A5036008316- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Polyomavirus and related diseases
- Myasthenia Gravis and Thymoma
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Statistical Methods in Clinical Trials
- Parkinson's Disease and Spinal Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neonatal Respiratory Health Research
- Global Cancer Incidence and Screening
- Skin Protection and Aging
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Urban Green Space and Health
- Mycobacterium research and diagnosis
- Acute Lymphoblastic Leukemia research
- Viral Infections and Immunology Research
- Indoor Air Quality and Microbial Exposure
- Dementia and Cognitive Impairment Research
University of Alabama at Birmingham
2016-2025
Institut de Myologie
2024
George Washington University
2018-2024
Harvard University
2024
Sorbonne Université
2024
Inserm
2024
Centre de Recherche en Myologie
2024
John Wiley & Sons (United States)
2018-2024
Hudson Institute
2018-2024
The University of Texas Southwestern Medical Center
2007-2024
Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment trials, treatment decision-making. Standardized published in 1996 based on a survey international MS experts provided purely phenotypes data consensus at that time, but imaging biological correlates were lacking. Increased understanding its pathology, coupled with general concern the original descriptors may not adequately reflect more...
The primary clinical outcome measure for evaluating multiple sclerosis in trials has been Kurtzke's expanded disability status scale (EDSS). New therapies appear to favourably impact the course of and render continued use placebo control groups more difficult. Consequently, future are likely compare active treatment which will most probably require increased sample sizes order detect therapeutic efficacy. Because responsive measures be needed arm comparison studies, National Multiple...
Background: The relationships among breast density, age, and use of hormone replacement therapy (HRT) in cancer detection have not been fully evaluated. Objective: To determine how HRT individually combination affect the accuracy screening mammography. Design: Prospective cohort study. Setting: 7 population-based mammography registries North Carolina; New Mexico; Hampshire; Vermont; Colorado; Seattle, Washington; San Francisco, California. Participants: 329 495 women 40 to 89 years age who...
<h3>Objective</h3> To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying validated algorithm to administrative health claims (AHC) datasets. <h3>Methods</h3> A was applied private, military, and public AHC datasets identify adult cases of MS between 2008 2010. In each dataset, we determined 3-year cumulative overall stratified age, sex, census region. We insurance-specific stratum-specific estimates 2010 US Census data pooled findings calculate...
Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence its benefit. We conducted multicenter, randomized trial comparing thymectomy plus prednisone with alone.We compared extended transsternal alternate-day alone. Patients 18 to 65 years age who had generalized nonthymomatous gravis disease duration less than 5 were included if they Myasthenia Gravis Foundation America clinical class II IV (on scale from I V, higher classes indicating more...
Oral bacterial levels of 46 mother-child pairs were monitored from infant birth up to five years age so that the acquisition mutans streptococci (MS) by children could be studied. The initial MS occurred in 38 at median 26 months during a discrete period we designated as "window infectivity". remained undetected eight (17%) until end study (median 56 mo). both and lactobacilli saliva mothers with without not significantly different. Comparisons between caries-active cohort colonized (nine...
With the large number of women having mammography-an estimated 28.4 million U.S. aged 40 years and older in 1998-the percentage cancers detected as ductal carcinoma situ (DCIS), which has an uncertain prognosis, increased. We pooled data from seven regional mammography registries to determine mammographically that are DCIS rate per 1000 mammograms.We analyzed on 653 833 mammograms 540 738 between 84 age who underwent screening at facilities participating National Cancer Institute's Breast...
Computer-aided detection identifies suspicious findings on mammograms to assist radiologists. Since the Food and Drug Administration approved technology in 1998, it has been disseminated into practice, but its effect accuracy of interpretation is unclear.
Vascular comorbidity adversely influences health outcomes in several chronic conditions. comorbidities are common multiple sclerosis (MS), but their impact on disease severity is unknown. may contribute to the poorly understood heterogeneity MS severity. Treatment of vascular represent an avenue for treating MS.
To determine the percentage of patients with residual deficits following multiple sclerosis (MS) exacerbations and magnitude those using a database pooled placebo from clinical trials.A assigned to group in several randomized trials was queried Expanded Disability Status Scale (EDSS) Scripps Neurologic Rating assessments prior to, at time of, after an acute exacerbation MS. The extent deficit present these points compared effect degree persistent disability.Forty-two percent had least 0.5...
<b><i>Background:</i></b> Interferon β-1a (IFNβ-1a, Avonex) is efficacious in relapsing forms of MS. Studies other IFNβ preparations secondary progressive MS (SPMS) yielded conflicting results. This study was undertaken to determine whether IFNβ-1a slowed disease progression SP-MS. <b><i>Methods:</i></b> A total 436 subjects with SPMS and Expanded Disability Status Scale (EDSS) score 3.5 6.5 were randomized receive (60 μg) or placebo by weekly intramuscular injection for 2 years. The primary...
The North American Research Committee on Multiple Sclerosis (NARCOMS) Registry is a database that contains information from over 35,000 patient volunteers symptom severity in 11 domains commonly affected multiple sclerosis (MS): mobility, hand function, vision, fatigue, cognition, bowel/bladder sensory, spasticity, pain, depression, and tremor/coordination. affords unique opportunity to study the frequency of domain-specific impairment contemporary, mostly treated MS cohort course disease....
To characterize the accrual of long-term disability in a cohort actively treated multiple sclerosis (MS) patients and to assess whether clinical magnetic resonance imaging (MRI) data used trials have prognostic value.This is prospective study 517 managed MS enrolled at single center.More than 91% were retained, with ascertained up 10 years after baseline visit. At this last assessment, neurologic as measured by Expanded Disability Status Scale (EDSS) was stable or improved compared 41%...
<b>Objective: </b> Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy. <b>Methods: thickness was measured 40 patients MS 15 controls. Brain parenchymal fraction (BPF) partial volumes were estimated from cranial MRI scans using SIENA-X. Multiple linear regression modeling the between OCT measures of <b>Results: Minimum subject age...
Background: The risk of elbow or shoulder injury for young baseball pitchers is unknown. Purpose/Hypothesis: purpose this study was to quantify the cumulative incidence throwing injuries in who were followed 10 years. Three hypotheses tested: Increased amount pitching, curveballs at a age, and concomitantly playing catcher increase pitcher’s injury. Study Design: Cohort study; Level evidence, 3. Methods: In sum, 481 youth (aged 9 14 years) enrolled 10-year follow-up study. Participants...
Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes RNFL relate to loss. also examined patterns thinning over time MS eyes without a prior history acute optic neuritis (ON).Patients underwent OCT measurement at baseline 6-month intervals during mean follow-up 18 months 3 centers. Low-contrast letter acuity (2.5%,...
The benefits and safety of the treatment mild chronic hypertension (blood pressure, <160/100 mm Hg) during pregnancy are uncertain. Data needed on whether a strategy targeting blood pressure less than 140/90 Hg reduces incidence adverse outcomes without compromising fetal growth.In this open-label, multicenter, randomized trial, we assigned pregnant women with singleton fetuses at gestational age 23 weeks to receive antihypertensive medications recommended for use in (active-treatment group)...
Summary Objective To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol ( CBD ; Epidiolex) and commonly used antiepileptic drugs AED s) through an open‐label safety study. Serum levels were monitored to s. Methods In 39 adults 42 children, dose was started at 5 mg/kg/day increased every 2 weeks by up a maximum 50 mg/kg/day. obtained baseline prior initiation most study visits. doses adjusted if it determined that clinical symptom or...