A5019474973- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Ultrasound Imaging and Elastography
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Polyomavirus and related diseases
- Bone and Joint Diseases
- Brain Tumor Detection and Classification
- Migraine and Headache Studies
- Platelet Disorders and Treatments
- Alzheimer's disease research and treatments
- Photoacoustic and Ultrasonic Imaging
- Rheumatoid Arthritis Research and Therapies
- MRI in cancer diagnosis
- Medical Imaging and Analysis
- Psychosomatic Disorders and Their Treatments
- Trigeminal Neuralgia and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
Athinoula A. Martinos Center for Biomedical Imaging
2016-2025
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
John Wiley & Sons (United States)
2020
Hudson Institute
2020
St. Michael's Hospital
2019
University of Southern California
2019
Johns Hopkins University
2019
Boston University
2012-2016
Beth Israel Deaconess Medical Center
2009-2015
Abstract Objective: The periaqueductal gray matter (PAG), a known modulator of somatic pain transmission, shows evidence interictal functional and structural abnormalities in migraineurs, which may contribute to hyperexcitability along spinal trigeminal nociceptive pathways, lead the migraine attack. aim this study was examine connectivity PAG migraine. Methods: Using resting‐state MRI, we compared between subset brain areas involved nociceptive/somatosensory processing modulation 17...
In multiple sclerosis (MS), using simultaneous magnetic resonance-positron emission tomography (MR-PET) imaging with 11 C-PBR28, we quantified expression of the 18kDa translocator protein (TSPO), a marker activated microglia/macrophages, in cortex, cortical lesions, deep gray matter (GM), white (WM) and normal-appearing WM (NAWM) to investigate vivo pathological clinical relevance neuroinflammation.Fifteen secondary-progressive MS (SPMS) patients, 12 relapsing-remitting (RRMS) 14 matched...
Neuroaxonal pathology is a main determinant of disease progression in multiple sclerosis; however, its underlying pathophysiological mechanisms, including link to inflammatory demyelination and temporal occurrence the course are still unknown. We used ultra-high field (7 T), gradient strength diffusion T1/T2-weighted myelin-sensitive magnetic resonance imaging characterize microstructural changes myelin neuroaxonal integrity cortex white matter early stage sclerosis, their distribution...
We used ultra-high field MRI to visualize cortical lesion types described by neuropathology in 16 patients with multiple sclerosis (MS) compared 8 age-matched controls; characterize the contrast properties of lesions including T2*, T2, T1, and phase images; investigate relationship between clinical data.We collected, on a 7-T scanner, 2-dimensional fast low-angle shot (FLASH)-T2*-weighted spoiled gradient-echo, T2-weighted turbo spin-echo (TSE) images (0.33 x 033 1 mm(3)), 3-dimensional...
We used a surface-based analysis of T2* relaxation rates at 7 T magnetic resonance imaging, which allows sampling quantitative throughout the cortical width, to map in vivo spatial distribution intracortical pathology multiple sclerosis. Ultra-high resolution maps were obtained 10 subjects with clinically isolated syndrome/early sclerosis (≤3 years disease duration), 18 relapsing-remitting (≥4 13 secondary progressive sclerosis, and 17 age-matched healthy controls. Quantitative registered...
Background Migraine is a neurovascular disorder in which altered functional connectivity between pain-modulating circuits and the limbic system may play role. Cortical spreading depression (CSD), underlies migraine aura (MWA), induces C-fos expression amygdala. The role of CSD amygdala without (MwoA) less clear differentiate from other chronic pain disorders. Methods Using resting-state MRI, we compared cortex MWA MWoA patients as well healthy subjects two conditions not associated with CSD:...
Evaluate cross-sectionally the contribution of focal cortical lesion (CL) subtypes at ultra-high-field MRI and traditional metrics brain damage to neurologic disability cognitive performance in a heterogeneous multiple sclerosis (MS) cohort.Thirty-four patients with early or established disease including clinically isolated syndrome, relapsing-remitting MS, secondary progressive MS were scanned on human 7-tesla (7T) (Siemens) scanner acquire fast low-angle shot (FLASH) T2*-weighted images...
To determine if migraine with aura is associated neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well imaging human pain conditions.Thirteen migraineurs and 16 healthy controls received integrated PET/MRI brain scans [11C]PBR28, a radioligand that binds to the 18 kDa translocator protein, marker glial activation. Standardized uptake value ratio (SUVR) was compared between groups, regressed against clinical variables, using region...
Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that location may be a contributor. Our aim was explore the spatial distribution of sclerosis in cervical spinal cord, respect status. We included 642 suspected or confirmed patients (31 clinically isolated syndrome, 416 relapsing-remitting, 84 secondary progressive, 73...
Cortical spreading depression (CSD) underlies the neurobiology of migraine with aura (MWA). Animal studies reveal networks microvessels linking brain-meninges-bone marrow. CSD activates trigeminovascular system, evoking a meningeal inflammatory response. Accordingly, this study examines upregulation an marker in extra-axial tissues visual aura.We used simultaneously acquired 11 C-PBR28 positron emission tomography/magnetic resonance imaging data 18kDa translocator protein (an marker) MWA...
To characterize [11 C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS) and primary (PLS). We have previously shown increased the precentral gyrus a small group of ALS patients. Herein, we confirm our initial finding, study longitudinal changes, gray versus white matter distribution larger cohort patients PLS.Eighty-five participants including 53 ALS, 11 PLS, 21 healthy controls underwent integrated PET-magnetic resonance imaging....
Background Cortical lesions develop early in multiple sclerosis (MS) and play a major role disease progression. MRI at 7.0 T shows high sensitivity for detection of cortical as well better spatial resolution signal-to-noise ratio compared with lower field strengths. Purpose To longitudinally characterize
Abstract Although multiple sclerosis has traditionally been considered a white matter disease, extensive research documents the presence and importance of grey injury including cortical deep regions. The exhibits broad range pathology is uniquely suited to study mechanisms clinical relevance tissue in using magnetic resonance techniques. Deep associated with cognitive disability. Recently, MRI characterization properties, such as thalamic volume, have tested potential trial end points...
Abstract Functional MRI (fMRI) studies have shown increased activation of ipsilateral motor areas during hand movement in patients with multiple sclerosis (MS). We hypothesized that these changes could be due to disruption transcallosal inhibitory pathways. studied 18 relapsing‐remitting MS. Conventional T1‐ and T2‐weighted images were acquired lesion load (LL) measured. Diffusion tensor imaging (DTI) was performed estimate fractional anisotropy (FA) mean diffusivity (MD) the body corpus...
Abstract Purpose: To evaluate the inter‐rater agreement of cortical lesion detection using 7 Tesla (T) FLASH‐T2* and 3T DIR sequences. Materials Methods: Twenty‐six patients with multiple sclerosis were scanned on a human 7T (Siemens) MRI (TIM Trio, Siemens) to acquire DIR/MEMPR Four independent reviewers scored categorized lesions in bilateral precentral gyri (motor strips) as leukocortical, intracortical, or subpial. Inter‐rater was assessed according category kappa statistic. The...