Abstract Background Pulsed electromagnetic field (PEMF) is reported to be an effective adjunct for the management of nonunion long-bone fractures. Most studies implement PEMF treatment after 6 months or longer delayed union following fracture treatment. Despite these variations in treatment, early application a diagnosis postoperative has not been specifically analyzed. In this study, outcomes fractures treated with were evaluated as compared sham-treated control group. Methods prospective,...

Abstract Background The aim of this study was to investigate the association insulin‐like growth factor‐1 receptor (IGF‐1R) with metastasis and prognosis osteosarcoma patients. Methods RT‐PCR Western blot assays were performed detect IGF‐1R mRNA protein expression in 26 noncancerous bone tissues. Immunohistochemistry analyze correlation 84 tissues clinicopathological factors or survival Lentivirus‐mediated RNA interference system employed downregulate effects downregulation on invasion...

The optimal method for the reduction and fixation of posterior malleolar fracture (PMF) remains inconclusive. Currently, both indirect direct techniques are widely used. We aimed to compare quality clinical outcome managed with technique through posterolateral approach or using ligamentotaxis. Patients a PMF involving over 25% articular surface were recruited assigned (DR) group (IR) group. Following fracture, was evaluated in post-operative CT images. Clinical radiological follow-ups...

Brain‑derived neurotrophic factor (BDNF), a member of the neurotropic family, is expressed in osteoblast‑like cells fracture callus, however, its role healing remains to be fully elucidated. Osteoblasts isolated from Sprague Dawley rats were stimulated by BDNF dose‑ and time‑dependent manner. Immunoblotting immunofluorescence was used detect expression distribution targeted proteins. The concentration vascular endothelial growth (VEGF) released medium determined using an ELISA. PD98059 K252a...

The Musculoskeletal Tumor Society (MSTS) scoring system is a disease-specific instrument to determine the physical and mental health for patients with extremity sarcoma. This study aims investigate reliability validity of Chinese version MSTS, evaluate functional outcomes surgical treatment lower sarcoma using MSTS. A cohort 98 who had undergone surgery were included. All completed clinical assessment MSTS Toronto Extremity Salvage Score (TESS). Assessment psychometric properties was carried...

Recurrence of giant cell tumor bone (GCTB) in the soft tissue is rarely seen clinical practice. This study aims to determine prevalence recurrence GCTB, and characterize its radiographic features.A total 291 patients treated by intralesional curettage for histologically diagnosed GCTB were reviewed. 6 identified have tissue, all whom had undergone marginal resection lesion. Based on x-ray, CT MRI imaging, features classified into 3 types. Type I was defined as with peripheral ossification,...

The molecular mechanisms underlying the development of osteosarcoma (OS) are not fully understood. In this study, we investigated for first time clinical significance and biological activity centrosomal protein 55 (CEP55) in OS. We found that CEP55 was overexpressed OS, expression level OS correlated with metastasis poor prognosis. Through vitro experiments, confirmed knockdown significantly induced cell cycle arrest at G1 phase suppressed proliferation, migration invasion. addition, tumour...

Background: A discoid lateral meniscus in the knee is more common Asian populations. The aim of this study was to evaluate influence arthroscopic meniscectomy on axial alignment lower limb adolescents (younger than twenty years age). Methods: We retrospectively reviewed data from 298 adolescent patients age) who underwent treatment our center 2004 2013. Patients were divided into three groups according type: torn (Group A), nondiscoid B), and without a tear C). tibiofemoral angle (TFA)...

Cement spacers (Masquelet technique) have traditionally been used for the treatment of segmental bone defects. However, no reports cement small/partial defects associated with osteomyelitis and compared outcomes beads. We retrospectively analysed 40 patients post-traumatic tibia who underwent treatment, which was performed in two stages. In first stage, thorough debridement performed, were filled either antibiotic-impregnated beads (bead group, 18 patients) or (spacer 22 patients). second...

Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with development human cancer including colorectal and hepatocellular cancer. This study aimed to investigate role osteosarcoma (OS).132 OS patients 1270 healthy controls were recruited for genotyping analysis rs145204276. Promoter methylation level determined all patients. The tumor tissues adjacent normal tissue collected from 42 during surgery relative expression then quantified by...

Objectives To evaluate the long‐term efficacy of cannulated internal fixation in patients who sustain femoral neck fracture (FNF) and risk factors influencing outcomes. Methods This retrospective study analyzed data from 73 elderly aged ≥60 years old, hospitalized for FNF treated with between August 2008 July 2016. The inclusion criteria were: (i) years; (ii) recent fracture, times injury ranging 12–72 h; (iii) underwent Garden II–IV closed reduction fixation. Patients were classified based...

Objective Treatment of distal femoral fracture in post‐polio patients is difficult because the bone usually osteopenic, small and deformed. This retrospective study aimed to investigate outcomes treated by locking compression plates ( LCP ). Methods The medical records 19 (mean age 49 years at time surgery) were reviewed intraoperative data retrieved. Fracture union callus formation evaluated on radiographs taken each postoperative visit. Functional outcome assessments included range motion...

Objective To determine the clinical outcome and complications associated with use of free vascularized fibular graft (FVFG) in resection reconstruction extremity osteosarcoma (OS). Methods This is a retrospective study recruiting consecutive series 18 patients who had undergone OS between May 2009 June 2017 our clinic center. Reconstruction bone defect FVFG was performed for each patient. Surgery‐related time union were recorded at follow‐up visit. The functional reconstructed limb assessed...

Previous studies have demonstrated that endogenous parathyroid hormone-related peptide (PTHrP) plays a central role in the physiological regulation of bone formation. However, it is unclear whether PTHrP an important function enhancing fracture healing. To determine haploinsufficiency impaired healing, closed mid-diaphyseal femur fractures were created 8-week-old wild-type and Pthrp(+/-) mice. Callus tissue properties analysed 1, 2 4 weeks after by radiography, histology, histochemistry,...

GIT1, a scaffold protein with ubiquitous multi-domain, is involved in many cellular processes. In recent years, it was proved that GIT1 participated various tumors' growth or metastasis. However, the biological function of osteosarcoma still unclear. this study, we aimed to investigate role and mechanism osteosarcoma.Human tissues were obtained distribution GIT1. Adequate cells stably infected lentivirus knockdown level then used carry out cell invasion vascular endothelial factor (VEGF)...

Previous pharmacogenetics studies showed that genetic variants could be indicative of the response to chemotherapy. We aimed investigate whether FasL, MSH2, ABCC5, CASP3 and CYP3A4 are associated with outcome after chemotherapy-based treatment in osteosarcoma. 132 osteosarcoma patients who had completed neoadjuvant chemotherapy our center were included. 5-year progression-free survival (PFS) was assessed from initial earliest sign disease progression or death any cause. 5 SNPs genotyped...

To study the effects of ulnar styloid and sigmoid notch fractures on postoperative wrist function in patients with distal radius fracture.