A5073323104- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Immune Cell Function and Interaction
- Amyotrophic Lateral Sclerosis Research
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Skin and Cellular Biology Research
- Chronic Lymphocytic Leukemia Research
- Systemic Sclerosis and Related Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Glioma Diagnosis and Treatment
- Prion Diseases and Protein Misfolding
- Galectins and Cancer Biology
- Chronic Myeloid Leukemia Treatments
- Sphingolipid Metabolism and Signaling
- RNA regulation and disease
- Chromosomal and Genetic Variations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gene expression and cancer classification
- Cell Image Analysis Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Health First
2022
National Multiple Sclerosis Society
2020
Sir Charles Gairdner Hospital
2020
University College London
2020
Roche (Switzerland)
2020
Northwestern University
2011-2016
The University of Texas Southwestern Medical Center
2005-2013
The University of Texas at Austin
2011
Neurology, Inc
2009
The University of Texas Medical Branch at Galveston
1981
Targeted immune tolerance is a coveted therapy for the treatment of variety autoimmune diseases, as current options often involve nonspecific immunosuppression. Intravenous (iv) infusion apoptotic syngeneic splenocytes linked with peptide or protein autoantigens using ethylene carbodiimide (ECDI) has been demonstrated to be an effective method inducing peripheral, antigen-specific disease. Here, we show ability biodegradable poly(lactic-co-glycolic acid) (PLG) nanoparticles function safe,...
BackgroundNeurofilament light chain (NfL), a neuronal cytoskeletal protein that is released upon neuroaxonal injury, associated with multiple sclerosis (MS) relapsing activity and has demonstrated some prognostic ability for future relapse-related disease progression, yet its value in assessing non-relapsing progression remains unclear.MethodsWe examined baseline longitudinal blood NfL levels 1421 persons MS (RMS) 596 primary progressive (PPMS) from the pivotal ocrelizumab trials....
Importance Biomarkers distinguishing nonrelapsing progressive disease biology from relapsing in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an accessible that most closely reflects central nervous system biology. Objective To identify CSF biological measures associated with MS pathobiology. Design, Setting, and Participants This cohort study assessed data 2 prospective cohorts: a test provided serial CSF, clinical, imaging assessments multicenter of patients (RMS) or...
Abstract Ag-specific tolerance is a highly desired therapy for immune-mediated diseases. Intravenous infusion of protein/peptide Ags linked to syngeneic splenic leukocytes with ethylene carbodiimide (Ag-coupled splenocytes [Ag-SP]) has been demonstrated be efficient method inducing peripheral, T cell treatment autoimmune disease. However, little understood about the mechanisms underlying this therapy. In study, we show that apoptotic Ag-SP accumulate in marginal zone, where their uptake by...
A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This does not recur with further dosing, possibly reflecting deeper depletion CD20-expressing cells repeat infusions. We assessed cellular immune profiles and their association transient following initiation as a window into relapsing biology. Peripheral blood mononuclear from independent discovery validation cohorts MS initiating ocrelizumab were for phenotypic...
Angiopoietin-like protein 3 and 4 (Angptl3 Angptl4) are two members of the angiopoietin-like family proteins. These closely related proteins have been reported to similarly affect lipid metabolism through their capacity inhibit lipoprotein lipase. We undertook a series studies compare structure, function, regulation Angptl3 Angptl4. Previously, we that Angptl4 exists as variable-sized oligomers contain intermolecular disulfide bonds. now evidence although there no bonds evident in Angptl3,...
Abstract Recent evidence suggests that B‐ and T‐cell interactions may be paramount in relapsing‐remitting MS (RRMS) disease pathogenesis. We hypothesized memory B‐cell pools from RRMS patients specifically harbor a subset of potent neuro‐APC support neuro‐Ag reactive proliferation cytokine secretion. To test this hypothesis, we compared CD80 HLA‐DR expression, IL‐10 lymphotoxin‐α secretion, binding capacity, presentation by B cells to naïve healthy donors (HD). identified some elicited CD4 +...
Abstract Objective To develop an age‐adjustment model for neurofilament light chain (NfL), emerging injury marker in patients with a range of neurologic conditions including multiple sclerosis (MS). Methods Serum and plasma samples were collected from healthy donor (HD) cohort 118 individuals aged 24 to 66 years, 90 relapsing MS (RMS) 22 progressive (PMS). assessed NfL using the SIMOA assay (Quanterix Advantage Kit™). A log‐linear was used evaluate relationship between age calculate...
Recent clinical trials have established B cell depletion by the anti-CD20 chimeric antibody Rituximab as a beneficial therapy for patients with relapsing-remitting multiple sclerosis (MS). The impact of on T responses remains largely unexplored. In experimental autoimmune encephalomyelitis (EAE) model MS in mice that express human CD20, administration rapidly depleted peripheral cells and strongly reduced EAE severity. was also associated diminished Delayed Type Hypersensitivity (DTH)...
Multiple sclerosis is an inflammatory and degenerative disease characterized by different clinical courses including relapsing multiple (RMS) primary-progressive-multiple (PPMS). A hallmark of patients with sclerosis(pwMS) includes a putative autoimmune response, which results in demyelination neuroaxonal damage the central nervous system. Sphingolipids cerebrospinal fluid (CSF) have been proposed as potential biomarkers reflective activity pwMS. Hence, sensitive methods to accurately...
Abstract Leukocyte trafficking into the CNS is a prominent feature driving immunopathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Blocking recruitment inflammatory leukocytes represents an exploitable therapeutic target; however, adhesion molecules that specifically regulate step leukocyte diapedesis remain poorly understood. We report CD99 critical for lymphocyte transmigration without affecting in human blood–brain barrier model. blockade...
Abstract Background Bruton’s tyrosine kinase (BTK) is an intracellular signaling enzyme that regulates B-lymphocyte and myeloid cell functions. Due to its involvement in both innate adaptive immune compartments, BTK inhibitors have emerged as a therapeutic option autoimmune disorders such multiple sclerosis (MS). Brain-penetrant, small-molecule may also address compartmentalized neuroinflammation, which proposed underlie MS disease progression. expressed by microglia, are the resident cells...