A5051943836- Amyotrophic Lateral Sclerosis Research
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Parkinson's Disease Mechanisms and Treatments
- Mindfulness and Compassion Interventions
- Genetic Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Neurological and metabolic disorders
- Neurogenetic and Muscular Disorders Research
- Behavioral and Psychological Studies
- Psychological Treatments and Assessments
- Cardiac Health and Mental Health
- Child and Animal Learning Development
- Stress Responses and Cortisol
- Language Development and Disorders
- Family Dynamics and Relationships
- Psychology of Development and Education
- Child Welfare and Adoption
- Educational and Psychological Assessments
- Treatment of Major Depression
University of North Carolina at Chapel Hill
2018-2024
Google (United States)
2024
Clinical Research Institute
2016-2021
Massachusetts General Hospital
2016-2021
Harvard University
2017-2018
Tufts University
2017
To characterize [11 C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS) and primary (PLS). We have previously shown increased the precentral gyrus a small group of ALS patients. Herein, we confirm our initial finding, study longitudinal changes, gray versus white matter distribution larger cohort patients PLS.Eighty-five participants including 53 ALS, 11 PLS, 21 healthy controls underwent integrated PET-magnetic resonance imaging....
In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation glial activation the same cohort of participants.Ten individuals with amyotrophic lateral sclerosis (ALS) and 10 matched healthy controls underwent imaging using integrated MR/PET radioligand [11C]-PBR28. Diagnosis history clinical assessments including Upper Motor Neuron Burden Scale (UMNB) were obtained from patients ALS. Diffusion tensor (DTI) analyses tract-based spatial statistics tractography...
Abstract The social motivation hypothesis of autism posits that spectrum disorder (ASD) is characterized by impaired to seek out experience early in life interferes with the development functioning. This framework suggests mesolimbic dopamine function underlies compromised responses rewards ASD. Although this supported functional magnetic resonance imaging (fMRI) studies, no molecular study has evaluated striatal functioning response Here, we examined during monetary incentive processing ASD...
To determine the relationship between brain tissue metabolites measured by in vivo magnetic resonance spectroscopy (1H-MRS), and glial activation assessed with [11C]-PBR28 uptake people amyotrophic lateral sclerosis (ALS).Forty ALS participants were evaluated clinically using revised functional rating scale (ALSFRS-R) upper motor neuron burden (UMNB). All underwent simultaneous PET MR imaging including diffusion tensor to acquire fractional anisotropy (FA). was as standardized values...
The main objective of this study was to utilize high field (7T) in vivo proton magnetic resonance imaging increase the ability detect metabolite changes people with ALS, specifically, quantify levels glutamine and separately. second correlate metabolic markers clinical outcomes disease progression. 13 ALS participants 12 age-matched healthy controls (HC) underwent 7 Tesla MRI MRS. Single voxel MR spectra were acquired from left precentral gyrus using a very short echo time (TE = 5 ms) STEAM...
Autism spectrum disorder (ASD) is characterized by impaired predictive abilities; however, the neural mechanisms subsuming reward prediction errors in ASD are poorly understood. In current study, we investigated responses during social and nonsocial 22 adolescents with (ages 12–17) 20 typically developing control 12–18). Participants performed a error task using both (i.e., faces) objects) rewards functional magnetic resonance imaging scan. Reward were defined two ways: (a) signed error,...
Glia activation is thought to contribute neuronal damage in several neurodegenerative diseases based on preclinical and human post-mortem studies, but its role primary lateral sclerosis (PLS) unknown. To localize measure glia people with PLS compared healthy controls (HC). Ten participants ten age-matched HCs underwent simultaneous magnetic resonance (MR) proton emission tomography (PET). The radiotracer [11C]-PBR28 was used obtain PET-based measures of 18 kDa translocator protein (TSPO)...
Purpose: This study examined the impact of bilingualism on affective theory mind (ToM) and social prioritization (SP) among autistic adults compared to neurotypical comparison participants. Method: Fifty-two (25 autistic, 27 neurotypical) adult participants (ages 21–35 years) with varying second language (L2) experience, ranging from monolingual bilingual, completed an ToM task. A subset this sample also a dynamic eye-tracking task designed capture differences in time spent looking at...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in progressive loss motor function and ultimately death. It critical, yet also challenging, to develop non-invasive biomarkers identify, localize, measure and/or track biological mechanisms implicated ALS. Such may provide clues identify potential molecular targets for future therapeutic trials. Herein we report on pilot study involving twelve participants with ALS nine age-matched...
Few studies have explored neural mechanisms of reward learning in ASD despite evidence behavioral impairments predictive abilities ASD. To investigate the correlates prediction errors ASD, 16 adults with and 14 typically developing controls performed a error task during fMRI scanning. Results revealed greater activation group left paracingulate gyrus signed insula right frontal pole thresholded unsigned errors. Findings support atypical processing frontostriatal regions critical for coding...
Research has consistently demonstrated that testing prior to the presentation of misleading post-event information, within context a standard eyewitness misinformation paradigm, results in an increase effect. The present study investigated whether changes susceptibility interim are affected by retention interval differences between and final testing. Further, this tested possible divergences original learning conditions where elaboration processing critical details was encouraged either...
There is an unmet need for mechanism-based biomarkers and effective disease modifying treatments in amyotrophic lateral sclerosis (ALS). Previous findings have provided evidence that histone deacetylases (HDAC) are altered ALS, providing a rationale testing HDAC inhibitors as therapeutic option.We measured class I II protein transcript levels together with acetylation of downstream substrates by using Western blotting postmortem tissue ALS controls. [11 C]Martinostat, novel positron emission...
Abstract Background Chronic stress alters reward sensitivity and contributes to the emergence of anhedonia. In clinical samples, perception is a strong predictor While there substantial evidence demonstrating psychotherapy reduces perceived stress, little known regarding effects treatment-related decreases in on Methods The current study investigated reciprocal relations between anhedonia using cross-lagged panel model approach 15-week trial examining Behavioral Activation Treatment for...
Abstract Background Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples major depressive disorder. The purpose of this study was examine linkages between striatal DA binding, reward circuitry functioning, anhedonia, and, an exploratory fashion, self-reported stress, a transdiagnostic anhedonic sample. Methods Participants (n=25) and without (n=12) clinically impairing anhedonia completed reward-processing task during simultaneous...