A5014809042- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Bacterial Infections and Vaccines
- Veterinary Medicine and Surgery
- Inhalation and Respiratory Drug Delivery
- Liver Disease and Transplantation
- Intestinal and Peritoneal Adhesions
- Gastroesophageal reflux and treatments
- Metabolism and Genetic Disorders
- Alcoholism and Thiamine Deficiency
- Esophageal and GI Pathology
- Asthma and respiratory diseases
- Intestinal Malrotation and Obstruction Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Food Allergy and Anaphylaxis Research
- Veterinary Equine Medical Research
- Gastrointestinal disorders and treatments
- T-cell and B-cell Immunology
- Celiac Disease Research and Management
- IL-33, ST2, and ILC Pathways
- Bacillus and Francisella bacterial research
- Optical Imaging and Spectroscopy Techniques
- Immune Response and Inflammation
The Ohio State University
2018-2024
Cornell University
2024
Bile acids, produced by the liver and secreted into gastrointestinal tract, are dynamic molecules capable of impacting overall health dogs cats in many contexts. Importantly, gut microbiota metabolizes host primary bile acids chemically distinct secondary acids. This review explores emergence new literature connecting microbial-derived acid metabolism to canine feline disease. Moreover, this highlights multi-omic methodologies for translational research as an area continued growth veterinary...
Intestinal epithelial cells (IECs) are known to regulate allergic sensitization. We addressed the role of intrinsic IKKβ signaling in IECs effector phase allergy following oral allergen challenge and its impact on severity symptoms is poorly. Upon orally sensitization by co-administration ovalbumin with cholera toxin as adjuvant, wild-type mice lacking (IKKβΔIEC mice) developed similar levels serum IgE allergen-specific secretory IgA. However, subsequent challenges gut promoted reduced...
Background Microbial-derived secondary bile acids (SBAs) are reabsorbed and sensed via host receptors modulating cellular inflammation fibrosis. Feline chronic kidney disease (CKD) occurs with progressive renal fibrosis, mirroring the pathophysiology of human CKD patients. Methods Prospective cross-sectional study compared healthy cats ( n = 6) (IRIS Stage 2 17, 3 or 4 11). Single timepoint fecal samples from all underwent targeted acid metabolomics. 16S rRNA gene amplicon sequencing using...
It is well established that dendritic cells and macrophages play a role in antigen presentation to B T shaping cell responses via cytokines they produce. We have previously reported depletion of neutrophils improves the production mucosal IgA after sublingual immunization with Bacillus anthracis edema toxin as adjuvant. These past studies also demonstrated an inverse correlation exists between number by cells. Using specific inhibitors elastase, we addressed whether elastase activity...
Abstract Sublingual immunization is emerging as an alternative to nasal and induction of mucosal IgA responses. Using Bacillus anthracis edema toxin (EdTx) adjuvant, we previously showed that innate responses triggered after sublingual could limit generation We tested whether co-administration a neutrophil elastase inhibitor (NEI) rescue the ability EdTx induce broad antibody responses, including IgA. NEI supplementation vaccines containing promoted antigen-specific serum but also enhanced...
Refractometry is utilized routinely to evaluate canine urine specific gravity (USG) in veterinary clinical settings. We aimed determine if the magnitude of interobserver reliability when assessing USG via refractometry could impact judgment. was determined 38 dogs by 3 registered technicians (RVTs) using both an optical analog refractometer and a digital refractometer. Summary statistics were reported, assessed intraclass correlation coefficient (ICC) analysis through 2-way mixed-effects...
Aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) is a rare affecting dogs. Nutritional management pillar of optimal treatment. Currently, there are no specific published data to inform dietary nutrient composition selections for treating affected Thus, our goal was establish targets the ACHES by comparing profiles commercial and home-cooked diets fed dogs after diagnosis determine if different inclusions were associated with survival. This retrospective cohort study...
A benign duodenal stricture is a well-documented condition of humans that has not been characterized in dogs. In this case report, the clinical, radiographic, ultrasonographic, endoscopic, surgical, and histopathologic findings single Golden Retriever are reported. Definitive diagnosis was made possible with utilization esophagogastroduodenoscopy (EGD). Surgical correction stricture, paired dietary therapy utilized highly digestible diet, resolved clinical signs Several inciting causes were...