A5101773345- Periodontal Regeneration and Treatments
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Tracheal and airway disorders
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Trauma Management and Diagnosis
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
- Uterine Myomas and Treatments
- Animal Genetics and Reproduction
- Silk-based biomaterials and applications
- Dental Implant Techniques and Outcomes
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Intestinal and Peritoneal Adhesions
- Oral microbiology and periodontitis research
- CRISPR and Genetic Engineering
- Total Knee Arthroplasty Outcomes
Chinese Academy of Sciences
2024-2025
Shenzhen Institutes of Advanced Technology
2024-2025
Guangdong Pharmaceutical University
2025
Shanghai Children's Medical Center
2024
Shanghai Jiao Tong University
2011-2024
West China Hospital of Sichuan University
2023-2024
Sichuan University
2023-2024
Hainan General Hospital
2023
Army Medical University
2010-2022
Southwest Medical University
2022
Precise genetic mutation of model animals is highly valuable for functional investigation human mutations. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9)-induced homology-directed repair (HDR) usually used precise mutation, being limited by the relatively low efficiency compared with that non-homologous end joining (NHEJ). Although inhibition NHEJ was shown to enhance HDR-derived in this work, without NHEJ, we first generated gene-modified pigs...
Abstract Inflammation resolution is an active process, the failure of which causes uncontrolled inflammation underlies many chronic diseases. Therefore, endogenous pathways that regulate are fundamental and wide interest. Here, we demonstrate phagocyte respiratory burst-induced hypoxia activates macrophage erythropoietin signalling to promote acute resolution. This activated following but not inflammation. Pharmacological or genetical inhibition burst suppresses signalling....
Abstract We have previously observed that knockout of Niemann-Pick C1-Like 1 (NPC1L1), a cholesterol transporter essential for intestinal absorption, reduces the output dry stool in mice. As food intake remains unaltered NPC1L1-knockout (L1-KO) mice, we hypothesized NPC1L1 deficiency may alter gut microbiome to reduce output. Consistently, here demonstrate phyla fecal microbiota differ substantially between L1-KO mice and their wild-type controls. Germ-free (GF) reduced Inhibition by its...
Acellular cartilage sheets (ACSs) have been demonstrated as a good biomaterial for regeneration result of their natural matrix components, cartilage-specific structures, and biocompatibility. However, it remains unknown whether allogeneic ACSs could promote repair defects in large animal model. The current study explored the feasibility repairing articular using ACS scaffold with or without autologous bone marrow stromal cells (BMSCs) swine According to results, retained structure, primary...
Abstract Background Intracranial germ cell tumors (IGCTs) are a rare group of malignancies that clinically classified as germinomas and nongerminomatous (NGGCTs). Previous studies have found somatic mutations involving the mitogen-activated protein kinase/mTOR signaling pathway common early events. However, comprehensive genomic understanding IGCTs is still lacking. Methods We established cohort including over 100 conducted transcriptomic sequencing. Results identified novel recurrent driver...
Background Schizophyllan (SPG), a bioactive polysaccharide from Schizophyllum commune , possesses significant anti-inflammatory, antioxidant, and immunomodulatory properties. The molecular weight of polysaccharides significantly impacts their structural properties biological functions. However, the functional characteristics low derived remain inadequately explored. Methods This study developed an ultrasound-assisted hydrogen peroxide (H 2 O ) degradation method to produce...
Functional reconstruction of large cartilage defects in subcutaneous sites remains clinically challenging because limited donor cartilage. Tissue engineering is a promising and widely accepted strategy for regeneration. To date, however, this has not achieved significant breakthrough clinical translation owing to lack detailed preclinical data on cell yield functionality applicable chondrocytes. address issue, the current study investigated initial yield, proliferative potential,...
An acellular matrix (AM) as a kind of natural biomaterial is gaining increasing attention in tissue engineering applications. cartilaginous (ACM) and dermal (ADM) are two kinds the most widely used AMs cartilage engineering. However, there still debate over which these achieves optimal regeneration, especially immunocompetent large animals. In current study, we fabricated porous ADM ACM scaffolds by freeze-drying method confirmed that had larger pore size than ACM. By recolonization with...
The efficient removal of apoptotic cells (ACs), a process termed as efferocytosis, is essential for immune homeostasis. While recent work has established an important interplay between efferocytosis and cellular metabolic changing, underlying mechanisms remain poorly known. Here, we discovered that pentose phosphate pathway (PPP) regulates tolerogenic ACs clearance tolerance. decreased levels PPP-related genes metabolites in macrophages. AG1, the agonist PPP, increased activity PPP but...
The traditional Chinese medicine Gastrodia elata (commonly called "Tianma" in Chinese) has been widely used the treatment of rheumatism, epilepsy, paralysis, headache, and dizziness. Phenolic compounds, such as gastrodin, para-hydroxybenzyl alcohol (HBA), p-hydroxybenzaldehyde, vanillin are main bioactive components isolated from elata. These compounds not only structurally related but also share similar pharmacological activities, antioxidative anti-inflammatory effects on aging-related...
Patches for hernia repair have two existing concerns: antibacterial and tissue adhesion.
Abstract Photodynamically induced cell immunogenic death has emerged as an effective antitumor strategy because of its capacity to stimulate anti‐tumor immunity for eliminating primary tumors and metastases. Considering that the short‐lived reactive oxygen species (ROS) anoxic tumor microenvironment restrict efficacy conventional photodynamic therapy (PDT), a molecular framework near‐infrared (NIR) type I aggregation‐induced emission (AIE) photosensitivities with tunable sub‐organelles...