A5022033472- Scoliosis diagnosis and treatment
- Endometriosis Research and Treatment
- Spinal Fractures and Fixation Techniques
- Reproductive System and Pregnancy
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Spine and Intervertebral Disc Pathology
- Sports injuries and prevention
- Immune cells in cancer
- Tea Polyphenols and Effects
- Lower Extremity Biomechanics and Pathologies
- Uterine Myomas and Treatments
- Osteoarthritis Treatment and Mechanisms
- Phagocytosis and Immune Regulation
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Circadian rhythm and melatonin
- Tannin, Tannase and Anticancer Activities
- Vitamin D Research Studies
- Myofascial pain diagnosis and treatment
- Bone and Joint Diseases
- Cancer Mechanisms and Therapy
- Hip disorders and treatments
- Phytochemicals and Antioxidant Activities
- Angiogenesis and VEGF in Cancer
Chinese University of Hong Kong
2015-2024
Prince of Wales Hospital
2014-2024
Nanjing University
2017-2022
Shatin Hospital
2022
Hospital Authority
2014
Shenzhen Institutes of Advanced Technology
2010
Shenzhen Second People's Hospital
2010
Emerging evidence shows that the efficacy of chemotherapeutic drugs is reliant on their capability to induce immunogenic cell death (ICD), thus transforming dying tumor cells into antitumor vaccines. We wanted uncover potential therapeutic strategies target ovarian cancer by having a better understanding standard-of-care chemotherapy treatment. Here, we showed in paclitaxel induced ICD-associated damage-associated molecular patterns (DAMP, such as CALR exposure, ATP secretion, and HMGB1...
Mesenchymal stem cells (MSCs) hold promising translational potential in cartilage regeneration. However, the efficacy of MSC-based tissue engineering is not satisfactory treatment defect because inevitable cellular functional changes during ex vivo cell expansion. How to maintain chondrogenic capacity MSCs improve their therapeutic outcomes remains an outstanding question.Bone marrow-derived were firstly primed induction medium which was then replaced with normal growth attain manipulated...
Abstract Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous group myeloid with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood patients endometriosis peritoneal cavity mouse model surgically induced endometriosis. Majority were granulocytic, produced ROS, arginase, suppressed T‐cell proliferation. Depletion by antiGr‐1...
Study Design. A cross-sectional radiographic study. Objective. The aim of this study was to establish the age- and sex-related normative values whole-body sagittal alignment in asymptomatic Chinese adult population, investigate changes possible associated compensation mechanisms across age groups. Summary Background Data. Previous studies have reported data for spinal adults. However, there a lack comprehensive investigation on alignment. Methods. total 584 adults aged 20 89 years were...
Loosening is the leading cause of total knee arthroplasty (TKA) revision. This a heavy burden toward healthcare system owing to difficulty in diagnosis and complications occurring from delay management. Based on automatic analytical model building, machine learning, may potentially help automatically recognize risk loosening based radiographs alone. The aim this study was build an image-based machine-learning for detecting TKA loosening. Image-based developed ImageNet, Xception patient X-ray...
Melatonin signaling dysfunction has been associated with the etiology of adolescent idiopathic scoliosis (AIS). Genetic analysis also occurrence AIS MT2 gene. Thus, we determined whether there is abnormality in protein expression melatonin receptors (MT) osteoblasts. In this study, recruited 11 girls severe and eight normal subjects for intraoperative bone biopsies. MT1 receptor expressions isolated osteoblasts were detected. Also, cell proliferation assay using different concentrations (0,...
Abstract Background Previous studies have shown a major green tea polyphenol (−)-epigallocatechin-3-gallate ((−)-EGCG) as powerful anti-cancer agent. However, its poor bioavailability and requirement of high dosage to manifest activity restricted clinical application. Recently, our team synthesized peracetate-protected derivative EGCG, which can act prodrug (−)-EGCG (ProEGCG) with enhanced stability improved in vitro vivo. Herein, we tested the therapeutic efficacy this novel ProEGCG,...
In Brief Study Design. Magnetic resonance (MR) imaging and multiplanar reconstruction was used to evaluate the morphology relative position of spinal cord in adolescent idiopathic scoliosis (AIS). Objective. To determine longitudinal cross-sectional AIS subjects versus normal controls their correlation with cerebellar tonsils somatosensory cortical evoked potentials (SSEP). Summary Background Data. Our previous studies revealed significantly reduced vertebral column length ratios patients...
Abstract Purpose To investigate whether regional brain volumes in adolescent idiopathic scoliosis (AIS) patients differ from matched control subjects as AIS are reported to have poor performance on combined visual and proprioceptive testing impaired postural balance previous studies. Materials Methods Twenty female with typical right‐convex thoracic curve (age range,11–18 years; mean, 14.1 years) 26 controls (mean age, 14.8 underwent three‐dimensional magnetization prepared rapid acquisition...
Abnormalities in the melatonin signaling pathway and involvement of receptor MT2 have been reported patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved systemic abnormal skeletal growth AIS during peripubertal period remain unknown. In this cross-sectional case-control study, plate chondrocytes (GPCs) cultured from twenty ten normal control subjects. Although was identified GPCs both controls, its mRNA expression significantly lower than controls....
This prospective cohort study was designed to evaluate the survivorship and functional outcomes associated with long-term results of medial open-wedge high tibial osteotomy (MOWHTO) for treatment compartment knee osteoarthritis in Chinese population. Although MOWHTO is a well-established procedure management knee, outcome population has not been reported current literature. We hypothesised that would result preservation function Chinese, similar Caucasian population.A 22 young adult patients...
This study investigated the accuracy in achieving proper lower limb alignment and component positions after total knee replacement (TKR) with image-free image-based robotic-assisted TKR.A of 129 patients (166 knees) suffering from end-stage arthritis who underwent TKA operated by surgery between years 2018 mid-2021 were recruited. Radiological outcomes compared surgical systems.There significant differences two robotic systems when comparing mean planned measured on radiographs, which system...
In Brief Study Design. Conventional and phase-contrast magnetic resonance (MR) imaging were used to evaluate the morphology cerebrospinal fluid (CSF) flow dynamics at craniocervical junction in adolescent idiopathic scoliosis (AIS). Objectives. To determine of cerebellar tonsil, foramen magnum, dynamic CSF AIS patients versus normal controls their correlation with somatosensory cortical evoked potentials (SSEP). Summary Background Data. Previous studies have documented obstructed Chiari I...