A5088248142- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Tracheal and airway disorders
- Respiratory viral infections research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Trauma Management and Diagnosis
- Toxin Mechanisms and Immunotoxins
- Antimicrobial Resistance in Staphylococcus
- Phytase and its Applications
- Streptococcal Infections and Treatments
- Enzyme Production and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Microbial infections and disease research
- Enzyme Catalysis and Immobilization
- Diverse Scientific Research Studies
- Reconstructive Surgery and Microvascular Techniques
- Advanced Drug Delivery Systems
- Tissue Engineering and Regenerative Medicine
- Aquaculture disease management and microbiota
- Peripheral Neuropathies and Disorders
- Transgenic Plants and Applications
- Vascular Anomalies and Treatments
- T-cell and B-cell Immunology
Purdue University West Lafayette
2013-2020
Purdue University Northwest
2020
Annually, swine influenza A virus (SwIAV) causes severe economic loss to industry. Currently used inactivated SwIAV vaccines administered by intramuscular injection provide homologous protection, but limited heterologous protection against constantly evolving field viruses, attributable the induction of inadequate levels mucosal IgA and cellular immune responses in respiratory tract. novel vaccine delivery platform using mucoadhesive chitosan nanoparticles (CNPs) through intranasal (IN)...
Biodegradable nanoparticles with functionalized surfaces are attractive candidates as vaccine adjuvants. Nano-11 cationic dendrimer-like α-D-glucan a diameter of 70-80 nm. Mice injected antigen formulated developed antibody titers that were similar or greater than aluminum adjuvant. Utilizing an in vivo imaging system, was shown to remain at the injection site after administration and cleared gradually over course 3 weeks. Injection induced transient inflammatory response characterized by...
Intranasal vaccination elicits secretory IgA (SIgA) antibodies in the airways, which is required for cross-protection against influenza. To enhance breadth of immunity induced by a killed swine influenza virus antigen (KAg) or conserved T cell and B peptides, we adsorbed antigens together with TLR3 agonist poly(I:C) electrostatically onto cationic alpha-D-glucan nanoparticles (Nano-11) resulting Nano-11-KAg-poly(I:C) Nano-11-peptides-poly(I:C) vaccines. In vitro, increased TNF-α IL-1ß...
Abstract A recombinant vaccine composed of a fusion protein formulated with aluminum hydroxide adjuvant is under development for protection against diseases caused by Streptococcus pyogenes . The safety and local reactogenicity the was assessed comprehensive series clinical, pathologic immunologic tests in preclinical experiments. Outbred mice received three intramuscular injections 1/5th human dose (0.1 ml) rabbits two full dose. Control groups or antigen. did not cause clinical evidence...
The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for transplantation only way to solve this problem. To address these problems, current study proposed series novel strategies. For large-volume cartilage regeneration, sheet technique (without any extra materials) was adopted avoid inflammatory reaction triggered by materials form homogeneous, mature autologous goat model. vascularization, flat...
Abstract Swine influenza A virus (SwIV) causes respiratory tract infection in pigs. Available SwIV vaccines fail to provide cross-protective immunity Nano-11 is an amphiphilic nanoparticle (70–80nm) obtained from sweet corn-derived phytoglycogen. carries high surface positive charge and thus facilitates easy preparation of based vaccine by electrostatic interaction with killed SwIAV antigen (KAg) or peptides (negative charge). Earlier we showed that bound H1N2 Ag (Nano-11+KAg) delivered...