A5024050807- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Microbial infections and disease research
- Veterinary Equine Medical Research
- Virus-based gene therapy research
- Clinical Laboratory Practices and Quality Control
- Veterinary Medicine and Surgery
- Vector-Borne Animal Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Animal health and immunology
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Platelet Disorders and Treatments
- Birth, Development, and Health
- Veterinary Practice and Education Studies
- Sarcoma Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Pediatric Hepatobiliary Diseases and Treatments
- Actinomycetales infections and treatment
- Ocular Infections and Treatments
- Fungal Infections and Studies
- Sepsis Diagnosis and Treatment
- Blood groups and transfusion
- Metabolism and Genetic Disorders
- Venous Thromboembolism Diagnosis and Management
Tufts University
2004-2025
New England Disabled Sports
2018-2024
University College Dublin
2021
University of Minnesota
2011-2020
University of Veterinary Medicine
2004-2018
University of Minnesota System
2007-2018
University of Minnesota Medical Center
2013-2014
Sylvana Research
2013
National Cancer Institute
2013
Knowles (United States)
2010
Canine hemangiosarcomas have been ascribed to an endothelial origin based on histologic appearance; however, recent findings suggest that these tumors may arise instead from hematopoietic progenitor cells. To clarify this ontogenetic dilemma, we used genome-wide expression profiling of primary and identified three distinct tumor subtypes associated with angiogenesis (group 1), inflammation 2), adipogenesis 3). Based findings, hypothesized a common differentiate into the observed in our gene...
Abstract Background The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development this species. These could represent a constellation heritable characteristics that promote transformation events and/or facilitate the establishment microenvironment is conducive for survival malignant blood vessel-forming cells. hypothesis study was characteristic molecular features distinguish from non-malignant endothelial...
ABSTRACT Background Renal lipidosis is a well‐documented histologic finding in humans and small animals with renal metabolic disorders, but it not well described equids. Objective To describe the signalment, clinicopathologic indices, postmortem findings of equids diagnosis both hepatic (HL + RL) compare them to cases only (HL). Animals Equids necropsy or (state diagnostic lab) between 2008 2022. Methods Retrospective case–control study. Signalment, history, diagnosis, selected biochemical...
Abstract Objective —To determine whether dogs with renal failure have higher serum cardiac troponin I (cTnI) concentrations than healthy dogs. Design —Case-control study. Animals —31 and 51 Procedures —Serum of creatinine I, urine specific gravity, systolic arterial blood pressure were measured for all Dogs underwent a standardized physical examination, any dog evidence cardiovascular disease or other nonrenal was excluded from final analyses. considered to be in when the concentration ≥ 3.0...
There is inconclusive evidence about the role of sex as a risk factor for doxorubicin (DOX)-induced cardiotoxicity. Recent experimental studies have shown that adult female rats are protected against DOX-induced However, mechanisms this sexual dimorphism not fully elucidated. We previously demonstrated DOX alters expression several cytochrome P450 (CYP) enzymes in hearts male rats. Nevertheless, sex-dependent effect on CYP still known. Therefore, present study, we determined acute exposure...
Medical records from dogs having abdominal ultrasound (US) performed between March 2005 and October 2008 were reviewed for detection of focal liver lesions (FLL) with both cytologic histologic sampling. Samples classified as to either the presence or absence major categories pathologic processes, including malignant neoplasia, inflammation, hyperplasia/benign vacuolar change, extramedullary hematopoeisis, cholestasis, necrosis, no microscopic abnormalities. Evaluation selection bias was by...
Thyroxine (T4), free T4 (FT4), and thyrotropin (TSH) concentrations were measured in serum from 693 healthy representatives 7 dog breeds (Alaskan Malamute, Collie, English Setter, Golden Retriever, Keeshond, Samoyed, or Siberian Husky) to determine whether breed-specific reference intervals (RIs) are warranted. Veterinarians reviewed the health history, performed a physical examination, approved laboratory data for enrolled dogs. Many purebred dogs had FT4 that at, below, lower limits...
Background Mean platelet volume ( MPV ) and plateletcrit PCT are indices used in evaluating immune‐mediated thrombocytopenia IMT humans dogs with congenital macrothrombocytopenia. These may provide clinically valuable information acquired thrombocytopenia. Hypothesis/Objectives Dogs presumed primary will have increased , therefore mass increase faster than count PLT during recovery. Animals Forty‐nine automated < 30,000/μL because of hematocrit HCT ), distribution width determined from...
The diagnosis of pancreatic disease in small animal veterinary patients is complicated by nonspecific clinical signs and the limitations diagnostic testing. Pancreatic cytology a potential tool, but safety yield are not well characterized large patient cohorts. We hypothesized that fine-needle aspiration (FNA) dogs would frequently generate diagnostic-quality samples subsequent adverse medical events be uncommon. Ninety-two client-owned undergoing FNA for evaluation were identified...
Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and lesser degree cancer patients. Female rodents have shown be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms this sexual dimorphism are not fully elucidated. Therefore, current study, we investigated sex time-dependent changes pathological lesions as well apoptotic fibrotic markers response acute We also determined effect...
To compare results of the most common diagnostic tests for pulmonary blastomycosis in dogs, identify factors associated with outcome, and determine response to various antifungal treatment protocols.Retrospective case series.125 dogs blastomycosis.Medical records were reviewed, information was obtained regarding methods, routine laboratory testing, radiographic treatment.79 survived, 38 died, 8 euthanized. Transthoracic fine-needle aspiration transtracheal lavage methods. Results an agar gel...
Little is known about the potential consequences of pancreatic tissue sampling in dogs. The goal present study was to evaluate changes serum trypsin-like immunoreactivity and canine-specific lipase after fine-needle aspiration surgical biopsy 27 clinically healthy Presurgical, ultrasound-guided pancreas performed with dogs under sedation. Subsequently, all underwent intraoperative clamshell biopsy. After euthanasia, pancreata were sectioned for histopathologic evaluation. Serum enzyme levels...
Background The functional components of bone marrow (i.e., the hematopoietic and stromal populations) adjacent have traditionally been evaluated incompletely as distinct entities rather than integrated system. We perturbed this system in vivo using a medically relevant radiation model presence or absence ovarian function to understand tissue interaction. Methodology/Principal Findings Ovary-intact ovariectomized mice underwent either no single fractional 16 Gy caudal skeleton (I±R, OVX±R)....
Hemangiosarcoma (HSA) is a highly malignant tumour with aggressive biological behaviour. HSAs are more common in dogs than other domestic animals. The median survival time of HSA remains short, even chemotherapy and surgery. Therefore, there critical need to improve the adjuvant chemotherapeutic regimens clinical outcomes HSA. Resveratrol has been shown possess strong anti‐proliferative and/or pro‐apoptotic properties human cancer cell lines. Nevertheless, potential anticancer effects...
Background: The diagnostic value of cytology compared with histopathology varies by tissue, but there is little information regarding this comparison involving canine bone. Objectives: objective retrospective study was to compare primary pathologic processes for and bone lesions. We adopted a proposed standardized format reporting studies accuracy. Methods: A computer search medical records at the University Minnesota Veterinary Medical Center from September 2002 through October 2006...
To characterize platelet indices at time of diagnosis septic peritonitis in dogs and to assess the relationship between parameter data survival discharge treated surgically.Retrospective, observational, descriptive pilot study from 2009 2014.University teaching hospital.Forty-eight diagnosed with were included this study. Thirty-six had surgical source control. Blood samples 46 healthy control used for reference interval (RI) generation.None.Dogs significantly increased mean values volume...
The SHHF/Mcc-facp (spontaneous hypertension and heart failure) rat is advanced as a novel suitable non-primate model of pregnancy-associated fetal growth restriction because it simultaneously has spontaneous hypertension, small for gestational age (SGA) offsprings, altered placental gene expression. Pregnancy-associated major contributor to maternal morbidity mortality with the potential result in death need iatrogenic preterm delivery. It been reported develop spontaneously humans, but not...
Sexual dimorphism may occur during the development of hypertension and congestive heart failure (CHF). Male female spontaneous (SHHF) rats with established hypertension, but before CHF (age 5–8 mo) cardiac decompensation leading to 18–20 mo in male 22–24 rats), were studied. At mo, SHHF showed early activation renin-angiotensin system (RAS), as indicated by increased plasma renin activity (PRA) higher serum angiotensin-converting enzyme compared rats. The increase PRA was delayed males rats,...