A5021494615- Cancer Genomics and Diagnostics
- Nutrition and Health in Aging
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Immune cells in cancer
- Cardiac pacing and defibrillation studies
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- 3D Printing in Biomedical Research
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Ubiquitin and proteasome pathways
- Shoulder Injury and Treatment
- GDF15 and Related Biomarkers
Medical University of South Carolina
2022-2024
Nationwide Children's Hospital
2020
Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little the mechanisms that govern heterogeneity tumor cells nor role plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms—it exhibits widespread inter- intra-tumoral heterogeneity, predictable patterns metastasis, a lack clear targetable driver mutations. Understanding...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% patients. second cachexia, compromises treatment tolerance for patients and reduces their quality life. Although various mouse models exist, recapitulating both metastatic cachectic have been challenging. Methods Here, we optimize an orthotopic model by altering several conditions,...
SRY (sex determining region Y)-box 2 (SOX2)-labeled cells play key roles in chemoresistance and tumor relapse; thus, it is critical to elucidate the mechanisms propagating them. Single-cell transcriptomic analyses of most common malignant pediatric brain tumor, medulloblastoma (MB), revealed existence astrocytic
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to by exploring skeletal muscle, whose atrophy strongly poor outcomes. Using multiple mouse models patient samples, we show cachectic muscle marked enhanced innate immunity. Nuclear factor κB (NF-κB) activity in cells, including satellite...
Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little the mechanisms that govern heterogeneity tumor cells nor role plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms—it exhibits widespread inter- intra-tumoral heterogeneity, predictable patterns metastasis, a lack clear targetable driver mutations. Understanding...
Abstract Cancer cachexia is a debilitating syndrome characterized by unintentional weight loss largely due to the depletion of adipose and skeletal muscle mass. Cachexia occurs in at least half all patients with cancer, increasing incidences more advanced cases, estimated be responsible for greater than 20% cancer related deaths. In pancreatic ductal adenocarcinoma (PDAC), which has 5-year survival rate 13%, incidence can as high 80% associated poor disease outcomes. Mitigating effects...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor prognosis due to two key features. The first metastasis at presentation, occurring in approximately 80% of PDAC patients, 90% these metastases the liver. second cachexia, which compromises treatment tolerance and reduces quality life for patients. Although various mouse models exist, recapitulating both metastatic cachectic features have been challenging. In this study, we optimized an orthotopic model...
Abstract Medulloblastoma is the most common malignant pediatric brain tumor. Despite fair efficacy of current treatment approaches, 30 % patients with medulloblastoma relapse. Cells expressing stemness biomarker SRY (sex determining region Y)-box 2 (SOX2) are known to play key roles in sustaining growth, providing chemo-resistance, and driving tumor It therefore critical elucidate underlying mechanisms that propagate these cells ensure therapies target them. Single cell sequencing analyses...