A5100393441- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Elbow and Forearm Trauma Treatment
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Shoulder Injury and Treatment
- Drug Transport and Resistance Mechanisms
- Pelvic and Acetabular Injuries
- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Bone Metabolism and Diseases
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Treatments and Mutations
- Shoulder and Clavicle Injuries
- Autoimmune Bullous Skin Diseases
- Radiomics and Machine Learning in Medical Imaging
- Foot and Ankle Surgery
- Neonatal Health and Biochemistry
- Bone Tissue Engineering Materials
- Acute Myocardial Infarction Research
- Hematological disorders and diagnostics
- Surgical site infection prevention
Nanjing Drum Tower Hospital
2014-2025
Nanjing University of Chinese Medicine
2020-2025
Emory University
2024-2025
Sanofi (United States)
2022-2025
Sichuan University
2023-2024
Shanghai Sixth People's Hospital
2022
Nanjing University
2010-2022
Second Affiliated Hospital of Nanjing Medical University
2022
University of California System
2022
Imaging Center
2022
PurposeThis trial aimed to assess the efficacy and safety of olipudase alfa enzyme replacement therapy for non–central nervous system manifestations acid sphingomyelinase deficiency (ASMD) in adults.MethodsA phase 2/3, 52 week, international, double-blind, placebo-controlled (ASCEND; NCT02004691/EudraCT 2015-000371-26) enrolled 36 adults with ASMD randomized 1:1 receive or placebo intravenously every 2 weeks intrapatient dose escalation 3 mg/kg. Primary endpoints were percent change from...
Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment.Irisin, newly discovered myokine adipokine, has been found to have beneficial effects on various cardiovascular diseases.However, the pharmacological effect of irisin antagonizing hypertension-induced vascular not well understood.In present study, we investigated protection mechanisms against induced by angiotensin II (Ang II).Adult male mice wild-type, FNDC5...
Abstract Background Pulsed electromagnetic field (PEMF) is reported to be an effective adjunct for the management of nonunion long-bone fractures. Most studies implement PEMF treatment after 6 months or longer delayed union following fracture treatment. Despite these variations in treatment, early application a diagnosis postoperative has not been specifically analyzed. In this study, outcomes fractures treated with were evaluated as compared sham-treated control group. Methods prospective,...
The optimal method for the reduction and fixation of posterior malleolar fracture (PMF) remains inconclusive. Currently, both indirect direct techniques are widely used. We aimed to compare quality clinical outcome managed with technique through posterolateral approach or using ligamentotaxis. Patients a PMF involving over 25% articular surface were recruited assigned (DR) group (IR) group. Following fracture, was evaluated in post-operative CT images. Clinical radiological follow-ups...
Abstract We have previously observed that knockout of Niemann-Pick C1-Like 1 (NPC1L1), a cholesterol transporter essential for intestinal absorption, reduces the output dry stool in mice. As food intake remains unaltered NPC1L1-knockout (L1-KO) mice, we hypothesized NPC1L1 deficiency may alter gut microbiome to reduce output. Consistently, here demonstrate phyla fecal microbiota differ substantially between L1-KO mice and their wild-type controls. Germ-free (GF) reduced Inhibition by its...
Minimally invasive percutaneous techniques offer a promising alternative to open surgical repair of the Achilles tendon. However, possibilities recurrent rupture and nerve complications remain. Hence, present study was conducted describe modified technique for tendon able overcome these limitations. This retrospective included 36 patients with acute closed treated at our institution between January 2020 2022. All underwent surgery were followed up 12-25 months. Functional evaluation based on...
The colonic motility is altered in patients with ulcerative colitis (UC), but the mechanism not clear. Carbon monoxide (CO) molecule regulating resting membrane potential (RMP) gradient across smooth muscle wall. Changes RMP will affect contractility of muscle. In this study, we investigated dextran sodium sulfate-induced UC mice and role CO. results showed that group, frequency spontaneous contractions was increased while AUC decreased compared to control group. HO-1, HO-2, positive cells...
Tolebrutinib is an oral, brain-penetrant, and bioactive Bruton's tyrosine kinase inhibitor that modulates peripheral inflammation persistent immune activation within the central nervous system, including disease-associated microglia B cells. More data are needed on its efficacy safety in treating relapsing multiple sclerosis. In two phase 3, double-blind, double-dummy, event-driven trials (GEMINI 1 GEMINI 2), participants with sclerosis were randomly assigned a 1:1 ratio to receive...
Abstract The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, supplemented drinking water 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal fat, Lee’s index, and liver cholesterol. Blood HDL-cholesterol increased, but total cholesterol aspartate transaminase decreased. Glucose insulin tolerances were improved, accompanying with fasting blood glucose,...
Abstract Background Unfavorable reduction is considered one of the key factors leading to joint degeneration and compromised clinical outcome in acetabular fracture patients. Besides columns, walls, superior dome, postoperative position hip center (HJC), which reported affect biomechanics, should be during assessment quality reduction. We aimed evaluate radiographic restoration HJC fractures treated with open internal fixation. Methods Patients a displaced that received fixation authors’...
Cement spacers (Masquelet technique) have traditionally been used for the treatment of segmental bone defects. However, no reports cement small/partial defects associated with osteomyelitis and compared outcomes beads. We retrospectively analysed 40 patients post-traumatic tibia who underwent treatment, which was performed in two stages. In first stage, thorough debridement performed, were filled either antibiotic-impregnated beads (bead group, 18 patients) or (spacer 22 patients). second...
Background: Venous thromboembolism (VTE) is a well-documented complication in patients with lower limb fractures, but management guidelines for its prevention isolated foot and ankle fracture are conflicting. The aim of this study was to conduct multicenter, prospective cohort define the prevalence VTE fractures determine whether routine prophylaxis necessary these patients. Methods: In double-blind, placebo-controlled study, consecutive 3 hospitals who met our criteria were enrolled. After...
Colorectal cancer (CRC) is the fourth most frequent type of malignancy in world. Metastasis accounts for >90% mortalities patients with CRC. The metastasis-associated colon 1 (MACC1) gene has been identified as a novel biomarker prediction metastasis and disease prognosis, particularly early-stage disease. Previous clinical studies demonstrated that MACC1 expression polymorphisms CRC tissues were indicators metastasis, circulating transcripts plasma also significantly associated survival...
Abstract Brain‐derived neurotrophic factor (BDNF) has been reported to participate in fracture healing, whereas the mechanism is still unclear. Since osteoblast migration important for investigating effects of BDNF on osteoblasts may help reveal its mechanism. Here, MC3T3‐E1 cells were used vitro while closed femur mice applied vivo. Cells was assessed with Transwell assay. The protein expression analysed by immunoblotting. X‐ray and Micro‐CT performed at different time after fracture. Our...
Abstract Background The ulnar styloid is an important supportive structure for the triangular fibrocartilage complex. However, it remains inconclusive whether or not a fractured should be fixed in unstable distal radius fracture (DRF) with stable radioulnar joint (DRUJ). purpose of this study to evaluate effect untreated on outcome DRF treated transarticular external fixation when DRUJ stable. Methods 106 patients and were included following fixation. divided into non-fracture, tip-fracture...
Background and Purpose The tumour suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome integrity. Recent studies have demonstrated that it contributes metabolic diseases. Here, we investigated the role of in regulation bile acid disposition cholestasis. Experimental Approach disposition‐related gene expression profile affected by activation was assessed mouse primary hepatocytes with depletion Trp53 ‐null mice. Dual luciferase reporter assay used detect...
Abstract Eukaryotic initiation factor 3 (EIF3) is one of the largest and most complex translation factors, which consists 13 subunits named eukaryotic subunit A (EIF3a) to EIF3m. EIF3a EIF3. Previous studies suggested that a housekeeping gene, recent results have found closely related tumorigenesis drug resistance. Circular RNAs (circRNAs) derived from biologically important gene can play an role in regulation. However, mechanism underlying circRNAs’ biological functions not well understood...