A5014370231- Multiple Sclerosis Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Reproductive System and Pregnancy
- Peripheral Neuropathies and Disorders
- Pregnancy and Medication Impact
- Retinal and Optic Conditions
- Polyomavirus and related diseases
- Ophthalmology and Visual Impairment Studies
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Pharmaceutical studies and practices
- Long-Term Effects of COVID-19
- Prion Diseases and Protein Misfolding
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- IgG4-Related and Inflammatory Diseases
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Mycobacterium research and diagnosis
- Family Support in Illness
- Mosquito-borne diseases and control
Hospital of the University of Pennsylvania
2002-2024
University of Pennsylvania
2009-2024
University of Southern California
2024
University of California, San Francisco
2023-2024
Northwestern University
2023-2024
Multiple Sclerosis Research Institute
2024
Multiple Sclerosis Center of Atlanta
2024
Duke University
2024
Brigham and Women's Hospital
2023-2024
Harvard University
2024
To report clinical and immunological investigations of contactin-associated protein-like 2 (Caspr2), an autoantigen encephalitis peripheral nerve hyperexcitability (PNH) previously attributed to voltage-gated potassium channels (VGKC).
SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune protection against COVID-19. However, little is known about mRNA vaccine-induced responses immunosuppressed patients. We investigated induction of antigen-specific antibody, B cell and T longitudinally patients with multiple sclerosis (MS) on anti-CD20 antibody monotherapy (n = 20) compared controls 10) after BNT162b2 or mRNA-1273 vaccination. Treatment monoclonal (aCD20) significantly reduced spike-specific...
Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes RNFL relate to loss. also examined patterns thinning over time MS eyes without a prior history acute optic neuritis (ON).Patients underwent OCT measurement at baseline 6-month intervals during mean follow-up 18 months 3 centers. Low-contrast letter acuity (2.5%,...
<h3>Background</h3> Inner (area adjacent to the fovea) and outer regions of macula differ with respect relative thicknesses ganglion cell layer (neurons) vs retinal nerve fiber (RNFL; axons). <h3>Objective</h3> To determine how inner macular volumes relate peripapillary RNFL thickness visual function in multiple sclerosis (MS) examine these patterns among eyes without a history acute optic neuritis (ON). <h3>Design</h3> Study using cross-sectional optical coherence tomography....
<b><i>Background:</i></b> Visual dysfunction is one of the most common causes disability in multiple sclerosis (MS). The Multiple Sclerosis Functional Composite (MSFC), a new clinical trial outcome measure, does not currently include test visual function. <b><i>Objective:</i></b> To examine contrast letter acuity as candidate function for MSFC. <b><i>Methods:</i></b> Binocular testing (Sloan charts) was performed subgroup participants from International Secondary Progressive Avonex...
<h3>Objective:</h3> To examine the relation between low contrast letter acuity, a new visual function test for multiple sclerosis (MS) trials, and vision targeted health related quality of life (HRQOL). <h3>Methods:</h3> Patients in this cross sectional study were part an ongoing investigation MS. tested binocularly using acuity Early Treatment Diabetic Retinopathy Study (ETDRS) (VA) charts. The 25 Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25), 10 Neuro-Ophthalmic...
A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This does not recur with further dosing, possibly reflecting deeper depletion CD20-expressing cells repeat infusions. We assessed cellular immune profiles and their association transient following initiation as a window into relapsing biology. Peripheral blood mononuclear from independent discovery validation cohorts MS initiating ocrelizumab were for phenotypic...
B cells can be enriched within meningeal immune-cell aggregates of multiple sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized as important contributors progressive disease. This demyelination is notable for a 'surface-in' gradient neuronal loss and microglial activation, potentially reflecting the effects soluble factors secreted into CSF. We previously demonstrated that MS B-cell products are toxic oligodendrocytes neurons. The potential...
<h3>Background</h3> Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx) are similar yet provide information on different aspects of retinal nerve fiber layer (RNFL) structure (thickness values to histology for OCT vs birefringence microtubules GDx). <h3>Objectives</h3> To compare the ability GDx distinguish eyes patients multiple sclerosis (MS) from disease-free controls thus identify RNFL abnormalities. We also sought examine capacity...
The objective of this study is to evaluate the safety and tolerability inosine in patients with relapsing-remitting multiple sclerosis (RRMS). secondary objectives are assess effects administration on serum urate (UA) levels, progression neurologic disability, cumulative number new, active lesions magnetic resonance imaging (MRI), changes levels for markers inflammation.Oral was used raise natural peroxynitrite scavenger UA 16 RRMS during a 1-year randomized, double-blind trial.The endpoints...
Immunosenescence (ISC) describes age-related changes in immune-system composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition involving effector regulatory T-cell imbalance, yet little known about ISC MS. We examined age-associated circulating T cells MS compared to normal controls (NC).
Patients with multiple sclerosis (MS) may seek fertility treatment (FT)-including in vitro fertilization (IVF). Variable relapse risk after IVF has been reported small historical cohorts, more recent studies suggesting no change annualized rate (ARR). The objective of this study was to evaluate ARR 12 months pre-FT and 3 post-FT a multicenter cohort identify factors associated an increased relapse.Patients clinically isolated syndrome (CIS) or MS aged 18-45 years at least 1 FT from January...
<h3>Objective</h3> To evaluate the safety and efficacy of cladribine tablets in patients still experiencing active relapsing MS despite interferon (IFN)-β treatment. <h3>Methods</h3> A 96-week phase II study, randomizing treated with IFN-β to 3.5 mg/kg/IFN-β or placebo/IFN-β. Patients were receive placebo/IFN-β a 2:1 ratio (n = 172) exploratory outcomes being assessed. <h3>Results</h3> Adverse events (AEs) serious AEs similar across treatment groups, except lymphopenia. Fifty 124 (40.3%)...
Abstract SARS-CoV-2 mRNA vaccination in healthy individuals generates effective immune protection against COVID-19. Little is known, however, about the vaccine-induced responses immunosuppressed patients. We investigated induction of antigen-specific antibody, B cell and T patients with multiple sclerosis on anti-CD20 (MS-aCD20) monotherapy following vaccination. Treatment aCD20 significantly reduced Spike RBD specific antibody memory most patients, an effect that was ameliorated longer...
<b>Objective: </b> To examine the relation between low-contrast letter acuity, an emerging visual outcome for multiple sclerosis (MS) clinical trials, and brain MRI abnormalities in MS cohort. <b>Methods: T2 lesion volume parenchymal fraction were determined whole within pathway regions of interest. Magnetization transfer ratio histograms examined. Vision testing was performed binocularly using acuity (2.5%, 1.25% contrast) high-contrast (VA). Linear regression, accounting age disease...
Abstract Objective Postpartum, patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have increased risk for disease activity. Anti‐CD20 IgG1 monoclonal antibodies (mAb) are increasingly used as disease‐modifying therapies (DMTs). Patients may wish to both breastfeed resume DMT postpartum. This study aimed determine the transfer of anti‐CD20 mAbs, ocrelizumab, rituximab (OCR/RTX), into mature breastmilk describe maternal infant outcomes. Methods Fifty‐seven...
A 36-year-old woman presented with severe dysarthria, axial and appendicular tremor, ataxia.Symptoms began the tremor 2 years prior to presentation.Neurologic examination revealed presence of Kayser-Fleischer rings (figure, A), dysarthria dysphonia, akathisia, truncal left hemiparesis, dystonia.Serum ceruloplasmin was markedly decreased at 10 mg/dL (normal 18 55 mg/dL).An MRI diffuse white matter abnormalities bilateral symmetric involvement midbrain, pons, inferior cerebellum, thalami,...
PBMC cocultured with HIV-infected monocytes for 12 to 48 h released high levels of IFN activity. titers were directly dependent upon time after virus infection and level HIV replication in infected cells. induction was evident myeloid lymphoblastoid cell lines at least three different strains. In line pairs which occurs both productive restricted forms, occurred only infection. activity acid stable completely neutralized by antibodies against IFN-alpha. Induction required cell-cell contact...