A5014372247- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Family Support in Illness
- Immunotherapy and Immune Responses
- Glycogen Storage Diseases and Myoclonus
- Rheumatoid Arthritis Research and Therapies
- Patient-Provider Communication in Healthcare
- Microfluidic and Bio-sensing Technologies
- Radiopharmaceutical Chemistry and Applications
- Neurogenetic and Muscular Disorders Research
- Infectious Encephalopathies and Encephalitis
- Autoimmune Neurological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Neurological and metabolic disorders
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Infections and Vaccines
- Microbial Inactivation Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- CNS Lymphoma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
University of Massachusetts Chan Medical School
2016-2025
University of Vermont
2017-2025
Brigham and Women's Hospital
2025
Harvard University
2025
Massachusetts General Hospital
2025
UMass Memorial Medical Center
2013-2023
UMass Memorial Health Care
2011-2023
Memorial Medical Center
2013-2021
Neurology, Inc
2020
University of Nebraska–Lincoln
2017
Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs' cycle intermediates that alter transcription of immune response genes. We extended these observations by defining fumarate as an inhibitor pyroptotic cell death. found dimethyl (DMF) delivered cells or endogenous reacts with gasdermin D (GSDMD) at critical cysteine residues form S-(2-succinyl)-cysteine. GSDMD succination prevents its interaction caspases, limiting processing, oligomerization, and...
In multiple sclerosis (MS), using simultaneous magnetic resonance-positron emission tomography (MR-PET) imaging with 11 C-PBR28, we quantified expression of the 18kDa translocator protein (TSPO), a marker activated microglia/macrophages, in cortex, cortical lesions, deep gray matter (GM), white (WM) and normal-appearing WM (NAWM) to investigate vivo pathological clinical relevance neuroinflammation.Fifteen secondary-progressive MS (SPMS) patients, 12 relapsing-remitting (RRMS) 14 matched...
Importance Biomarkers distinguishing nonrelapsing progressive disease biology from relapsing in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an accessible that most closely reflects central nervous system biology. Objective To identify CSF biological measures associated with MS pathobiology. Design, Setting, and Participants This cohort study assessed data 2 prospective cohorts: a test provided serial CSF, clinical, imaging assessments multicenter of patients (RMS) or...
A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This does not recur with further dosing, possibly reflecting deeper depletion CD20-expressing cells repeat infusions. We assessed cellular immune profiles and their association transient following initiation as a window into relapsing biology. Peripheral blood mononuclear from independent discovery validation cohorts MS initiating ocrelizumab were for phenotypic...
Tolebrutinib is an oral, brain-penetrant, and bioactive Bruton's tyrosine kinase inhibitor that modulates peripheral inflammation persistent immune activation within the central nervous system, including disease-associated microglia B cells. More data are needed on its efficacy safety in treating relapsing multiple sclerosis. In two phase 3, double-blind, double-dummy, event-driven trials (GEMINI 1 GEMINI 2), participants with sclerosis were randomly assigned a 1:1 ratio to receive...
Compartmentalized meningeal inflammation is thought to represent one of the key players in pathogenesis cortical demyelination multiple sclerosis. PET targeting 18 kDa mitochondrial translocator protein (TSPO) a molecular-specific approach quantifying immune cell-mediated density cortico-meningeal tissue compartment vivo. This study aimed characterize and TSPO expression heterogeneous cohort sclerosis cases using vivo simultaneous MR-PET with 11C-PBR28, second-generation radioligand, ex...
Abstract Background In the phase 2 CAMMS223 trial (NCT00050778), alemtuzumab significantly improved clinical and MRI outcomes versus subcutaneous interferon beta-1a over 3 years in treatment-naive patients with relapsing–remitting MS. Here, we assess efficacy safety of 12 who enrolled CAMMS03409 extension (NCT00930553), available follow-up through subsequent TOPAZ (NCT02255656). Methods CAMMS223, received courses (12 mg/day; baseline: 5 days; months later: days); 22% a third course....
Paramagnetic rims have been observed as a feature of some multiple sclerosis (MS) lesions on susceptibility-sensitive magnetic resonance imaging (MRI) and indicate compartmentalized inflammation.
Objective To determine the prevalence of JC virus (JCV) reactivation and JCV‐specific cellular immune response during prolonged natalizumab treatment for multiple sclerosis (MS). Methods We enrolled 43 JCV‐seropositive MS patients, including 32 on monotherapy >18 months, 6 interferon β‐1a >36 5 untreated controls. performed quantitative real‐time polymerase chain reaction in cerebrospinal fluid (CSF), blood, urine JCV DNA, we determined T‐cell responses using enzyme‐linked...
The neuromuscular presentation of glycogen branching enzyme deficiency includes a severe infantile form and late-onset variant known as adult polyglucosan body disease. Herein, we describe 2 patients with acute onset fluctuating neurological signs brain magnetic resonance imaging lesions simulating multiple sclerosis. A better definition this new clinical entity is needed to facilitate diagnosis.To the progression intermediate discuss genotype-phenotype correlations.Clinical, biochemical,...
Multiple sclerosis (MS) affects more than 1 million people in the United States, including reproductive-age women. There has been a paucity of prospective, pregnancy registries based on MS disease rather medication exposures. A prospective registry (PREG-MS) was established 2017 as single-cohort, real-world New England States with goals to evaluate (1) course and disease-modifying therapies (DMT) use during conception attempts peripartum period, (2) outcomes women (WwMS), (3) longer-term...
The authors' findings suggest that major depressive disorder (MDD) may occur as a prodrome to and delay diagnosis of multiple sclerosis (MS). Lifetime prevalence MDD was 59%; 14% subjects reported MS, 10% resulting in MS diagnosis.
Background. Patients facing a high-stakes clinical decision are often confronted with an overwhelming array of options. High-quality decisions about treatment should reflect patients’ preferences as well their characteristics. Preference-assessment instruments typically focus on pre-selected outcomes and attributes chosen by the investigator. Objective. We sought to develop patient-centered approach elicit compare goals patients multiple sclerosis (MS) healthcare providers (HCPs). Methods....
The authors' findings suggest that major depressive disorder (MDD) may occur as a prodrome to and delay diagnosis of multiple sclerosis (MS). Lifetime prevalence MDD was 59%; 14% subjects reported MS, 10% resulting in MS diagnosis.
The aim of these guidelines is to make the process reporting body fluid biomarker studies in neurologic disorders more uniform and transparent, line with existing standards for research other biomedical areas. Although biomarkers have been around decades, there are concerns over high attrition rate promising candidate at later phases development.BioMS-eu consortium, a collaborative network working toward improving quality disorders, discussed merits standardizing research. A checklist items...
An 18-protein multiple sclerosis (MS) disease activity (DA) test was validated based on associations between algorithm scores and clinical/radiographic assessments (N = 614 serum samples; Train [n 426; development] Test 188; evaluation] subsets). The multi-protein model trained presence/absence of gadolinium-positive (Gd+) lesions also strongly associated with new/enlarging T2 lesions, active versus stable (composite radiographic clinical evidence DA) improved performance (p < 0.05) compared...