A5089050869- Veterinary Oncology Research
- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Microbial infections and disease research
- Veterinary Medicine and Surgery
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Biochemical and Structural Characterization
- Animal Genetics and Reproduction
- Human-Animal Interaction Studies
- Infectious Diseases and Mycology
- Amoebic Infections and Treatments
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Agriculture Sustainability and Environmental Impact
- Urological Disorders and Treatments
- Medical Imaging and Pathology Studies
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Pediatric Urology and Nephrology Studies
- Protease and Inhibitor Mechanisms
The Ohio State University
2019-2024
Nationwide Children's Hospital
2020-2023
Augsburg University
2014-2021
University of Minnesota
2017-2021
Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little the mechanisms that govern heterogeneity tumor cells nor role plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms—it exhibits widespread inter- intra-tumoral heterogeneity, predictable patterns metastasis, a lack clear targetable driver mutations. Understanding...
OBJECTIVE To describe cytologic characteristics of renal fine-needle aspirate (FNA) samples from dogs, evaluate proportions specimens deemed adequate for interpretation (diagnostic yield), assess diagnostic utility examination neoplastic and nonneoplastic diseases, characterize ultrasonographic features evaluated kidneys to determine whether the imaging could be used inform interpretations. DESIGN Retrospective, observational study. SAMPLE 102 97 studies 100 dogs. PROCEDURES Medical records...
Abstract Purpose For patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared many solid tumors. While established metastatic lesions behave aggressively, very few of the tumor cells that reach will survive. By identifying mechanisms facilitate survival disseminated cells, we can develop therapeutic strategies prevent and treat metastasis. Methods We analyzed single cell RNA-sequencing (scRNAseq) data murine metastasis-bearing lungs to...
Objectives The primary objective of this study was to retrospectively assess the diagnostic utility feline renal fine-needle aspiration cytology by assessing yield, cytologic characteristics and accuracy. secondary characterize ultrasonographic features sampled kidneys determine if they influenced yield. Methods Slides, images patient data were collected from University Minnesota Veterinary Medical Center database. Slides designated as or non-diagnostic. Non-diagnostic slides used in...
Abstract Background Enzymatic activity of Te lomerase R everse T ranscriptase (TERT) is important in maintaining the telomere length and has been implicated cancer aging related pathology. Since susceptibility as well longevity dogs vary between breeds, this study involved sequencing entire TERT gene Canis familiaris from DNA samples obtained forty dogs, with ten each four breeds: Shih Tzu, Dachshund, Irish Wolfhound, Newfoundland, different life expectancies to cancer. Results We compared...
Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little the mechanisms that govern heterogeneity tumor cells nor role plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms—it exhibits widespread inter- intra-tumoral heterogeneity, predictable patterns metastasis, a lack clear targetable driver mutations. Understanding...
Urothelial carcinoma, also known as transitional cell is the most common primary bladder tumour in dogs, and can involve prostate gland. Cytology a diagnostic tool utilized for dogs with or gland lesions. The objectives of this retrospective study were to compare sensitivity specificity cytologic evaluation urothelial prostatic carcinoma between two institutions different cytology review protocols well determine if certain collection methods resulted higher accuracy. A total 298 cases met...
Abstract A 6‐year‐old 21.5 kg castrated male Siberian Husky was presented for acute onset of lethargy, vomiting, hemorrhagic diarrhea, and inappetence. Physical examination revealed marked discomfort upon abdominal palpation 5%–7% dehydration. The CBC biochemical profile changes consistent with mild to moderate inflammation, dehydration, gastrointestinal (GI) disease. Despite aggressive support, anorexia persisted, an upper GI endoscopy performed in conjunction esophagostomy tube placement....
A 13-year-old 4.6 kg castrated male Italian Greyhound was presented for evaluation of sneezing, bilateral epistaxis and mucoid nasal discharge approximately 3 months duration. Severe periodontal disease noted on physical exam. The patient's CBC unremarkable. His biochemical profile revealed mild azotemia as well electrolyte abnormalities. Rhinoscopy a tan plaque present in the left dorsal meatus cavity. Vigorous flushing yielded granular white particulates suspended saline, which were...
The authors have indicated that they no affiliations or financial involvement with any organization entity a interest in, in competition with, the subject matter materials discussed this article.
Abstract We sought to identify dependencies of slow growing, chemo-resistant osteosarcoma cells that anchor in the metastatic niche. These yield insight into what allows early survive hostile lung environment, as well potential therapeutic targets. In our studies colonization, we identified two distinct populations cells. The first, dubbed “anchor cells”, are prevalent niche where they hypo-proliferative and hyper-secretory. second subpopulation, “growth proliferate rapidly predominate...
Abstract Purpose For patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared many solid tumors. While established metastatic lesions behave aggressively, very few of the tumor cells that reach will survive. By identifying mechanisms facilitate survival disseminated cells, we can develop therapeutic strategies prevent and treat metastasis. Methods We analyzed single cell RNA-sequencing (scRNAseq) data murine metastasis-bearing lungs to...
Abstract The adhesion protein L-selectin (CD62L) is expressed at high levels by circulating neutrophils and has a critical role in initiating their recruitment sites of inflammation. expression rapidly downregulated upon neutrophil activation various stimuli through proteolytic process referred to as ectodomain shedding, which regulates L-selectin’s binding avidity recruitment. In humans mice, shedding primarily mediated ADAM17 (a disintegrin metalloproteinase 17). also canine activation;...
In collaboration with the American College of Veterinary Pathologists.
In collaboration with the American College of Veterinary Pathologists.