients (75.8%) 37 (24.2%) with RFA. Prognostic factors, rate, rates analyzed. cumulative 3-year 5-year local free...
In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits NOSES including reduction postoperative pain and wound complications, less use analgesic, faster recovery bowel function, shorter length hospital stay, better cosmetic psychological effect have been described surgery. Despite significant decrease surgical trauma observed, pitfalls this technique demonstrated. Particularly,...
Mucinous adenocarcinoma (MAC) is a histological subtype of colorectal cancer. The oncologic behavior MAC differs from nonmucinous (non-MAC). Our aim in this study was to characterize patients with through evaluation large, institutional-based cohort long-term follow-up. A total 6475 stages I III cancer who underwent radical surgery were enrolled January 2000 December 2010. Prognostic comparison between (n = 274, 4.2%) and non-MAC performed. median follow-up period 48.0 months. Patients...
PURPOSE: Postoperative ileus contributes to surgical morbidity and is associated with prolonged hospitalization increased health care costs. The efficacy safety of the peripherally acting μ-opioid receptor antagonist methylnaltrexone in shortening duration postoperative following segmental colectomy was evaluated. METHODS: Two identically designed, multicenter, double-blind, parallel-group, placebo-controlled studies randomly assigned patients undergoing (study 1, N = 515; study 2, 533)...
The prognostic role of surgical resection primary tumors is not well established in patients with asymptomatic unresectable stage IV colorectal cancer.The aims this study were to reveal the and define factors affecting long-term oncological outcomes synchronous metastases.This was a retrospective analysis prospectively collected data.Between 2000 2008, total 416 cancer analyzed propensity score matching.Prematching baseline characteristics compared by bivariate analysis, 113 pairs selected...
There is ongoing debate about the appropriate criterion for defining a positive circumferential resection margin after radical surgery rectal cancer.The purpose of this work was to determine importance extent with regard outcomes in patients cancer who underwent total mesorectal excision and without neoadjuvant chemoradiotherapy.This retrospective review prospectively collected data.The study conducted tertiary care hospital.We reviewed medical charts 780 from 2004 2009. were 599 (76.8%) did...
<b><i>Purpose:</i></b> The epithelial-mesenchymal transition (EMT) is known to be associated with tumor progression, invasion and metastasis in colorectal cancer (CRC). <b><i>Materials Methods:</i></b> Tissue samples obtained from 409 patients stage III CRC treated 2006 2007 were examined by immunohistochemistry reveal the expression levels of E-cadherin, fibronectin, vimentin α-smooth muscle actin (SMA)....
// Bo Young Oh 1,* , Woo Yong Lee 1,2,* Sungwon Jung 3 Hye Kyung Hong 1 Do-Hyun Nam 2,4 Yoon Ah Park Wook Huh Seong Hyeon Yun Hee Cheol Kim Ho-Kyung Chun 5 and Beom Cho 1,2,6 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School Medicine, Seoul, Korea 2 Health Sciences Technology, SAIHST, University, Genome Medicine Science, Graduate Gachon Incheon, 4 Neurosurgery, Kangbuk Hospital, 6 Device Management Research, * These authors have contributed equally to this work...
The introduction of complete mesocolic excision (CME) with central vessel ligation (CVL) for right-sided colon cancer has improved oncologic outcomes. However, there is controversy over the safety laparoscopic CME CVL. This study compared short-term and long-term outcomes between open modified (mCME) CVL in patients cancer.We enrolled 1239 who underwent mCME 1010 treated by a approach right-side 2000 2013 used 1:1 propensity score matching to adjust potential baseline confounders two...
Local recurrence of rectal cancer is difficult to treat, may cause severe and disabling symptoms, usually has a fatal outcome. The aim this study was document the clinical nature locally recurrent determine effect surgical resection on long-term survival. A retrospective review conducted prospectively collected medical records 2485 patients with primary adenocarcinoma who underwent radical between September 1994 December 2008. In total, 147 (5.9%) exhibited local recurrence. most common type...
This study was designed to evaluate the characteristics of recurrences that occur five or more years after curative resection for colorectal cancer.This included a total 352 patients who were confirmed as having recurrence cancer during period from January 1995 December 2000. Of patients, 231 had early (less than 2 operation), 103 intermediate (2-5 and 18 late (more 5 operation). The clinicopathologic findings with compared those other two groups, special reference pattern recurrence.The...
Previously, we reported that overexpression of Opa (Neisseria gonorrhoeae opacity-associated)-interacting protein 5 (OIP5) caused multi-septa formation and growth defects, both which are considered cancer-related phenotypes. To evaluate OIP5 as a possible cancer therapeutic target, examined its expression level in 66 colorectal patients. was upregulated about 3.7-fold tumors over 2-fold 58 out Knockdown by small interfering RNA specific to (siOIP5) resulted inhibition gastric cell lines....
Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor (TFPI2 ), N-Myc downstream-regulated gene 4 (NDRG4) and bone morphogenic 3 (BMP3), have previously been shown to be hypermethylated colorectal cancer (CRC). We aim examine cancerization CRC based on the presence of aberrant normal-appearing from patients.We investigated promoter 34 patients five individuals with...