A5082077159- Retinal Diseases and Treatments
- Estrogen and related hormone effects
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Prostate Cancer Treatment and Research
- Cardiovascular and exercise physiology
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ocular Diseases and Behçet’s Syndrome
- Heart Rate Variability and Autonomic Control
- Glaucoma and retinal disorders
- Genomics and Chromatin Dynamics
- Hedgehog Signaling Pathway Studies
- Plant Stress Responses and Tolerance
- Retinoids in leukemia and cellular processes
- Radiopharmaceutical Chemistry and Applications
- Antioxidant Activity and Oxidative Stress
- High Altitude and Hypoxia
- Genetics and Neurodevelopmental Disorders
- Hormonal Regulation and Hypertension
- Nuclear Receptors and Signaling
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Rice Cultivation and Yield Improvement
Zhuhai People's Hospital
2025
Capital Medical University
2012-2024
Beijing Tongren Hospital
2012-2024
Chengdu Medical College
2023-2024
First Affiliated Hospital of Chengdu Medical College
2024
Mallinckrodt (United States)
2023
Peking University People's Hospital
2023
Peking University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Zhongshan Hospital
2023
The physiological and pathological manifestations of Sonic hedgehog (Shh) signaling arise from the specification unique transcriptional programs dependent upon key nuclear effectors Ci/Gli family transcription factors. However, underlying mechanism by which Gli proteins regulate target gene in nucleus remains poorly understood. Here, we identify characterize a physical functional interaction between Gli3 MED12 subunit within RNA polymerase II Mediator. We show that binds to intact Mediator...
Significance TATA-binding protein (TBP)-associated factor 7l ( Taf7l ), Taf4b , and TBP-related 2 Trf2 ) were found to be three important atypical testis-specific core promoter recognition factors. However, whether there was any functional cross-talk between them at which stages of spermatogenesis remained uncharacterized. Here we report that − /Y becomes sterile rather than merely subfertile after backcrossing. Importantly, cooperates with but not late direct the transcription key...
Noninvasive, continuous measurements in vivo are commonly used to make inferences about mechanisms controlling internal and external respiration during exercise. In particular, the dynamic response of muscle oxygenation (Sm(O(2))) measured by near-infrared spectroscopy (NIRS) is assumed be correlated that venous oxygen saturation (Sv(O(2))) invasively. However, there situations where dynamics Sm(O(2)) Sv(O(2)) do not follow same pattern. A quantitative analysis exercise necessary explain...
Recurrent missense mutations in the RNA polymerase II Mediator subunit MED12 are associated with X-linked intellectual disability (XLID) and multiple congenital anomalies, including craniofacial, musculoskeletal, behavioral defects humans FG (or Opitz-Kaveggia) Lujan syndromes. However, molecular mechanism(s) underlying these phenotypes is poorly understood. Here we report that R961W N1007S causing syndromes, respectively, disrupt a Mediator-imposed constraint on GLI3-dependent Sonic...
A randomized clinical trial is needed to evaluate what the best photodynamic therapy (PDT) protocol use for acute central serous chorioretinopathy.To compare efficacy and safety of a 50% dose verteporfin (a method PDT) with 30% chorioretinopathy.A multicenter, noninferiority, double-masked, randomized, controlled, in which 131 patients (131 eyes) chorioretinopathy less than 6 months were recruited follow-up 12 from university-based ophthalmology practices.Patients randomly assigned either...
Purpose: To assess the efficacy and safety of intravitreal conbercept injections in patients with macular edema secondary to retinal vein occlusion (RVO). Methods: A prospective, Phase II clinical trial was performed on 60 RVO. Thirty had branch RVO (BRVO) 30 central (CRVO). Each patient received monthly up 3 months, followed by evaluation injection pro re nata Month 9. Results: The average change best-corrected visual acuity from baseline 9 17.83 ± 10.89 letters BRVO 14.23 11.74 CRVO. not...
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue TFIID subunit TAF7, is enriched in adipocytes white fat (WAT) mouse. Depletion TAF7L reduced adipocyte-specific gene expression, compromised adipocyte differentiation, WAT as well. Ectopic expression myoblasts reprograms these muscle precursors into upon induction. Genome-wide mRNA-seq profiling ChIP-seq binding...
Semaphorin-3A is a chemorepellent guidance protein that crucial in regulating the tumor microenvironment. MMP-14, membrane-anchored matrix metalloproteinase, closely associated with extracellular (ECM) remodeling and cell migration progression of cancer metastasis. In present study, correlation between expression levels semaphorin-3A their subsequent prognostic significance non-small lung (NSCLC), was investigated. The MMP-14 analyzed 94 cases NSCLC tissues 80 normal tissues, using...
Coumarins are plant-derived natural products with a broad range of known pharmacological activities including anticancer effects. However, the molecular mechanisms by which this class promising compounds exerts their effects remain largely unknown. We report here that furanocoumarin named apaensin could effectively induce apoptosis cancer cells through its activation Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAPK). Apoptosis induction in was suppressed chemical...
Abstract Background This study aimed to investigate the mechanism of miR-29a-3p in regulating endometrial cancer (EC) progression. Methods A total 72 EC patients were enrolled. cells transfected. Cells proliferation, cloning ability, migration and invasion researched by MTT assay, colony formation experiment, cell scratch test Transwell experiment respectively. Dual-luciferase reporter assay was performed. Xenograft conducted using nude mice. miR-29a-3p, VEGFA, CDC42, PAK1 p-PAK1 expression...
This letter provides a review of the report by Peng et al on unique case non-small cell lung cancer (NSCLC), specifically adenocarcinoma, featuring reactive oxygen species proto-oncogene 1-receptor (ROS1) co-mutation. The involves 64-year-old patient who exhibited both epidermal growth factor receptor (EGFR) L858R mutation and ROS1 rearrangement, achieving significant disease stabilization following treatment with crizotinib. rare EGFR/ROS1 co-mutation poses distinct challenges for clinical...
Retinoid X receptor (RXR) plays a crucial role in the cross talk between retinoid receptors and other hormone including orphan TR3, forming different heterodimers that transduce diverse steroid/thyroid signaling. Here we show RXRα exhibits nucleocytoplasmic shuttling MGC80-3 gastric cancer cells is energy-dependent through nuclear pore complex (NPC)-mediated pathway for its import an intact DNA binding domain-mediated export. In presence of ligand 9-cis retinoic acid, was almost exclusively...
It has been hypothesized that the macular carotenoids protect against age-related degeneration (AMD). In this study, association between serum concentrations of and presence AMD was evaluated in a case-control sample elderly Chinese subjects.Two hundred sixty-three individuals aged 50 88 years enrolled study. Subjects included 82 cases with exudative AMD, 92 early 89 control individuals. Serum (lutein, zeaxanthin, lycopene, α- β-carotenes, β-cryptoxanthin) retinol were measured...
Purpose: Macular pigment may protect against age-related macular degeneration (AMD) by its capacity to absorb blue light and scavenge free radicals. Current information on human density has been largely from studies Caucasian populations. The purpose of this study was assess determinant factors in a Chinese population sample. Methods: optical (MPOD) measured healthy using heterochromatic flicker photometry (HFP). Participants received standard ophthalmic examination, only subjects who were...
Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding associated factor 7L (TAF7L) is important regulator of white (WAT) differentiation. In this study, show TAF7L also serves as a molecular switch between brown fat and muscle lineages vivo vitro. tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping distal enhancers...
Wheat (Triticum aestivum L.) is one of the three major global food crops. High-temperature stress can affect its yield and quality. Studies effect high-temperature on wheat kernel development are important because they reveal stability quality lead to genetic improvement traits. In this study, isobaric tags for relative absolute quantitation (iTRAQ) method was adopted analyze changes in protein expression profile cultivars under high temperature stress. The content grain increased heat...
The glucocorticoid receptor (GR) has been linked to therapy resistance across a wide range of cancer types. Preclinical data suggest that antagonists this nuclear may enhance the activity anticancer therapy. first-generation GR antagonist mifepristone is currently undergoing clinical evaluation in various oncology settings. Structure-based modification led discovery ORIC-101 (28), highly potent steroidal with reduced androgen (AR) agonistic amenable for dosing positive tumors and improved...
The protective antigen (PA) component of the anthrax toxin forms pores within low pH environment host endosomes through mechanisms that are poorly understood. It has been proposed pore formation is dependent on histidine protonation. In previous work, we biosynthetically incorporated 2-fluorohistidine (2-FHis), an isosteric analogue with a significantly reduced pK(a) ( approximately 1), into PA and showed pH-dependent conversion from soluble prepore to was unchanged. However, also observed...
To investigate whether the previously reported noncoding variant of complement factor H (CFH) gene and two coding variants component 3 (C3) are associated with exudative age-related macular degeneration (AMD) in Chinese patients.One hundred fifty patients AMD 161 control individuals without were recruited for study. Genomic DNA was extracted from blood leukocytes. The CFH (rs1410996) C3 (rs2230199 rs1047286) genotyped by polymerase chain reaction (PCR) followed allele-specific restriction...