A5036832777- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- RNA and protein synthesis mechanisms
- Radiation Detection and Scintillator Technologies
- Advanced X-ray and CT Imaging
- Genomics and Phylogenetic Studies
- Radiomics and Machine Learning in Medical Imaging
- Bacteriophages and microbial interactions
- Linguistics and Discourse Analysis
- Machine Learning in Bioinformatics
- Advanced Radiotherapy Techniques
- Fractal and DNA sequence analysis
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Bacterial Genetics and Biotechnology
- Cardiac Imaging and Diagnostics
- Historical and Literary Studies
- Advanced biosensing and bioanalysis techniques
- Historical Studies and Socio-cultural Analysis
- RNA Research and Splicing
- DNA and Biological Computing
- Genomics and Chromatin Dynamics
- European Political History Analysis
- Radiopharmaceutical Chemistry and Applications
- Particle Detector Development and Performance
Université de Strasbourg
2013-2024
Karlsruhe Institute of Technology
2024
Centre d'études des relations et des contacts linguistiques et littéraires
2017-2024
Université de Picardie Jules Verne
2016-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2015-2023
Universitätsklinikum Gießen und Marburg
2019-2023
University Hospital Heidelberg
2023
Heidelberg University
2023
Centre National de la Recherche Scientifique
2012-2021
Philipps University of Marburg
2019-2021
This paper presents two new rebinning algorithms for the reconstruction of three-dimensional (3-D) positron emission tomography (PET) data. A algorithm is one that first sorts 3-D data into an ordinary two-dimensional (2-D) set containing sinogram each transaxial slice to be reconstructed; image then recovered by applying a 2-D method such as filtered-backprojection. approach allows significant speedup reconstruction, which particularly useful applications involving dynamic acquisitions or...
The ECAT EXACT HR is a newly designed CTI-Siemens PET scanner with high spatial resolution. Its physical performance respect to resolution, count rate efficiency, and scatter was investigated evaluated phantom studies.The new tomograph consists of three rings 112 BGO block detectors (50 mm x 23 30 deep) each, covering an axial field view 15 cm patient port 56 diameter. Each sawed into 8 7 matrix giving 24 detector 784 crystals each.Total sensitivity for 20 cylinder 177 kcps/microCi/ml in...
The quality of images reconstructed by statistical iterative methods depends on an accurate model the relationship between image space and projection through system matrix elements for clinical Hi-Rez scanner were derived processing data measured a point source at different positions in portion field view. These included axial compression azimuthal interleaving adjacent projections. Measured corrected crystal geometrical efficiency. Then, whole was responses space. Such both detection...
The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging the human brain and skull base. PET ring consists lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted clinical 3-T MR imager use birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18...
The ECAT HRRT is a three-dimensional (3-D) only dedicated brain tomograph employing the new scintillator lutetium-oxy-orthosilicate (LSO) and using depth of interaction (DOI) information to achieve uniform isotropic resolution across 20-cm diameter volume. With its unique technological innovations it represents prototype generation high-resolution tomographs. physical performance with respect count rate, live time, scatter, sensitivity, was evaluated phantom studies measurements point...
Several factors have to be considered for implementing an accurate attenuation-correction (AC) method in a combined MR-PET scanner. In this work, some of these challenges were investigated, and AC based entirely on the MRI data obtained with single dedicated sequence was developed used neurologic studies performed human brain scanner prototype. <b>Methods:</b> The focus problem bone–air segmentation, selection linear attenuation coefficient bone, positioning radiofrequency coil. impact PET...
Abstract Background The Covid19 infection is caused by the SARS-CoV-2 virus, a novel member of coronavirus (CoV) family. CoV genomes code for ORF1a / ORF1ab polyprotein and four structural proteins widely studied as major drug targets. also contain variable number open reading frames (ORFs) coding accessory that are not essential virus replication, but appear to have role in pathogenesis. been less well characterized difficult predict classical bioinformatics methods. Methods We propose...
BACKGROUND Both [13N]ammonia and [15O]water have been used to quantify myocardial blood flow with positron emission tomography using appropriate tracer kinetic models. A direct comparison of the two tracers radioactive microspheres has not performed in same experimental preparation. METHODS AND RESULTS The tested for quantification closed-chest dogs circumflex coronary stenosis or permanent occlusion at rest during adenosine-induced hyperemia. [13N]ammonia- [15O]water-derived values compared...
Background Previous work has documented that dysfunctional noninfarcted collateral-dependent myocardium, a condition typical of myocardial hibernation, exhibited almost normal resting perfusion. The present study was designed to test whether these observations could be extended unselected patients with chronic dysfunction and previous infarction. Methods Results Dynamic positron emission tomographic imaging [ 13 N]ammonia 18 F]fluorodeoxy-glucose (FDG) assess perfusion glucose uptake...
In positron emission tomography (PET) and single photon (SPECT), attenuation correction is necessary for quantitative reconstruction of the tracer distribution. Previously, several attempts have been undertaken to estimate coefficients from data only. These had limited success, because problem does not a unique solution, severe persistent "cross-talk" between estimated activity distributions was observed. this paper, we show that availability TOF-information eliminates cross-talk by...
Head motion is difficult to avoid in long PET studies, degrading the image quality and offsetting benefit of using a high-resolution scanner. As potential solution an integrated MR-PET scanner, simultaneously acquired MRI data can be used for tracking. In this work, novel algorithm processing rigid-body correction (MC) MRI-compatible BrainPET prototype scanner described, proof-of-principle phantom human studies are presented.To account motion, prompt random coincidences sensitivity...
Positron emission tomographs (PETs) are currently almost exclusively designed as hybrid systems. The current standard is the PET/CT combination, while prototype PET/MRI systems being studied by several research groups. One problem in these that transaxial field-of-view of second system smaller than PET camera and does not provide complete attenuation data. Because this provides image for scatter correction, FOV causes truncation map, producing bias corrected activity image. In paper, we...
Objective In septic shock, decreased splanchnic blood flow is reported, despite adequate systemic hemodynamics. N-acetylcysteine (NAC) was found to increase hepatosplanchnic in experimental settings. shock patients, NAC improved the clearance of indocyanine green and relationship oxygen consumption demand. We investigated influence on liver flow, transport-related variables, function during early shock. Design Prospective, randomized, double-blind study. Setting Septic patients admitted an...
We present the results of utilizing aligned anatomical information from CT images to locally adjust image smoothness during reconstruction three-dimensional (3D) whole-body positron emission tomography (PET) data. The ability PET imaging detect malignant neoplasms is becoming widely recognized. Potentially useful, however, role in quantitative estimation tracer uptake. utility oncology often limited by high level statistical noise images. Reduction can be obtained incorporating a priori...
This paper presents the results of combining high sensitivity 3D PET whole-body acquisition followed by fast 2D iterative reconstruction methods based on accurate statistical models. combination is made possible Fourier rebinning (FORE), which accurately converts a data set to sinograms. The volume imaging with allows improvement noise-bias trade-offs when image quality dominated measurement statistics. acquired into reduces computation time reconstruction. For both penalized weighted least...
Time-of-flight (TOF) positron emission tomography (PET) was studied and preliminarily developed in the 1980s, but lack of a scintillator able to deliver at same time proper resolution stopping power has prevented this technique from becoming widespread commercially available. With introduction LSO PET, TOF is now feasible option. reconstruction been implemented CPS Hi-Rez PET scanner, both with 2D filtered-back-projection (FBP2D) 3D ordered subset expectation maximization (OSEM3D). A new...
With continuous improvements in spatial resolution of positron emission tomography (PET) scanners, small patient movements during PET imaging become a significant source degradation. This work explores incorporation motion information into expectation-maximization (EM) reconstruction algorithms. An important issue addressed is the existence lines-of-response (LORs) corresponding to no actual pairs detectors and their motion-induced "interaction" with detectable LORs. example this scanner...
Abstract A regional analysis of cerebral glucose metabolism was carried out in 9 patients with progressive supranuclear palsy by using positron emission tomography fluorodeoxyglucose as the tracer. consistent metabolic map frontal hypometabolism found 7 patients. Brain normal 1 subject and diffusely decreased another. In selective hypofrontality, motor premotor areas were severely hypometabolic, while heteromodal association cortex paralimbic regions comparatively less affected. Although...
High spatial resolution dynamic brain PET imaging with the ECAT HRRT scanner short frame durations is characterized by very few counts per sinogram bin due to small size of crystal surface. The use various weighting schemes for OSEM-3D can result in significantly different results. In particular, correction random and scattered coincidences prior reconstruction lead a systematic positive bias reconstructed image. We show that Ordinary Poisson OSEM-3D, where all corrections are applied during...