A5038709305- Dementia and Cognitive Impairment Research
- Medical Image Segmentation Techniques
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
- Mosquito-borne diseases and control
- Cerebral Palsy and Movement Disorders
- Multiple Sclerosis Research Studies
- Muscle activation and electromyography studies
- Intensive Care Unit Cognitive Disorders
- Neurobiology of Language and Bilingualism
- Viral Infections and Vectors
- Ear Surgery and Otitis Media
- Glioma Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Biological Research and Disease Studies
- Medical Imaging and Analysis
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury Research
- COVID-19 epidemiological studies
- Diverse Scientific Research Studies
D’Or Institute for Research and Education
2007-2025
Universidade Federal de Minas Gerais
2024
West Kazakhstan Marat Ospanov State Medical University
2024
Manipal Academy of Higher Education
2016
Universidade Federal do Rio de Janeiro
2013
Universidade Federal de São Carlos
2011
Colciencias
2009
Universidade Federal Fluminense
2007
Johns Hopkins University
2007
University of Pennsylvania
2007
Abstract Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing clinical use methylation profiling next-generation sequencing has led to identification molecularly distinct subtypes. One proposed tumor type, CNS with BRD4::LEUTX fusion, been described. As only few fusions have described, we herein characterize cohort 9 such cases (4 new, 5 previously published) further describe their clinicopathologic molecular features. We...
<b>Objective: </b> To examine the relation between low-contrast letter acuity, an emerging visual outcome for multiple sclerosis (MS) clinical trials, and brain MRI abnormalities in MS cohort. <b>Methods: T2 lesion volume parenchymal fraction were determined whole within pathway regions of interest. Magnetization transfer ratio histograms examined. Vision testing was performed binocularly using acuity (2.5%, 1.25% contrast) high-contrast (VA). Linear regression, accounting age disease...
COVID-19 induces acute and persistent neurological symptoms in mild severe cases. Proposed concomitant mechanisms include direct viral infection strain, coagulopathy, hypoxia, neuroinflammation. However, underlying molecular alterations associated with multiple outcomes both cases are majorly unexplored. To illuminate possible leading to disease, we retrospectively investigated detail a cohort of 35 hospitalized patients presenting subject clinically indicated cerebrospinal fluid (CSF)...
Narrative discourse (ND) refers to one's ability verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur subjects with Amnestic Mild Cognitive Impairment (aMCI) Alzheimer's Disease (AD), but correlates across this function, neuroimaging cerebrospinal fluid (CSF) AD biomarkers remain understudied.
The addition of functional electrical stimulation (FES) to treadmill gait training with partial body weight support (BWS) has been proposed as a strategy facilitate in people hemiparesis. However, there is lack studies that evaluate the effectiveness FES on ground level BWS, which most common locomotion surface.To investigate additional effects commum peroneal nerve combined and BWS level, spatial-temporal parameters, segmental angles, motor function.Twelve chronic hemiparesis participated...
Background Episodic memory impairments have been described as initial clinical findings in the Alzheimer's Disease (AD) spectrum, which could be associated with presence of early hippocampal dysfunction. However, correlates between performances neuropsychological tests and volumes AD were inconclusive literature. Divergent methods to assess episodic depicted a major source heterogeneity across studies. Methods We examined among three different delayed-recall tasks (Rey-Auditory...
<i>Background/Aims:</i> The diagnosis of mild or questionable Alzheimer’s disease (AD) depends on clinical criteria that often leave a margin for doubt. We aim to verify the diagnostic accuracy amnestic cognitive impairment (aMCI) and AD with proton spectroscopy (<sup>1</sup>H-MRS) combined brief cognitive-functional scales. <i>Methods:</i> relationship between <sup>1</sup>H-MRS posterior cingulate cortex performance in Mini Mental State...
Abstract Objectives Anosognosia is the inability to recognize one's own symptoms. Although dementia with Lewy bodies (DLB) second most common degenerative dementia, there little evidence of memory deficit awareness in this condition. The objectives research were compare anosognosia between individuals DLB and due Alzheimer's disease (AD) evaluate whether medial temporal atrophy, a marker AD pathology, could help explain different rates AD. Methods/Design This cross‐sectional study that took...
The non-invasive in vivo nature of magnetic resonance imaging (MRI) makes it the modality choice many neuroanatomical studies. This paper discusses automatic brain structure segmentation based on previous knowledge statistical models. method is validated by an experiment involving images acquired from 20 healthy adult individuals (10 men and 10 women). results provide normative data midsagittal surface area corpus callosum a 46-55 years old range group, splitting gender. Our were also...
The availability of modern computational techniques and advanced medical imaging protocols has increased the development computer-aided diagnosis systems. This paper presents a fully automated brain structures segmentation algorithm for magnetic resonance (MR) images. Automated mechanisms reduce excessive time consumed on manual standardise volumetric acquisition method. proposed image method is based voxel-wise morphometry method, named voxel-based (VBM). structure interest this...
Experimental studies in nonhuman primates have questioned the selectivity of pyramidal tract damage giving rise to classical syndrome humans, characterized by permanent spastic hemiplegia (PSH). According this view, concomitant injury extrapyramidal pathways is necessary for development both and spasticity. In study we used conventional magnetic resonance imaging diffusion tensor tractography characterize anatomical correlates PSH a patient with rare discrete unilateral lesion medullary...
Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders benefits from higher field scanners as signal intensity spectral resolution are proportional strength.To investigate effects on measurement metabolites typical routine clinical setting.Single voxel spectra were acquired posterior cingulate cortex 26 healthy subjects. Each subject was scanned consecutively at 1.5T 3.0T randomly distributed...
<title>Abstract</title> COVID-19 induces acute and persistent neurological symptoms in mild severe cases. Proposed concomitant mechanisms include direct viral infection strain, coagulopathy, hypoxia, neuroinflammation. However, underlying molecular alterations associated with multiple outcomes both cases are majorly unexplored. To illuminate possible leading to disease, we retrospectively investigated detail a cohort of 35 hospitalized patients presenting subject clinically indicated...
Background: The Cognitive Domains and Functional Assessment Questionnaire (CDFAQ) assess cognitive functional decline based on the DSM-5 criteria for Neurocognitive Disorders. Its accuracy has been assessed was translated validated into English. informant version (CDFAQ-IV) is a 30-item questionnaire that assesses six domains with 5 items each: Complex Attention (CA), Executive Functions (EF), Learning Memory (LM), Language (L), Perceptual-Motor (PM) Social Cognition. development of CDFAQ-IV...
Lobotomy was a widespread neurosurgical procedure in the first half of 20th century. It used as treatment for various mental disorders. The development psychosurgeries Brazil, their indications, effects, consequences, advancements, well social context population subjected to it are revised herein. Also, an illustrative case report elderly Brazilian bipolar disorder patient who underwent this 1940's is described paper. article promotes critical debate around ethical and implications practice,...
Abstract Background Short screening tools designed to detect cognitive impairment are important for clinical and research. The Clinical Dementia Rating (CDR) is the main used categorization system, which classifies from no dementia, questionable dementia/mild (MCI) three severities of dementia. Objective To conduct an accuracy analysis different short tests predict CDR scores on a cohort Memory Clinic. Methods This cross‐sectional study, using data Cog‐Aging study in 2023. Participants go...