A5006080988- Multiple Sclerosis Research Studies
- Scottish History and National Identity
- Irish and British Studies
- American Constitutional Law and Politics
- Historical Economic and Social Studies
- Historical Studies of British Isles
- Medical Imaging and Analysis
- Peripheral Neuropathies and Disorders
- Epilepsy research and treatment
- Brain Tumor Detection and Classification
- Cervical and Thoracic Myelopathy
- Genomics and Rare Diseases
- Reformation and Early Modern Christianity
- Glioma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Ultrasound Imaging and Elastography
- Australian History and Society
- Genetics and Neurodevelopmental Disorders
- Political Systems and Governance
- Polyomavirus and related diseases
- AI in cancer detection
- Bone and Joint Diseases
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Effects of Vibration on Health
St. James's Hospital
2023-2025
Trinity College Dublin
2023-2025
Beaumont Hospital
2009-2024
Trinity College
2024
St. James Hospital and Health Centers
2024
Royal College of Surgeons in Ireland
2018-2024
Science Foundation Ireland
2024
Hertie Institute for Clinical Brain Research
2022
University of Tübingen
2022
St. Vincent's University Hospital
2007-2022
Abstract The Human Phenotype Ontology (HPO, https://hpo.jax.org) was launched in 2008 to provide a comprehensive logical standard describe and computationally analyze phenotypic abnormalities found human disease. HPO is now worldwide for phenotype exchange. has grown steadily since its inception due considerable contributions from clinical experts researchers diverse range of disciplines. Here, we present recent major extensions the neurology, nephrology, immunology, pulmonology, newborn...
To understand the English (or Puritan) Revolution and Civil War, struggles which tore England apart in mid 17th century, one needs to Puritanism. This book cuts through misconceptions show Puritanism as a living faith answering hopes fears of yeomen gentlemen, merchants artisans. Professor Hill looks at all major i ssues time - oath-taking Sabbath, bawdy courts poor relief considers Puritan stress on household (rather that parish) dignity labour. The author also wrote World Upside Down.
Background: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it relevant to how we monitor and treat the disease. Objectives: The Magnetic Imaging MS (MAGNIMS) collaborative group sought determine relationship brain lesion load, spinal cord atrophy, with physical patients long-established MS. Methods: Patients had magnetic resonance imaging (MRI) scan their cord, from which determined grey (GMF) white matter (WMF) fractional volumes, upper cervical...
To investigate whether spinal cord (SC) lesion load, when quantified on axial images with high in-plane resolution, is associated disability in multiple sclerosis (MS).Twenty-eight healthy controls and 92 people MS had cervical SC 3T MRI phase sensitive inversion recovery, T2, magnetization transfer (MT) sequences. We outlined all visible focal lesions from C2 to C4 obtain load also measured upper area. MT ratio normal-appearing tissue lesions. Disability was recorded using the Expanded...
Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that location may be a contributor. Our aim was explore the spatial distribution of sclerosis in cervical spinal cord, respect status. We included 642 suspected or confirmed patients (31 clinically isolated syndrome, 416 relapsing-remitting, 84 secondary progressive, 73...
<b>Aim:</b> The aims of this study were to determine the reliability, responsiveness and minimally important change score Multiple Sclerosis Impact Scale (MSIS)-29 physical using Expanded Disability Status (EDSS) as an anchor measure. <b>Methods:</b> 214 patients with multiple sclerosis (MS) (EDSS 0–8.5) had concurrent MSIS-29 EDSS assessments at baseline up 4 years follow-up. <b>Results:</b> 116 unchanged scores. Stability (mean 0.1 points) was better in 85 0–5.0 than 31 5.5–8.5 whom fell...
Purpose To identify an improved method for measuring spinal cord cross‐sectional area (CSA) using magnetic resonance imaging (MRI) in multiple sclerosis (MS). Materials and Methods MRI was performed on 15 controls MS patients repeated nine after 6 months. At this timepoint, additional scan acquired to evaluate scan–rescan reproducibility. Two sequences were the cervical cord: 3D phase sensitive inversion recovery (PSIR) magnetization prepared rapid acquisition T1‐weighted gradient echo. CSA...
<h3>Background</h3> In multiple sclerosis (MS), pathological studies have identified substantial demyelination and neuronal loss in the spinal cord grey matter (GM). However, there has been limited vivo investigation of GM abnormalities their possible functional effects using MRI combined with clinical evaluation. <h3>Methods</h3> We recruited healthy controls (HC) people a clinically isolated syndrome (CIS), relapsing remitting (RR) secondary progressive (SP) MS. All subjects had 3 T...
Various types of epilepsy are a leading cause neurological disability worldwide; they have in common propensity to recurrent unprovoked seizures. There is increasing interest the concept precision medicine for therapy. While treatment aimed at level an ion channel or single pathway has provided benefits small number individuals with genetically mediated cases, high-definition approach extending beyond genes broader array personalized factors may improve outcomes.Advances sequencing...
Gay matter (GM) involvement is clinically relevant in multiple sclerosis (MS). Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year evolution across different MS phenotypes.Clinical MRI data were obtained at 8 European sites from 170 healthy controls (HCs) 398 patients with (34 isolated syndrome [CIS], 226 relapsing-remitting [RRMS], 95 secondary progressive [SPMS], 43 primary [PPMS]). Fifty-seven HCs 144 underwent follow-up. Baseline loss, progression,...
Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI). However, methods have been limited factors relating to reproducibility or sensitivity change. The purpose this study was evaluate fully automated method (PropSeg), and compare semi-automated active surface (AS) method, healthy controls (HC) people with multiple sclerosis (MS). MRI data from 120 were retrospectively...
To characterize the distribution and regional evolution of cervical cord atrophy in patients with multiple sclerosis (MS) a multicenter dataset.MRI clinical evaluations were acquired from 179 controls 435 (35 clinically isolated syndromes [CIS], 259 relapsing-remitting [RRMS], 99 secondary progressive [SPMS], 42 primary [PPMS]). Sixty-nine 178 underwent 1-year MRI follow-up. Patients classified as stable/worsened according to their disability change. Longitudinal changes investigated linear...
The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology malformations cortical development. aim this study was determine diagnostic yield genes that have previously associated with a or germline model, ascertained from resected brain tissue patients multidrug-resistant focal epilepsy.