A5080393861- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Obesity, Physical Activity, Diet
- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Cardiovascular Health and Risk Factors
- Frailty in Older Adults
- Cerebrovascular and Carotid Artery Diseases
- Urban Transport and Accessibility
- Pharmaceutical Practices and Patient Outcomes
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Opioid Use Disorder Treatment
- SARS-CoV-2 detection and testing
- Pain Management and Opioid Use
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Data-Driven Disease Surveillance
- Gender Roles and Identity Studies
- Statistical Methods and Bayesian Inference
- COVID-19 epidemiological studies
- Blood Pressure and Hypertension Studies
- Polyomavirus and related diseases
University of Massachusetts Chan Medical School
2018-2025
Memorial Medical Center
2024
UMass Memorial Medical Center
2024
Morningside College
2022
University of Michigan
2010-2021
National Institutes of Health
2019-2021
National Institute of Mental Health
2021
Texas A&M University – Corpus Christi
2016
Idera Pharmaceuticals (United States)
2016
Michigan Medicine
2014-2015
Objective To determine trends in ischemic stroke incidence among Mexican Americans and non‐Hispanic whites. Methods We performed population‐based surveillance from January 1, 2000 to December 31, 2010 Corpus Christi, Texas. Ischemic patients 45 years older were ascertained potential sources, charts abstracted. Neurologists validated cases based on source documentation blinded ethnicity age. Crude age‐, sex‐, ethnicity‐adjusted annual was calculated for first ever completed stroke. Poisson...
Our objective was to compare neurological, functional, and cognitive stroke outcomes in Mexican Americans (MAs) non-Hispanic whites using data from a population-based study.Ischemic strokes (2008-2012) were identified the Brain Attack Surveillance Corpus Christi (BASIC) Project. Data collected patient or proxy interviews (conducted at baseline 90 days poststroke) medical records. Ethnic differences neurological (National Institutes of Health Stroke Scale: range, 0-44; higher scores worse),...
Our objective was to identify factors that contribute or modify the sex difference in poststroke functional outcome.Ischemic strokes (n=439) were identified from Brain Attack Surveillance Corpus Christi (BASIC) Project (2008-2011). Data ascertained interviews (baseline and 90 days post stroke) medical records. Functional outcome measured as an average of 22 activities daily living (ADL)/instrumental ADL items (range, 1-4; higher scores worse function). Tobit regression used estimate...
Socioeconomic disadvantage is associated with poor health outcomes. However, whether socioeconomic factors are post-myocardial infarction (MI) outcomes in younger patient populations unknown.To evaluate the association of neighborhood-level long-term among patients who experienced an MI at a young age.This cohort study analyzed Mass General Brigham YOUNG-MI Registry (at and Women's Hospital Massachusetts Boston, Massachusetts) or before 50 years age between January 1, 2000, April 30, 2016....
We examined whether new policies restricting sales in schools of so-called competitive foods and beverages—those that fall outside what is served through federally reimbursed school meal programs—influenced increasing rates overweight children the Los Angeles Unified School District rest California. After these policies, which set stricter nutrition standards for certain food beverages sold to students, took effect, rate increase significantly diminished among fifth graders fifth-grade boys...
<h3>BACKGROUND AND PURPOSE:</h3> Mechanical thrombectomy with a stent retriever applied shortly after symptom onset could increase good functional outcomes and improve survival in patients acute basilar artery occlusion, but this has not yet been studied. This study evaluated the efficacy safety of mechanical Solitaire within 8 hours stroke occlusion. <h3>MATERIALS METHODS:</h3> We analyzed 25 consecutive occlusion who were treated by use onset. Successful recanalization was defined as TICI...
Background— The prevalence of severe obesity is rising in the United States. Although mild to moderately elevated body mass index (BMI) associated with reduced mortality after acute ischemic stroke, less known about obesity. Methods and Results— Patients stroke (n=1791) ≥45 years were identified from biethnic population–based Brain Attack Surveillance Corpus Christi (BASIC) study June 1, 2005, December 31, 2010. Median follow-up was 660 days. BMI abstracted medical record. Survival estimated...
To evaluate the use and tolerability of noninvasive positive pressure ventilation (NIV) in patients with amyotrophic lateral sclerosis (ALS) early their disease by comparing active NIV sham not yet eligible for as recommended practice guidelines.This was a single-center, prospective, double-blind, randomized, placebo (sham)-controlled pilot trial. Patients ALS were randomized to receive either or underwent surveillance approximately every 3 months until they reached forced vital capacity...
Paramagnetic rims have been observed as a feature of some multiple sclerosis (MS) lesions on susceptibility-sensitive magnetic resonance imaging (MRI) and indicate compartmentalized inflammation.
Abstract Background U.S. nursing homes provide long-term care to over 1.2 million older adults, 60% of whom were physically frail and 68% had moderate or severe cognitive impairment. Limited research has examined the longitudinal experience these two conditions in home residents. Methods This national study included newly-admitted non-skilled residents who Minimum Data Set (MDS) 3.0 (2014–16) assessments at admission, 3 months, 6 months ( n = 266,001). Physical frailty was measured by...
Accumulating evidence links structural sexism to gendered health inequities, yet methodological challenges have precluded comprehensive examinations into life-course and/or intersectional effects. To help address this gap, we introduce an analytic framework that uses sequential conditional mean models (SCMMs) jointly account for longitudinal exposure trajectories and moderation by multiple dimensions of social identity/position, which then apply study how early U.S. state-level shapes mental...
We explored whether a magnetic resonance imaging (MRI)-based composite score of bone marrow lesion and effusion-synovitis volumes related to contralateral knee osteoarthritis disease severity. Using data from the Osteoarthritis Initiative, we conducted cross-sectional knee-based analyses among participants with bilateral MRIs at least one Kellgren-Lawrence (KL) grade ≥1 WOMAC pain ≥10/100 (n = 693). Bone on were used calculate ("disease activity"). divided activity into tertiles....
ABSTRACT Background For patients with continued pain while receiving an initial course of a short‐acting opioid (SAO), clinicians may intensify the regimen by escalating SAO dose or initiating long‐acting (LAO). The objective this study was to assess comparative safety intensification regimens in nursing home residents nonmalignant pain. Methods We conducted retrospective cohort analysis US long‐stay identified from national Minimum Data Set (MDS) 3.0 and linked Medicare data, 2011–2016....
Epidemiologic studies have observed influences of the food environment near schools on children’s overweight status but not systematically assessed associations by race, sex, and grade. The authors examined whether between franchised fast restaurant or convenience store density varied these factors using data for 926,018 children (31.3% white, 55.1% Hispanic, 5.7% black, 8% Asian) in fifth, seventh, ninth grade, nested 6,362 schools. Cross-sectional were from 2007 California physical fitness...
Innovative strategies are needed to reduce the hypertension epidemic among African Americans. Reach Out was a faith-collaborative, mobile health, randomized, pilot intervention trial of four health components high blood pressure (BP) compared usual care. It designed and tested within community-based participatory research framework Americans recruited randomized from churches in Flint, Michigan. The purpose this study assess feasibility processes. Feasibility assessed by willingness consent...
In older US nursing home (NH) residents, there is limited research on the prevalence of physical frailty, its potential dynamic changes, and association with cognitive impairment in adults' first 6 months NH stay.
Background Accelerated biological aging is an increasingly popular way to track the acceleration of biology over time that may not be captured by calendar time. Biological has been linked external and internal chronic stressors potential used clinically understand a person's personalized functioning predict future disease. We compared association different measures incident cardiovascular disease (CVD) overall race. Methods Results multiple informants models compare strength clinical...
Built environment factors constrain individual level behaviors and choices, thus are receiving increasing attention to assess their influence on health. Traditional regression methods have been widely used examine associations between built measures health outcomes, where a fixed, prespecified spatial scale (e.g., 1 mile buffer) is construct measures. However, the for these remains largely unknown misspecifying it introduces bias. We propose use of distributed lag models (DLMs) describe...