Background Urine protein loss is common in dogs with chronic kidney disease ( CKD ). Hypothesis/Objectives To evaluate new biomarkers of glomerular and tubulointerstitial TI ) damage compared histology as survival indicators naturally occurring, proteinuric . Animals One hunderd eighty occurring disease. Methods Retrospective study using urine, serum, renal biopsies from disease, 91% which had Biomarkers were evaluated correlated pathologic damage, significant associations, sensitivities,...

There are many causes of kidney disease in dogs. The association the diagnostic category with survival is unknown. Determine outcomes for biopsy-determined categories Six hundred forty-nine dogs were biopsied evaluation disease. Retrospective study. Survival information was obtained whose biopsy submitted to International Veterinary Renal Pathology Service between 2008 and 2018. Signalment, serum creatinine (sCr), urine protein : ratio (UPCR), albumin (sAlb) reported at time biopsy. Cox...

Background Urine protein loss is common in dogs with chronic kidney disease ( CKD ). Currently available noninvasive means of evaluating cannot accurately predict the severity glomerular and tubulointerstitial damage. Electrophoretic analysis urine proteins can indicate compromised renal compartment (glomerular vs tubular), but extensive evaluation banding pattern associations histologic damage has not been performed dogs. Objectives We aimed to evaluate electrophoretic patterns as...

A 10 yr old domestic longhair presented with a 2.5 mo history of recurrent hematuria. Abdominal ultrasound examination demonstrated thickened urinary bladder, abdominal lymphadenopathy, and rounded spleen. Cytologic fine-needle aspirate samples revealed Histoplasma capsulatum organisms in the bladder wall The cat was treated itraconazole (10 mg/kg per os q 24 hr for wk). euthanized after 19 days treatment because lack improvement. To authors' knowledge, this is first documented case feline...

Abstract Dogs with X-linked hereditary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juvenile-onset renal failure. Their disease is analogous Alport syndrome in humans, and they also serve as good model of chronic kidney (CKD). However, the gene expression profile affects progression this has only been partially characterized. To help fill gap, we used RNA sequencing identify differentially expressed genes (DEGs), over-represented pathways, upstream...

Abstract Background Urine is routinely evaluated in dogs to assess health. Reference ranges for many urine properties are well established, but the scope of variation these over time within healthy not characterized. Objectives Longitudinally characterize 3 months. Animals Fourteen client‐owned dogs. Methods In this prospective study, were health; then, mid‐stream free‐catch was collected from each dog at 12 timepoints pH, specific gravity (USG), protein, cultures, and antimicrobial...

Abstract Background Focal segmental glomerulosclerosis (FSGS) is a common cause of nonimmune complex glomerulopathy and the prognosis clinicopathologic findings associated with this condition have not been described in dogs. Objective To characterize presentation identify clinical factors survival dogs FSGS. Animals Seventy‐seven diagnosed FSGS based on evaluation renal biopsy samples submitted to International Veterinary Renal Pathology Service. Methods Retrospective review medical records...

Abstract Background Most proteinuric dogs with naturally occurring chronic kidney disease have amyloidosis (AMYL), glomerulosclerosis (GS), or immune complex‐mediated glomerulonephritis (ICGN), each different treatment and prognosis. A noninvasive disease‐specific biomarker is lacking. Hypothesis We hypothesized that the expression pattern of biofluid microRNA (miRNAs miRs) would correlate progression categorization. Animals Archived serum urine samples from 18 glomerular 6 clinically...

Urothelial carcinoma, also known as transitional cell is the most common primary bladder tumour in dogs, and can involve prostate gland. Cytology a diagnostic tool utilized for dogs with or gland lesions. The objectives of this retrospective study were to compare sensitivity specificity cytologic evaluation urothelial prostatic carcinoma between two institutions different cytology review protocols well determine if certain collection methods resulted higher accuracy. A total 298 cases met...

Refractometry is utilized routinely to evaluate canine urine specific gravity (USG) in veterinary clinical settings. We aimed determine if the magnitude of interobserver reliability when assessing USG via refractometry could impact judgment. was determined 38 dogs by 3 registered technicians (RVTs) using both an optical analog refractometer and a digital refractometer. Summary statistics were reported, assessed intraclass correlation coefficient (ICC) analysis through 2-way mixed-effects...

The gut microbiome has emerged as a clear player in health and disease, part by mediating host response to environment lifestyle. urobiome (microbiota of the urinary tract) likely functions similarly. However, efforts characterize assess its functional potential have been limited due technical challenges including low microbial biomass high cell shedding urine. Here, begin addressing these challenges, we evaluate urine sample volume (100 ml - 5 mL), DNA depletion methods their effects on...

Abstract A 4‐year‐old male neutered domestic shorthair cat was presented to The Ohio State University College of Veterinary Medicine for a 2‐month history severe weight loss, lethargy, anemia, and bilaterally hyperechoic kidneys with loss corticomedullary distinction as reported by the referring veterinarian. Relevant initial laboratory results included non‐regenerative normocytic hypochromic increased blood urea nitrogen, minimally concentrated urine, proteinuria, an urine...

A 13-year-old 4.6 kg castrated male Italian Greyhound was presented for evaluation of sneezing, bilateral epistaxis and mucoid nasal discharge approximately 3 months duration. Severe periodontal disease noted on physical exam. The patient's CBC unremarkable. His biochemical profile revealed mild azotemia as well electrolyte abnormalities. Rhinoscopy a tan plaque present in the left dorsal meatus cavity. Vigorous flushing yielded granular white particulates suspended saline, which were...

Abstract A 6‐year‐old, spayed female, mixed shorthair cat presented to the emergency service at The Ohio State University Veterinary Medical Center for evaluation of hypercalcemia, a right eye mass, and multiple intrathoracic intra‐abdominal masses. Cytologic one abdominal masses revealed uniform population large, anaplastic mesenchymal cells found individually, in loose aggregates, occasionally associated with pink, extracellular matrix. cytology was consistent malignant neoplasm, primary...

Abdominal ultrasound with spleen and liver cytology is part of routine staging for canine mast cell tumors (MCTs). However, such tests are associated increased morbidity cost. Therefore, the objectives this study were to determine if was predictive in MCTs any patient or tumor variables and/or metastasis. Records dogs reviewed. Two hundred five patients included. Overall, 22 (10.7%) had metastasis, 21 (10.2%) 13 (6.3%) having respectively, 12 (5.9%) both. For a positive (or negative)...

A 7-year-old male castrated domestic shorthair cat presented with a 5-day history of inappetence. mid-abdominal mass was palpated and, on exploratory laparotomy, cystic arising from the root mesentery observed. The drained, debulked and omentalized. Histopathologic examination immunohistochemistry supported diagnosis hemangiosarcoma. Adjuvant doxorubicin started prior to third five doses doxorubicin, repeat abdominal ultrasound showed complete response primary tumor. Continued monitoring 240...

When a solitary liver mass is identified in dog, fine-needle aspirate (FNA) commonly employed to attempt obtain diagnosis. Little information provided the literature evaluating sensitivity/specificity of FNA cytology for masses. We hypothesized that lesion size nor presence cavitation would impact success cytological Medical records were obtained 220 client-owned dogs. Inclusion criteria included preoperative abdominal imaging, percutaneous hepatic with cytologic interpretation by...

Abstract Background Urine is routinely evaluated in dogs to assess health. Reference ranges for many urine properties are well established, but the scope of variation these over time within heathy not characterized. Objectives Longitudinally characterize healthy 3 months. Animals Fourteen client-owned dogs. Methods Dogs were health; then, mid-stream free catch was collected from each dog at 12 timepoints: Mornings / afternoons Days 1, 2, 3; end Weeks 4, 5, 6, 7 and Months 2 3. pH, specific...