A5066826242- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Chronic Kidney Disease and Diabetes
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- Diverticular Disease and Complications
- Dialysis and Renal Disease Management
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Acupuncture Treatment Research Studies
- Minimally Invasive Surgical Techniques
- Anorectal Disease Treatments and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Brain Metastases and Treatment
- Metastasis and carcinoma case studies
- Circular RNAs in diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Shanxi Medical University
2023-2024
National Cancer Centre Japan
2024
National Clinical Research
2022-2024
Beijing Children’s Hospital
2024
Capital Medical University
2022-2024
Army Medical University
2012-2024
Xinqiao Hospital
2014-2024
Yahoo (United Kingdom)
2023
Tianjin Chest Hospital
2021
Left ventricular hypertrophy (LVH) is a common complication in patients with CKD and an independent risk factor for death. Changes the levels of uremic solutes or Klotho have been reported to be related CKD, whereas relationships between these factors CKD-associated LVH remain unclear. Here, we investigated interaction indoxyl sulfate (IS), typical solute, LVH. In survey 86 negative relationship was found serum IS (r=−0.59, P<0.001). Furthermore, were independently associated (for IS:...
In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits NOSES including reduction postoperative pain and wound complications, less use analgesic, faster recovery bowel function, shorter length hospital stay, better cosmetic psychological effect have been described surgery. Despite significant decrease surgical trauma observed, pitfalls this technique demonstrated. Particularly,...
Abstract Increased basic fibroblast growth factor‐2 ( FGF2 ) and reduced Klotho have both been reported to be closely associated with renal fibrosis. However, the relationship between remains unclear. We demonstrate that induced tubulo‐epithelial plasticity in cultured HK ‐2 cells, accompanied by a reduction expression, whereas recombinant protein could inhibit action of . The effects required extracellular signal‐regulated kinase 1/2 activation, which was suppressed Klotho. Moreover, also...
MicroRNA-93 (miR-93) is involved in several carcinoma progressions. It has been reported that miR-93 acts as a promoter or suppressor different tumors. However, till now, the role of colon cancer unclear. Herein, we have found expression was lower human tissue and colorectal cell lines compared with normal mucosa. Forced cells inhibits invasion, migration, proliferation. Furthermore, may downregulate Wnt/β-catenin pathway, which confirmed by measuring level β-catenin, axin, c-Myc, cyclin-D1...
Apolipoprotein E (ApoE) plays a key role in tumorigenesis and progression, such as cell proliferation, angiogenesis metastasis. ApoE overexpression was associated with aggressive biological behaviors poor prognosis variety of tumor according to previous studies. This study aimed assess the prognostic value explore potential relationship progression colorectal cancer (CRC). We collected expression profiling microarray data from Gene Expression Omnibus (GEO), investigated pattern between...
<h3>Importance</h3> Radiotherapy is a common treatment for rectal cancer, yet the risk of second gynecological malignant neoplasms (SGMNs) in patients with cancer undergoing radiotherapy have not been adequately studied. <h3>Objective</h3> To investigate association between and individual types SGMN assess survival outcomes. <h3>Design, Setting, Participants</h3> A large population-based cohort study was designed to identify SGMNs diagnosed from January 1973 December 2015. The statistical...
Ischemic-reperfusion injury (IRI) is a major pathogenic factor in acute kidney (AKI), which directly leads to the hypoxic of renal tubular epithelial cells (RTECs). Although emerging studies suggest repressor element 1–silencing transcription (REST) as master regulator gene repression under hypoxia, its role AKI remains elusive. Here, we found that REST was upregulated patients, mice, and RTECs, positively associated with degree injury, while tubule–specific knockout Rest significantly...
Although the recommended minimal examined lymph node (ELN) number in rectal cancer (RC) is 12, this standard remains controversial because of insufficient evidence. We aimed to refine definition by quantifying relationship between ELN number, stage migration and long-term survival RC.Data from a Chinese multi-institutional registry (2009-2018) Surveillance, Epidemiology, End Results (SEER) database (2008-2017) on stages I-III resected RC were analysed determine count, migration, overall (OS)...
To investigate the role of miR-450b-5p, a newly identified microRNA, located in Xq26 region, development chemoresistance colorectal cancer (CRC), and to explore underlying mechanism by which miR-450b-5p regulates this process. In study, we demonstrated that expression was downregulated recurrent CRC tissues. We found significantly inhibited response 5-fluorouracil (5-FU) treatment HT-29 cells HCT-116 cells. Importantly, overexpression 5-FU-resistant reduced cell viability, but elevated DNA...
Natural orifice specimen extraction has been shown to reduce postoperative pain and wound complications, provide better cosmetic outcome. However, whether transvaginal affects sexual function remains controversial. The purpose of this study was investigate the short-term outcomes, function, outcomes prognosis after colon cancer surgery with extraction.This a propensity score-matched comparative retrospective study, based on prospectively collected data in single center. This included 70...
Abstract Objective This study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes tumour immune microenvironment. Methods Data expression and READ were obtained from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Bioinformatics analysis explored correlation between TTN cell infiltration. In vitro, lentiviral vectors used to assess mutations' effects ANKRD1 two lines. was...
At present, natural orifice specimen extraction surgery (NOSES) has attracted more and attention worldwide, because of its great advantages including minimal cutaneous trauma post-operative pain, fast recovery, short hospital stay, positive psychological impact. However, NOSES for the treatment gastric cancer (GC) is still in infancy, there potential to improve theoretical system clinical practice. Especially, several key points oncological outcomes, bacteriological concerns, indication...
Abstract Although the occurrence of tumour deposits (TDs) without metastatic lymph nodes (mLNs) is classified as “N1c” in 8 th TNM staging system for colorectal cancer (CRC), prognostic significance TD count still controversial. A total 39155 CRC patients were collected from Surveillance, Epidemiology, and End Results (SEER) database. The potential associations between baseline characteristics status evaluated using χ 2 test. Cancer-specific survival (CSS) rates calculated by Kaplan-Meier...
p50-associated cyclooxygenase-2 extragenic RNA (PACER) is a recently identified antisense long non-coding (lncRNA) located on the upstream of promoter region (COX-2). Preliminary studies have suggested that PACER involved in regulation COX-2 expression macrophagocyte and osteosarcoma cells. However, role this lncRNA colorectal cancer (CRC) remains elusive. Here, we investigated its effect cell proliferation invasion to explore CRC. Real-time quantitative PCR (RT-qPCR) analysis was used...
Background: Acute kidney injury (AKI) occurs in approximately 7-18% of all hospitalizations, but there are currently no effective drug therapy for preventing AKI or delaying its progression to chronic disease (CKD). Recent studies have shown that Scutellaria baicalensis, a traditional Chinese herb, could attenuate cisplatin-induced AKI, although the mechanism remains elusive. Further, it is unknown whether major active component, Oroxylin A (OA), can alleviate injury. Methods: The...