A5050939922- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Radical Photochemical Reactions
- Photopolymerization techniques and applications
- Photochromic and Fluorescence Chemistry
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Virus-based gene therapy research
- Ruminant Nutrition and Digestive Physiology
- Crystallization and Solubility Studies
- Advanced Photocatalysis Techniques
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Lipid Membrane Structure and Behavior
- Computational Drug Discovery Methods
- Diabetes and associated disorders
- Food Allergy and Anaphylaxis Research
- CAR-T cell therapy research
- Neonatal Respiratory Health Research
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2020-2025
University of Maryland, Baltimore
2019-2025
Advanced Dermatology
2024
Advanced Dermatology & Cosmetic Surgery
2024
University of Maryland, College Park
2024
U-M Rogel Cancer Center
2022-2023
University of Colorado Boulder
2016-2020
Colorado State University
2018-2020
University of Michigan
2016-2020
Astellas Pharma (United States)
2017-2020
N-Aryl phenoxazines have been synthesized and introduced as strongly reducing metal-free photoredox catalysts in organocatalyzed atom transfer radical polymerization for the synthesis of well-defined polymers. Experiments confirmed quantum chemical predictions that, like their dihydrophenazine analogs, photoexcited states phenoxazine are achieve superior performance when they possess charge character. We compare to previously reported dihydrophenazines phenothiazines gain insight into these...
We demonstrate by molecular dynamics simulations that graphene sheets could be hosted in the hydrophobic interior of biological membranes formed amphiphilic phospholipid molecules. Our simulation shows these hybrid graphene−membrane superstructures might prepared forming hydrated micelles individual flakes covered phospholipids, which can then fused with membrane. Since layers membrane electrically isolate embedded from external solution, composite system used development biosensors and...
Through the study of structure–property relationships using a combination experimental and computational analyses, number phenoxazine derivatives have been developed as visible light absorbing, organic photoredox catalysts (PCs) with excited state reduction potentials rivaling those highly reducing transition metal PCs. Time-dependent density functional theory (TD-DFT) modeling photoexcitation N-aryl core modified phenoxazines guided design PCs absorption profiles in regime. In accordance...
Abstract Photoredox catalysis is a versatile approach for the construction of challenging covalent bonds under mild reaction conditions, commonly using photoredox catalysts (PCs) derived from precious metals. As such, there need to develop organic analogues as sustainable replacements. Although several PCs have been introduced, remains lack strongly reducing, visible‐light PCs. Herein, we establish critical photophysical and electrochemical characteristics both dihydrophenazine phenoxazine...
The incorporation of structural color into 3D printed parts is reported, presenting an alternative to the need for pigments or dyes colored produced through additive manufacturing. Thermoplastic build materials composed dendritic block copolymers were designed, synthesized, and used additively manufacture plastic exhibiting color. reflection properties photonic crystals arise from periodic nanostructure formed copolymer self-assembly during polymer processing. wavelength reflected light...
The Birch reduction is a powerful synthetic methodology that uses solvated electrons to convert inert arenes 1,4-cyclohexadienes-valuable intermediates for building molecular complexity. reductions traditionally employ alkali metals dissolved in ammonia produce electron the of unactivated such as benzene (
Organocatalyzed atom transfer radical polymerization (O-ATRP) has emerged as a metal-free variant of historically transition-metal reliant polymerization. Strongly reducing organic photoredox catalysts have proven capable mediating O-ATRP. To date, operation photoinduced O-ATRP been demonstrated in batch reactions. However, continuous flow approaches can provide efficient irradiation reaction conditions and thus enable increased performance. Herein, the adaptation to approach performed with...
A key feature of prominent transition-metal-containing photoredox catalysts (PCs) is high quantum yield access to long-lived excited states characterized by a change in spin multiplicity. For organic PCs, challenges emerge for promoting excited-state intersystem crossing (ISC), particularly when potent reductants are desired. Herein, we report design exploiting orthogonal π-systems and an intermediate-energy charge-transfer state maximize ISC yields (ΦISC) highly reducing (E0* = −1.7 V vs...
An enormous effort has been put into designing nanoparticles (NPs) with controlled biodistributions, prolonged plasma circulation times, and/or enhanced tissue targeting. However, little is known about how to design NPs precise distributions in the target tissues. In particular, understanding NP tumor penetration and accumulation characteristics crucial maximizing therapeutic potential of drug molecules carried by NPs. this study, we employed poly(amidoamine) (PAMAM) dendrimers, given their...
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-specific immunological tolerance in multiple immune models and are at various stages of commercial development. Association Ag with NPs is typically achieved through surface coupling or encapsulation methods. However, these methods limitations that include high polydispersity, uncontrollable loading release, possible immunogenicity. Here, using antigenic peptides conjugated poly(lactide-co-glycolide), we...
Research Article| April 01 1943 The utilization of urea in the bovine rumen. 3. synthesis and breakdown protein rumen ingesta R. M. Pearson; Pearson 1The Hannah Dairy Institute, Kirkhill, Ayr Search for other works by this author on: This Site PubMed Google Scholar J. A. B. Smith Biochem J (1943) 37 (1): 153–164. https://doi.org/10.1042/bj0370153 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Cite Get Permissions...
Research Article| April 01 1943 The utilization of urea in the bovine rumen. 2. conversion to ammonia R. M. Pearson; Pearson 1The Hannah Dairy Institute, Kirkhill, Ayr Search for other works by this author on: This Site PubMed Google Scholar J. A. B. Smith Author and article information Publisher: Portland Press Ltd © CAMBRIDGE UNIVERSITY PRESS1943 Biochem J (1943) 37 (1): 148–153. https://doi.org/10.1042/bj0370148 Views Icon Article contents Figures & tables Video Audio Supplementary Data...
Significance Allergic diseases are characterized by inappropriate inflammatory responses to benign environmental antigens (Ags). Primary clinical approaches allergic disease consist of symptom control or administration soluble Ag skew the immune response alternate phenotypes induce tolerance. However, such carry a significant risk adverse events and require long treatment course achieve efficacy. In this paper, we describe use i.v.-administered nanoparticles as carriers whole-protein...
To access the key Ile-Hpa pseudodipeptide motif in hibispeptins, a series of bidentate carboxamide-based auxiliary groups have been explored to facilitate palladium-catalyzed arylation unactivated γ-C(sp(3))-H bonds Ile precursor with aryl iodides. A new pyridylmethylamine-based group PR is introduced, which permits use more sterically hindered ortho-substituted iodide substrates and can be removed under mild conditions. Pd-catalyzed PR-directed enabled first total synthesis hibispeptin A.
Organic photoredox catalysts have been shown to operate organocatalyzed atom transfer radical polymerizations (O-ATRP) using visible light as the driving force. In this work, effect of intensity from white LEDs was evaluated an influential factor in control over polymerization and production well-defined polymers. We posit irradiation conditions concentrations various catalyst states necessary mediate a controlled polymerization. Systematic dimming allowed for consideration role on...
Current strategies for treating autoimmunity involve the administration of broad-acting immunosuppressive agents that impair healthy immunity. Intravenous (i.v.) poly(lactide-co-glycolide) nanoparticles (NPs) containing disease-relevant antigens (Ag-NPs) have demonstrated antigen (Ag)-specific immune tolerance in models autoimmunity. However, subcutaneous (s.c.) delivery Ag-NPs has not been effective. This investigation tested hypothesis codelivery immunomodulatory cytokine, transforming...