A5101448566- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Osteoarthritis Treatment and Mechanisms
- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
Chinese University of Hong Kong
2009-2025
Sinopec (China)
2025
SINOPEC Research Institute of Safety Engineering Co., Ltd.
2025
University of Glasgow
2024
Institute of Chemical Industry of Forest Products
2015-2024
Huazhong Agricultural University
2017-2024
Jiangsu Academy of Agricultural Sciences
2024
Fudan University
2024
Liaocheng People's Hospital
2024
Chinese Academy of Forestry
2024
The forkhead family protein FOXP3 acts as a repressor of transcription and is both an essential sufficient regulator the development function regulatory T cells. molecular mechanism by which FOXP3-mediated transcriptional repression occurs remains unclear. Here, we report that involves histone acetyltransferase-deacetylase complex includes acetyltransferase TIP60 (Tat-interactive protein, 60 kDa) class II deacetylases HDAC7 HDAC9. N-terminal 106-190 aa are required for TIP60-FOXP3,...
Lignin is the most abundant aromatic source of natural products, but developing efficient catalysts to depolymerize it into valuable monophenol with high yield and unique selectivity remains a challenge. Herein, we report Ru single-atom catalyst (SAC) supported on rod CeO2 oxygen vacancies (Ov) for depolymerization birch dioxane acidolysis lignin (DAL). A near-theoretical maximum (14.8 wt %) good 4-n-propenyl guaiacol (51.4%), as well stability, was achieved. The calculated turnover (TON)...
Cholesterol 25-hydroxylase (CH25H) has recently been identified as a host restriction factor that exerts antiviral effects by catalyzing the production of 25-hydroxycholesterol (25HC). CH25H can be rapidly induced upon infection with some viruses. Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, ranked among most important swine pathogens since it was discovered in late 1980s. In this study, we found PRRSV significantly downregulated expression cells so-far...
In the previous study, we established a mouse model of cardiac hypertrophy using transverse aortic constriction (TAC) and found that expression long non-coding RNAs TINCR was downregulated in myocardial tissue. The present study designed to determine potential role pathogenesis hypertrophy. Our results showed enforced could attenuate TAC mice. Angiotensin II (Ang-II) be associated with reduced increased cultured neonatal cardiomyocytes. RNA-binding protein immunoprecipitation assay confirmed...
Background With the development of high-throughput screening, a variety genetic alterations has been found in hepatocellular carcinoma (HCC). Although previous studies on HCC methylation profiles have focused liver tissue, using isolated hepatocytes are rare. The heterogeneity composition may impact genuine status HCC; therefore, it is important to clarify profile aid understanding process tumorigenesis. Methods and Findings global single from tissue hepatitis B virus (HBV) related (HBHC)...
Ten-Eleven Translocation 1 (TET1) is a member of ten eleven translocation enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). TET1 can promote CpG islands demethylation in specific genes and often absent various cancers. Herein, we found that expression 5-hmC content were low gastric tumors compared its adjacent non-tumor tissues. Cell proliferation, migration invasion enhanced upon knockdown cancer cells vitro. This phenomenon was confirmed by an animal...
Triple-negative breast cancer (TNBC) cells lack the expression of ER, PR and HER2. Thus, TNBC patients cannot benefit from hormone receptor-targeted therapy as non-TNBC patients, but can only receive chemotherapy systemic treatment have a worse overall outcome. More effective therapeutic targets combination strategies are urgently needed to improve effectiveness. Methods: We analyzed levels EZH2 TET1 in TCGA our own patient cohort, tested their correlation with survival. used cell lines...
Hepatocellular carcinoma (HCC) is a common solid tumor worldwide with poor prognosis. Accumulating evidence has implicated important regulatory roles of epigenetic modifications in the occurrence and progression HCC. In present study, we analyzed 5-methylcytosine (5-mC) 5-hydroxymethylcytosine (5-hmC) levels tissues paired adjacent peritumor (APTs) from four individual HCC patients using (hydroxy)methylated DNA immunoprecipitation approach combined deep sequencing [(h)MeDIP-Seq]....
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen that has devastated the worldwide swine industry for over 30 years. Autophagy evolutionarily conserved intracellular lysosomal degradation pathway, previous studies have documented PRRSV infection prompts autophagosome accumulation. However, whether induces complete or incomplete autophagy remains controversial. Here, we demonstrated overexpression of nonstructural protein 5 (nsp5) induced...
It has been established that mammalian target of Rapamycin (mTOR) inhibitors have anti-inflammatory effects in models experimental colitis. However, the underlying mechanism is largely unknown. In this research, we investigate AZD8055, a potent mTOR inhibitor, on T cell response dextran sulfate sodium (DSS)-induced colitis mice, commonly used animal model inflammatory bowel diseases (IBD). Severity evaluated by changing body weight, bloody stool, fecal consistency, histology evaluation and...
Protein-protein interaction (PPI) network maintains proper function of all organisms. Simple high-throughput technologies are desperately needed to delineate the landscape PPI networks. While recent state-of-the-art yeast two-hybrid (Y2H) systems improved screening efficiency, either individual colony isolation, library preparation arrays, gene barcoding or massive sequencing still required. Here, we developed a recombination-based 'library vs library' Y2H system (RLL-Y2H), by which...
Abstract In vitro three-dimensional (3D) cartilage regeneration is a promising strategy for repair of defects. However, inferior mechanical strength and tissue homogeneity greatly restricted its clinical translation. Simulation stress through bioreactor an important approach improving in regeneration. The current study developed hydrostatic pressure (HP) based on novel pressure-transmitting mode achieved by slight deformation flexible membrane completely sealed stainless steel device. newly...
Cholangiocarcinoma (CCA), arising from varying locations within the biliary tree, is second most common primary liver malignancy worldwide. Shikonin, an active compound extracted Chinese herb Zicao, holds anti-bacterial, anti-inflammatory, and anti-tumor activities. However, effect of shikonin on human cholangiocarcinoma detailed mechanisms TRAIL enhancement remains to be elucidated. The purpose study was investigate protective functions for induced apoptosis in cells.We use MTT assay,...
Three series of novel urushiol derivatives were designed by introducing a hydroxamic acid moiety into the tail an alkyl side chain and substituents with differing electronic properties or steric bulk onto benzene ring chain. The compounds' binding affinity toward HDAC8 was screened Glide docking. highest-scoring compounds processed further molecular docking, MD simulations, free energy studies to analyze modes mechanisms. Ten had scores −8.2 −10.2, which revealed that hydroxy, carbonyl,...
Fas apoptotic signaling regulates diverse physiological processes. Acute activation of triggers massive apoptosis in liver. Upon receptor stimulation, the BH3-only protein Bid is cleaved into active form, tBid. Subsequent tBid recruitment to mitochondria, which facilitated by its MTCH2 at outer mitochondrial membrane (OMM), a critical step for commitment via effector proteins Bax or Bak. MOAP-1 Bax-binding enriched OMM. Here, we show that MOAP-1-deficient mice are resistant Fas-induced...