A5042591162- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Advanced NMR Techniques and Applications
- Muscle metabolism and nutrition
- Biochemical effects in animals
- Electroconvulsive Therapy Studies
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Mitochondrial Function and Pathology
- Obsessive-Compulsive Spectrum Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Free Radicals and Antioxidants
- Epilepsy research and treatment
- Diet and metabolism studies
- Electron Spin Resonance Studies
- Alzheimer's disease research and treatments
- Electrolyte and hormonal disorders
- Glioma Diagnosis and Treatment
- Ion channel regulation and function
- RNA regulation and disease
- Multiple Sclerosis Research Studies
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015-2025
Universidade de São Paulo
2015-2024
Instituto do Coração
2023
Siemens (Brazil)
2022
Resonance Research (United States)
2016
Max Planck Institute for Biological Cybernetics
2016
Institute for Biomedical Engineering
2016
ETH Zurich
2016
National Institute of Mental Health
2015
Indiana University School of Medicine
2014
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
The aim of this study was to investigate the effects beta-alanine supplementation on exercise capacity and muscle carnosine content in elderly subjects. Eighteen healthy subjects (60-80 years, 10 female 4 male) were randomly assigned receive either (BA, n=12) or placebo (PL, n=6) for 12 weeks. BA group received 3.2 g per day (2×800 mg sustained-release Carnosyn™ tablets, given 2 times day). PL 2× mg) a matched placebo. At baseline (PRE) after weeks (POST-12) supplementation, assessments made...
A method named DECOMPOSE-QSM is developed to decompose bulk susceptibility measured with QSM into sub-voxel paramagnetic and diamagnetic components based on a three-pool complex signal model.Multi-echo gradient echo modeled as summation of three weighted exponentials corresponding types sources: reference susceptibility, relative the reference. Paramagnetic component (PCS) (DCS) maps are constructed represent compartments by solving for linear nonlinear parameters in model.Numerical forward...
Creatine supplementation improves glucose tolerance in healthy subjects.The aim was to investigate whether creatine has a beneficial effect on glycemic control of type 2 diabetic patients undergoing exercise training.A 12-wk randomized, double-blind, placebo-controlled trial performed. The were allocated receive either (CR) (5 g·d) or placebo (PL) and enrolled an training program. primary outcome glycosylated hemoglobin (HbA1c). Secondary outcomes included the area under curve glucose,...
Abstract Objective Mitochondrial dysfunction and energy metabolism impairment are key components in the pathophysiology of bipolar disorder (BD) may involve a shift from aerobic to anaerobic metabolism. Measurement brain lactate vivo using proton magnetic resonance spectroscopy ( 1 H-MRS) represents an important tool evaluate mitochondrial metabolic during mood episodes, as well monitor treatment response. To date, very few studies have quantified BD. In addition, no study has longitudinally...
Oxidative stress and mitochondrial dysfunction are 2 closely integrated processes implicated in the physiopathology of bipolar disorder. Advanced proton magnetic resonance spectroscopy techniques enable measurement levels lactate, main marker dysfunction, glutathione, predominant brain antioxidant. The objective this study was to measure lactate glutathione disorder healthy controls. Eighty-eight individuals (50 38 controls) underwent 3T dorsal anterior cingulate cortex (2x2x4.5cm3) using a...
To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients.A 16-week, randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Fibromyalgia patients were randomly assigned to receive either monohydrate or placebo a double-blind manner. The evaluated at baseline after 16 weeks. Muscle function, aerobic conditioning, cognitive quality sleep, life, kidney adverse events assessed. phosphorylcreatine content measured through (31) P...
Objectives Two independent studies were conducted to examine the effects of 28 d beta-alanine supplementation at 6.4 g d-1 on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) cognitive function before after exercise trained cyclists 2). Methods In Study 1, seven healthy (3 women 4 men) age- sex-matched undertook a 1H-MRS exam baseline supplementation. study 2, nineteen male completed four 20-Km cycling time trials (two pre two post supplementation), with battery...
Creatine/phosphorylcreatine (PCr) responses to creatine supplementation may be modulated by age, diet, and tissue, but studies assessing this possibility are lacking. Therefore we aimed determine whether PCr vary as a function of tissue. Fifteen children, 17 omnivorous 14 vegetarian adults, 18 elderly individuals ("elderly") participated in study. Participants were given placebo subsequently (0.3 g·kg-1·day-1) for 7 days single-blind fashion. was measured through phosphorus magnetic...
Background:The hippocampus has been highly implicated in the pathophysiology of bipolar disorder (BD). Nevertheless, no study longitudinally evaluated hippocampal metabolite levels depression under treatment with lithium.
Abstract Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) modulation brain morphology. medial prefrontal cortex (mPFC) widely mood regulation BD, but role this mPFC morphology aging yet to be elucidated. One hundred seventeen euthymic BD type I subjects were genotyped underwent 3 T three-dimensional...
Brain abnormalities are a concern in COVID-19, so we used minimally invasive autopsy (MIA) to investigate it, consisting of brain 7T MR and CT images tissue sampling via transethmoidal route with at least three fragments: the first one for reverse transcription polymerase chain reaction (RT-PCR) analysis remaining fixed stained hematoxylin eosin. Two mouse monoclonal anti-coronavirus (SARS-CoV-2) antibodies were employed immunohistochemical (IHC) reactions.
Abstract Previous diffusion MRI studies have reported mixed findings on white matter microstructure alterations in obsessive-compulsive disorder (OCD), likely due to variation demographic and clinical characteristics, scanning methods, underpowered samples. The OCD global study was created across five international sites overcome these challenges by harmonizing data collection identify consistent brain signatures of that are reproducible generalizable. Single-shell measures (e.g., fractional...