A5053723979- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Diversity and Career in Medicine
- Innovations in Medical Education
- Atomic and Subatomic Physics Research
- Global Health Workforce Issues
- Radiology practices and education
- Parkinson's Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Pain Mechanisms and Treatments
- Advanced X-ray and CT Imaging
- Advances in Oncology and Radiotherapy
- Lanthanide and Transition Metal Complexes
- Alzheimer's disease research and treatments
- Pain Management and Placebo Effect
- Medical Education and Admissions
- Anesthesia and Sedative Agents
- Healthcare Policy and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Connective tissue disorders research
- ECG Monitoring and Analysis
Harvard University
2012-2023
Massachusetts General Hospital
2013-2023
Athinoula A. Martinos Center for Biomedical Imaging
2012-2022
Boston University
2022
Massachusetts Institute of Technology
2014-2018
Harvard Bioscience (United States)
2018
Clinical Research Institute
2016
Harvard–MIT Division of Health Sciences and Technology
2013
Although substantial evidence has established that microglia and astrocytes play a key role in the establishment maintenance of persistent pain animal models, glial cells human disorders remains unknown. Here, using novel technology integrated positron emission tomography-magnetic resonance imaging recently developed radioligand (11)C-PBR28, we show increased brain levels translocator protein (TSPO), marker activation, patients with chronic low back pain. As Ala147Thr polymorphism TSPO gene...
Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system activated microglia pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate neuroinflammation individuals with sclerosis using [11C]-PBR28 positron emission tomography. Ten patients (seven males, three females, 38–68 years) ten age- binding affinity-matched healthy volunteers (six four 33–65 completed a tomography scan. Standardized uptake values were calculated 60 90...
We present an approach for head MR-based attenuation correction (AC) based on the Statistical Parametric Mapping 8 (SPM8) software, which combines segmentation- and atlas-based features to provide a robust technique generate maps (μ maps) from MR data in integrated PET/MR scanners.Coregistered anatomic CT images of 15 glioblastoma subjects were used templates. The these first segmented into 6 tissue classes (gray matter, white cerebrospinal fluid, bone, soft tissue, air), then nonrigidly...
Head motion is difficult to avoid in long PET studies, degrading the image quality and offsetting benefit of using a high-resolution scanner. As potential solution an integrated MR-PET scanner, simultaneously acquired MRI data can be used for tracking. In this work, novel algorithm processing rigid-body correction (MC) MRI-compatible BrainPET prototype scanner described, proof-of-principle phantom human studies are presented.To account motion, prompt random coincidences sensitivity...
Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism unconsciousness. By using novel combination positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness recovery α2-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate glucose blood flow were preferentially decreased thalamus, Default Mode...
To characterize [11 C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS) and primary (PLS). We have previously shown increased the precentral gyrus a small group of ALS patients. Herein, we confirm our initial finding, study longitudinal changes, gray versus white matter distribution larger cohort patients PLS.Eighty-five participants including 53 ALS, 11 PLS, 21 healthy controls underwent integrated PET-magnetic resonance imaging....
In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation glial activation the same cohort of participants.Ten individuals with amyotrophic lateral sclerosis (ALS) and 10 matched healthy controls underwent imaging using integrated MR/PET radioligand [11C]-PBR28. Diagnosis history clinical assessments including Upper Motor Neuron Burden Scale (UMNB) were obtained from patients ALS. Diffusion tensor (DTI) analyses tract-based spatial statistics tractography...
Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of scale the level cortical networks and coordinate their interplay during memory. Among network territories, mean D1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network regulation. Indeed, density...
Abstract Mechanisms of neuroimmune and mitochondrial dysfunction have been repeatedly implicated in autism spectrum disorder (ASD). To examine these mechanisms ASD individuals, we measured the vivo expression 18 kDa translocator protein (TSPO), an activated glial marker expressed on membranes. Participants underwent scanning a simultaneous magnetic resonance–positron emission tomography (MR–PET) scanner with second-generation TSPO radiotracer [ 11 C]PBR28. By comparing 15 young adult males...
There is an ongoing effort to develop better methods for noninvasive detection and characterization of thrombi. Here we describe the synthesis evaluation three new fibrin-targeted positron emission tomography (PET) probes (FBP1, FBP2, FBP3). Three fibrin-specific peptides were conjugated as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-monoamides at C- N-termini chelated with 64CuCl2. Probes prepared a specific activity ranging from 10 130 μCi/nmol. Both exhibited nanomolar...
Background Subject motion in positron emission tomography (PET) studies leads to image blurring and artifacts; simultaneously acquired magnetic resonance imaging (MRI) data provides a means for correction (MC) integrated PET/MRI scanners. Purpose To assess the effect of realistic head MR‐based MC on static [ 18 F]‐fluorodeoxyglucose (FDG) PET images dementia patients. Study Type Observational study. Population Thirty subjects were recruited. Field Strength/Sequence 3T hybrid PET/MR scanner...
Purpose Simultaneous acquisition of MR and positron emission tomography (PET) images requires the placement detection coil inside PET detector ring where it absorbs scatters photons. This constraint is principal barrier to achieving optimum sensitivity on each modality. Here, we present a 31‐channel PET‐compatible brain array with reduced attenuation but improved sensitivity. Methods A series component tests were performed identify tradeoffs between performance. Aspects studied include...
Glia activation is thought to contribute neuronal damage in several neurodegenerative diseases based on preclinical and human post-mortem studies, but its role primary lateral sclerosis (PLS) unknown. To localize measure glia people with PLS compared healthy controls (HC). Ten participants ten age-matched HCs underwent simultaneous magnetic resonance (MR) proton emission tomography (PET). The radiotracer [11C]-PBR28 was used obtain PET-based measures of 18 kDa translocator protein (TSPO)...
Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct reporters at C- and N-termini. In vitro studies demonstrated retention fibrin affinity specificity. Imaging showed that these probes could detect over wide range probe concentrations by optical, magnetic resonance, positron emission tomography imaging.
A main advantage of PET is that it provides quantitative measures the radiotracer concentration, but its accuracy confounded by factors including attenuation, subject motion, and limited spatial resolution. Using information from one simultaneously acquired morphologic MR sequence with embedded navigators for motion correction (MC), we propose an efficient method, MR-assisted data optimization (MaPET), attenuation (AC), MC, anatomy-aided reconstruction. <b>Methods:</b> For AC, voxelwise...
Integrated scanners capable of simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) data acquisition are now available for human use. Although the scanners’ manufacturers have made substantial efforts to understand minimize mutual electromagnetic interference between 2 modalities, potential physiological inference has not been evaluated. In this study, we studied influence acoustic noise produced by (MR) gradients on brain fludeoxyglucose (FDG) uptake in...
Kinetic parameters estimated from dynamic (18)F-fluorodeoxyglucose ((18)F-FDG) PET acquisitions have been used frequently to assess brain function in humans. Neglecting partial volume correction (PVC) for a series has shown produce significant bias model estimates. Accurate PVC requires space-variant describing the reconstructed image spatial point spread (PSF) that accounts resolution limitations, including non-uniformities across field of view due parallax effect. For ordered subsets...
Pain interventions with no active ingredient, placebo, are sometimes effective in treating chronic pain conditions. Prior studies on the neurobiological underpinnings of placebo analgesia indicate endogenous opioid release and changes brain responses functional connectivity during anticipation experience healthy subjects. Here, we investigated subjects interictal migraine patients (n = 9) matched controls using 11C-diprenoprhine Positron Emission Tomography (PET) simultaneous Magnetic...