A5100611572- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Connective tissue disorders research
- Pelvic and Acetabular Injuries
- Aortic Disease and Treatment Approaches
- Parasitic infections in humans and animals
- Cardiac and Coronary Surgery Techniques
- Congenital Anomalies and Fetal Surgery
- Amoebic Infections and Treatments
- Medical Imaging and Analysis
- Aortic aneurysm repair treatments
- Bone Tumor Diagnosis and Treatments
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cardiac Valve Diseases and Treatments
- Glaucoma and retinal disorders
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Growth Hormone and Insulin-like Growth Factors
- Surgical Sutures and Adhesives
- Protein Tyrosine Phosphatases
- Osteoarthritis Treatment and Mechanisms
Nanjing Drum Tower Hospital
2014-2023
Weatherford College
2023
Nanjing Medical University
2015-2020
Chinese University of Hong Kong
2015-2019
The People's Hospital of LinXia
2016
First Affiliated Hospital of Hebei Medical University
2016
Hebei Medical University
2016
National Natural Science Foundation of China
2015
Nanjing University
2014-2015
Nanjing Children's Hospital
2015
Abstract Adolescent idiopathic scoliosis (AIS) is a structural deformity of the spine affecting millions children. As complex disease, genetic aetiology AIS remains obscure. Here we report results four-stage genome-wide association study (GWAS) conducted in sample 4,317 patients and 6,016 controls. Overall, identify three new susceptibility loci at 1p36.32 near AJAP1 (rs241215, P combined =2.95 × 10 −9 ), 2q36.1 between PAX3 EPHA4 (rs13398147, =7.59 −13 ) 18q21.33 BCL-2 (rs4940576, =2.22 −12...
The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result a 4-stage genome-wide association study composed 5,953 AIS patients and 8,137 controls. Overall, identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (Pcombined = 1.19 × 10−13, OR 1.21, 95% CI 1.10–1.32), rs7633294 3p14.1 MAGI1 1.85 10−12, 1.20, 1.09–1.32), rs9810566 3q26.2 TNIK 1.14 10−11, 1.19, 1.08-1.32). We also confirmed recently reported...
Sinus of Valsalva aneurysm is a rare anomaly. This study was designed to assess the long-term outcome surgical repair sinus and factors influencing prognosis. From August 1980 repair. Ventricular septal defect (42) aortic regurgitation (34) were most frequent coexisting anomalies. An approach via involved chamber used in 60 patients, aortotomy 5, combined 35. Either direct (43) or patch (57) closure defect. Aortic valve replacement required 14 8 needed valvuloplasty. Eighty patients followed...
A comparison between the smartphone-aided measurement method and manual for Cobb angle in adolescent idiopathic scoliosis.To evaluate reliability error compare its with those of method.The development smartphones has provided new opportunities that integrate mobile technology into daily clinical practice. Smartphone applications can provide quick assistance diagnosis treatment disease. Cobbmeter is a smartphone application designed on Apple iPhone smartphones. There no study this method.:...
A retrospective radiographical study.To compare the prediction abilities of T1 pelvic angle (TPA) and other parameters for postoperative sagittal balance, investigate relationships between these health-related quality life.Using vertical axis (SVA) to assess alignment fails take account compensation. new parameter, TPA, has been recommended represent global balance adult scoliosis.A review was performed on patients with scoliosis undergoing correction surgery from May 2009 March 2013. The...
A prospective, cross-sectional study.To determine the independent variables associated with lumbar lordosis (LL) and to establish predictive formula of ideal LL in Chinese population.Several formulas have been established Caucasians estimate be restored for fusion surgery. However, there is still a lack knowledge concerning establishment such population.A total 296 asymptomatic adults were prospectively recruited. The relationships between including pelvic incidence (PI), age, sex, body mass...
Study Design: A retrospective study. Objective: To assess the accuracy and safety of placement pedicle screws (PSs) on pediatric patients with congenital scoliosis younger than 10 years through postoperative computed tomography scanning. Summary Background Data: The PSs in adolescent adult population various spinal problems has been thoroughly studied. As to scoliosis, related studies were inadequate. Methods: review was carried out 96 years, who received posterior instrumentation from...
To explore the effect of right dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) on memory, and its correlation with levels hippocampal brain metabolites detected by proton resonance spectroscopy (1H-MRS) in recently detoxified alcohol-dependent patients.In this randomized, double-blind sham-controlled trial, patients were enrolled randomized into two groups: experimental group (rTMS, 10 Hz, DLPFC, 20 sessions) control (sham stimulation). Memory...
Scoliogauge, has been developed for the measurement of ATR on iPhone smartphones. This study was to evaluate reliability smartphone-aided method and compare its with that manual method. Sixty-four AIS patients single thoracic or lumbar curve participated in this study. Of these patients, thirty-two had main scoliosis while other thoracolumbar/lumbar scoliosis. Two spine surgeons performed measurements Scoliometer Scoliogauge. The Scoliogauge were conducted an 4 smartphone. intraclass...
Cardiac cystic echinococcosis (CE), or hydatid cyst is exceptionally uncommon. We review the experience of surgical treatment cardiac CE.Twenty-six patients (11 females; mean age, 28.9 ± 7.6 years) with CE undergoing from February 1978 to April 2013 were reviewed. The operative methods mainly included puncture-aspiration cystectomy, intact endocyst enucleation and total resection.Cardiac was located in myocardium 16 cases, pericardium 8 both 2. There 21 cases solitary including at left...
An association study to comprehensively clarify variations of genetic determinants peak height velocity (PHV) during puberty in adolescent idiopathic scoliosis (AIS).To investigate whether the timing and magnitude PHV are associated with susceptibility or curve progression female patients AIS.An involvement abnormal pubertal growth pattern etiopathogenesis AIS has been implicated previous studies. However, there is no clear consensus on anthropometric stature rate. The recent advance...
A case-only study.The aim of this study was to evaluate the association 53 single-nucleotide polymorphisms (SNPs) in a prognostic test with curve progression Chinese adolescent idiopathic scoliosis (AIS) patients."ScoliScore" first diagnostic kit developed for AIS white population. To date, there is still paucity validation ScoliScore Han population.A total 670 patients were included study, 313 assigned nonprogression group and other 357 group. panel SNPs encompassed genotyped using...
Between 1978 and 2002, 15 patients (mean age, 23.0 +/- 8.5 years) with cardiac pericardial echinococcosis were treated surgically. The cysts located in the right atrium 3 patients, on anterior myocardium 7, pericardially 5. atrial operated using cardiopulmonary bypass. There 4 recurrences requiring re-operation after a mean of 12 months. All other received mebendazole treatment exhibited no recurrence during follow-up. One late death due to chronic heart failure occurred 10 months serologic...
Study Design: A retrospective study to determine whether brace treatment is appropriate for adolescent idiopathic scoliosis patients with Cobb angle between 40 and 50 degrees who utterly refuse surgery. Objective: To investigate it possible halt the curve progression of through bracing, identify factors that could influence effectiveness in such patients. Summary Background Data: Despite great achievements treating mild curve, bracing has been considered be inappropriate those curves >40...
A genetic association study of 53 single nucleotide polymorphisms (SNPs) with adolescent idiopathic scoliosis (AIS).To explore new predisposition genes AIS in Chinese Han population SUMMARY OF BACKGROUND DATA.: panel SNPs were reported to be associated curve severity AIS. However, there is still a lack knowledge concerning the these susceptibility population.A gene-based was conducted by genotyping prognostic test. DNA samples 990 female patients and 1188 age-matched healthy controls...
A retrospective radiographic study.To investigate the reliability of using magnetic resonance imaging (MRI) to measure thoracic outlet parameters and whether supine MRI could supersede upright x-ray in measuring these parameters.On x-ray, overlapped soft bony tissues make sternum contour invisible. Thus, inlet (TI) alignment on may be inaccurate. clearly show anatomy around TI.A total 124 adolescents with idiopathic thoracolumbar/lumbar scoliosis were recruited. The visibility T1 upper...
Abstract It is well-documented that melatonin deficiency has been linked to the etiopathogenesis of adolescent idiopathic scoliosis. In this study, we intended apply in melatonin-deficient mice ascertain whether could reduce incidence/severity scoliosis, and investigate role on bone mineral density A total 80 were divided into 4 groups: 20 quadrupedal bipedal served as controls; received oral (8 mg/kg BW) daily. After 5 th , 10 15 weeks treatment, radiographs vivo micro-CT used determine...