A5043596097- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Product Development and Customization
- T-cell and Retrovirus Studies
- Quality Function Deployment in Product Design
- Manufacturing Process and Optimization
- Veterinary Oncology Research
- Design Education and Practice
- Air Traffic Management and Optimization
- Body Composition Measurement Techniques
- Probabilistic and Robust Engineering Design
- Advanced Aircraft Design and Technologies
- Bone health and osteoporosis research
- Advanced Multi-Objective Optimization Algorithms
- Human-Automation Interaction and Safety
- Head and Neck Cancer Studies
- Medical Imaging and Pathology Studies
- Service-Oriented Architecture and Web Services
- Ear and Head Tumors
- Heterotopic Ossification and Related Conditions
- Software System Performance and Reliability
- Advanced Software Engineering Methodologies
- Infectious Diseases and Mycology
- Abdominal Trauma and Injuries
- Simulation Techniques and Applications
The Ohio State University
2016-2023
Marine Mammal Center
2023
MBio Diagnostics (United States)
2023
Columbus Zoo and Aquarium
2023
Loyola Marymount University
2020-2023
Pennsylvania State University
2002
Northeastern University
2000-2002
Universidad del Noreste
2000
In an effort to increase customization for today’s highly competitive global markets, many companies are looking product families variety and shorten lead-times while reducing costs. The key a successful family is the common platform around which derived. Building on our previous work in design, we introduce penalty function (PFPF) this paper aid selection of scaling parameters products derived from scalable platforms. implementation PFPF utilizes powerful physical programming paradigm...
In response to today's highly competitive global marketplace, many companies are utilizing product families - groups of related products derived from a platform maintain economies scale while satisfying variety customer requirements. This paper focuses on scale-based and presents new single-stage approach for simultaneously optimizing the resulting family based one or more scaling variables that used instantiate by "stretching" "shrinking" it in dimensions satisfy The proposed is also unique...
An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), endemic areas of infection in Japan, Australia, the Caribbean, and Africa. HTLV-1 is causative agent adult (ATL) associated myopathy/tropic spastic paraparesis (HAM/TSP). expresses several regulatory accessory genes that function at different stages life cycle. The gene Tax-1 required for efficient replication, as it drives transcription viral products, has also been demonstrated to...
Abstract Background Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult leukemia/lymphoma (ATL) and neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact mechanism(s) through which latency disease progression are regulated not fully understood. CCCTC-binding factor (CTCF) an 11-zinc finger, sequence-specific, DNA-binding protein with thousands binding sites throughout mammalian genomes. CTCF has been shown to play a role...
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes an aggressive malignancy and variety of inflammatory conditions. The integrated provirus includes single binding site for the epigenomic insulator, CCCTC-binding protein (CTCF), but its function remains unclear. In current study, mutant was examined eliminates CTCF-binding site. mutation did not disrupt kinetics levels gene expression, or establishment reactivation from latency. However, disrupted epigenetic barrier...
Abstract In an effort to produce more variety for today’s highly competitive market, companies are designing and developing families of products — groups related derived from common product platforms simultaneously satisfy multiple customer requirements. After reviewing the state art in family platform design, we describe Product Platform Concept Exploration Method (PPCEM) that can be scaled or “stretched” into a suitable products. This paper extends previous work by authors through novel...
Complex design optimization problems, which involve many nonlinearly coupled objectives and constraints, pose considerable difficulties in the formulation of aggregate objective function. A representative example such a complex problem is aircraft structures based on strength, stiffness, manufacturability, cost requirements. An effective methodology for has recently been developed. This used to develop computational tool analysis primary structural components. wing spar was demonstrate...
Brimacomb, OE, Martinez, MP, McCormack, WP, and Almstedt, HC. A 2-year longitudinal study of bone mineral density in collegiate distance runners. J Strength Cond Res 37(8): 1654-1659, 2023-The purpose this investigation was to examine changes (BMD) male female runners over 2 years. Bone 29 (16 men 13 women) were measured 5 times 24 months using dual-energy x-ray absorptiometry (DXA) at the anterior-posterior (AP) lateral (LAT) spine, femoral neck (FN), total hip (TH), whole body (WB),...
Feline infectious peritonitis (FIP) is a systemic disease in felid species caused by infection with mutated forms of feline coronavirus (FCoV), and outbreaks can devastate exotic populations human care. was diagnosed three four related juvenile sand cats (Felis margarita) from single institution over 6-wk period. Case 1 7-mon-old male found deceased no premonitory signs. 2, an 8-mon-old (littermate to 1), 3, 6-mon-old (from different litter identical parentage), were evaluated for lethargy...
Case summary A 5-year-old female spayed domestic shorthair cat was presented with a 4.5 × 3 cm ulcerated cutaneous mass on the nasal bridge extension into cavity. Tissue biopsy obtained and diagnosis of large-cell lymphoma confirmed histopathology. The started prednisolone injectable chemotherapy; however, only partial response observed. CT scan revealed highly infiltrative extensive subcutaneous involvement, extending cavity, resulting in lysis numerous facial bones. received...
In an effort to increase customization for today's highly competitive global markets, many companies are looking product families variety and shorten lead-times while reducing costs. The key a successful family is the platform around which derived. Building on our previous work in design, we introduce penalty function (PFPF) this paper aid selection of common parameters scaling variables scaled-based products derived from platforms. implementation PFPF utilizes powerful physical programming...
Complex design optimization problems, which involve many nonlinearly coupled objectives and constraints, pose considerable difficulties in the formulation of aggregate objective function. A representative example such a complex problem is aircraft structures based on strength, stiffness, manufacturability, cost requirements. An effective methodology for has recently been developed. This used to develop computational tool analysis primary structural components. wing spar was demonstrate...
A 5‐year‐old pug presented with a soft tissue swelling on the ventral neck and moderate stridor associated respiratory effort. This patient received hypofractionated radiotherapy for metastatic upper lip mast cell tumour to submandibular lymph nodes 6 months before presentation. Oral examination showed elongation of palate, stage III laryngeal collapse only right saccule mildly everted exuberant pale epiglottal left pharyngeal mucosa. Staphylectomy, resection mucosa arytenoid lateralisation...
There have been few longitudinal studies beyond one year examining bone mineral density (BMD) in collegiate distance runners. Weight-bearing activity such as running tends to be osteogenic, however runners often experience injuries and may site-specific deficiencies compared norms. PURPOSE: Examine the BMD of Division I cross country across a two-year time frame. METHODS: 19 cross-country (12 men & 7 women) were measured via dual energy x-ray absorptiometry at beginning season for three...