A5100377151- Genetic Associations and Epidemiology
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Gene expression and cancer classification
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Plant biochemistry and biosynthesis
- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Cancer, Hypoxia, and Metabolism
- Plant Gene Expression Analysis
- Plant Pathogens and Fungal Diseases
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Chromosomal and Genetic Variations
- Wnt/β-catenin signaling in development and cancer
- Peroxisome Proliferator-Activated Receptors
Nationwide Children's Hospital
2017-2024
Chinese Academy of Sciences
2019-2024
Sichuan Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Institute of Urban Environment
2024
Hebei Normal University of Science and Technology
2022-2024
Shanghai University of Medicine and Health Sciences
2024
Liaoning Normal University
2024
Hangzhou Center for Disease Control and Prevention
2024
The Ohio State University
2014-2023
The majority of children with Dravet syndrome (DS) are caused by de novo SCN1A mutations. To investigate the origin mutations, we developed and applied a new method that combined deep amplicon resequencing Bayesian model to detect quantify allelic fractions improved sensitivity. Of 174 mutations in DS probands which were considered "de novo" Sanger sequencing, identified 15 cases (8.6%) parental mosaicism. We another five mosaicism also detectable sequencing. Fraction mutant alleles 20...
Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, proliferation, and cytokine production. Epigenetic control genome also governs cell transcriptome lineage commitment maintenance. Cellular programs interact with epigenetic regulation by providing substrates for covalent modifications chromatin. By using complementary genetic, epigenetic, approaches, we revealed that tricarboxylic acid (TCA) cycle flux fueled biosynthetic...
Apolipoprotein E (ApoE) plays a key role in tumorigenesis and progression, such as cell proliferation, angiogenesis metastasis. ApoE overexpression was associated with aggressive biological behaviors poor prognosis variety of tumor according to previous studies. This study aimed assess the prognostic value explore potential relationship progression colorectal cancer (CRC). We collected expression profiling microarray data from Gene Expression Omnibus (GEO), investigated pattern between...
<h3>Importance</h3> Little is known about the association of trimethylamine<i>N</i>-oxide (TMAO), a novel plasma metabolite derived from L-carnitine and phosphatidylcholine, related metabolites (ie, choline, betaine, carnitine, butyrobetaine) with risk death among older adults in general population. <h3>Objective</h3> To investigate associations serial measures TMAO total cause-specific deaths cardiovascular diseases [CVDs] non-CVDs) US. <h3>Design, Setting, Participants</h3> This...
Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little the mechanisms that govern heterogeneity tumor cells nor role plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms—it exhibits widespread inter- intra-tumoral heterogeneity, predictable patterns metastasis, a lack clear targetable driver mutations. Understanding...
Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale found to play critical roles. However, clinically unremarkable individuals, pSNMs never identified largely due technical difficulties lack of matched control tissue samples, thus the genome-wide characteristics remain unknown. We developed new Bayesian-based mosaic genotyper series effective error filters, using which we were able identify 17 SNM sites...
Abstract Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage. The aggressive alveolar subtype characterized by t(2;13) or t(1;13) translocations encoding for PAX3- PAX7-FOXO1 chimeric transcription factors, respectively, and are referred to as fusion positive RMS (FP-RMS). gene alters the myogenic program maintains proliferative state while blocking terminal differentiation. Here, we investigated contributions chromatin regulatory complexes FP-RMS tumor maintenance....
Recent characterizations of pioneer transcription factors provide insights into their structures and patterns chromatin recognition associated with roles in cell fate commitment transformation. Intersecting these basic science concepts, identification (PFs) fused together as driver translocations childhood cancers raises questions whether fusions retain the fundamental ability to invade repressed chromatin, consistent monomeric PF constituents. This study defines cellular localization...
Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure function are plausible neurobiological characterisation schizophrenia. However, the effects schizophrenia on these imaging endophenotypes not yet been fully elucidated. Aims To investigate risk for grey matter volume functional connectivity, which disrupted in Method Genomic data from large sample Han...
To identify a glycolysis-related gene signature for the evaluation of prognosis in patients with breast cancer, we analyzed data training set from TCGA database and four validation cohorts GEO ICGC databases which included 1,632 cancer. We conducted GSEA, univariate Cox regression, LASSO, multiple regression analysis. Finally, an 11 - related to glycolysis predicting survival cancer was developed. And Kaplan–Meier analysis ROC analyses suggested that showed good prognostic ability BC TCGA,...
One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in biosynthetic needs unchecked proliferation, abrogating cell death programs, and immunologic escape. However, mechanism metabolic switch not fully understood. Here, we found that S-nitrosoproteomic profile endogenous nitrogen oxide ovarian cancer cells targeted multiple components processes. Phosphofructokinase (PFKM), one most important regulatory enzymes glycolysis, was S-nitrosylated...
Abstract Background Breast cancer is regarded as a heterogeneous disease with four molecular subtypes. However, the clinicopathological characteristics among different subtypes have not been studied in Chinese demographic. This study clarifies prevalence and features of each subtype investigates independent prognosis factors population. Methods A retrospective review 1,820 breast women were classified into based on IHC‐based definitions for ER, PR, HER‐2/neu to evaluate prognosis. Results...
Introgression of genomic variation between and within related crop species is a significant evolutionary approach for population differentiation, genome reorganization trait improvement. Using the Illumina Infinium Brassica 60K SNP array, we investigated changes in panel advanced generation new-type napus breeding lines developed from hundreds interspecific crosses 122 rapa 74 carinata accessions, compared them with representative accessions their three parental species. The B. presented...
RUNX3 (runt-related transcription factor-3) has been reported to suppress tumor tumorigenesis and metastasis in different human cancers. In this study, we used tissue microarray (TMA) determine the significance of prostate cancer progession. Our results showed ectopic expression tissues when compared with adjacent normal tissues, reduced staining was significantly correlated TNM stage. Moreover, demonstrated that overexpression inhibited cell migration invasion resulting from elevated...
Aerobic glycolysis plays a decisive role in cancer growth. However, its metastasis was rarely understood. Cantharidin natural compound from an arthropod insect cantharis exerts potent anticancer activity. Here we found cantharidin possesses significant anti-metastatic activity on breast dependent inhibition of aerobic glycolysis. indicates migration and invasion cells, angiogenesis vitro, inhibits cells metastasizing to liver lung vivo. Subsequent results revealed that decreases the...
Abstract Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence a chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses amino-terminal domain EWS to carboxyl-terminus FLI. portion intrinsically disordered transcriptional regulatory domain, while FLI contains ETS DNA-binding two flanking regions unknown function. Early studies using non-Ewing models provided conflicting information on roles each in EWS/FLI oncogenic We...
We demonstrate that loss of succinate dehydrogenase 5 (SDH5) expression initiates epithelial-mesenchymal transition (EMT), which is visualized by the repression E-cadherin and up-regulation vimentin in lung cancer cell lines clinical specimens. In SDH5 knock-out mice, epithelial cells exhibited elevated mesenchymal markers, characteristic EMT. Using a human xenograft-mouse model, we observed knocking down endogenous carcinoma leads to development multiple lymph node metastases. Moreover, our...
Schizophrenia, major depressive disorder, and bipolar disorder are three psychiatric disorders affecting around 0.66%, 3.3%, 1.5% of the Han Chinese population respectively. Several genetic linkage analyses genome wide association studies identified NRG1 as a susceptibility gene schizophrenia, which was validated by its role in neurodevelopment, glutamate, other neurotransmitter receptor expression regulation. To further investigate whether is shared risk for well we performed an study among...