A5100330620- Nutrition and Health in Aging
- Geriatric Care and Nursing Homes
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Frailty in Older Adults
- Renal and Vascular Pathologies
- Metal-Catalyzed Oxygenation Mechanisms
- Pregnancy and Medication Impact
- Intensive Care Unit Cognitive Disorders
- Parathyroid Disorders and Treatments
- Diabetes Treatment and Management
- Physical Activity and Health
- Cerebrovascular and Carotid Artery Diseases
- Pancreatic function and diabetes
- Body Composition Measurement Techniques
- Menopause: Health Impacts and Treatments
- Genetic Syndromes and Imprinting
- Microbial metabolism and enzyme function
- Health and Wellbeing Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Toxicity Studies
- Hormonal and reproductive studies
Johns Hopkins Medicine
2021-2024
Johns Hopkins University
2001-2024
New York University
2023-2024
Central South University
2022
Xiangya Hospital Central South University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Oklahoma Medical Research Foundation
2018
University of Maryland, College Park
2018
Academy of Medical Sciences
2018
Hospital for Special Surgery
2017
Background Pre-liver transplant (LT) sarcopenia is associated with poor survival. Methods exist for measuring body composition use of CT scans; however, it unclear which components best predict post-LT outcomes. Purpose To quantify the association between abdominal CT-based measurements and mortality in a large North American cohort. Materials This was retrospective cohort adult first-time deceased-donor LT recipients from 2009 to 2018 who underwent pre-LT scans, including at L3 vertebral...
Abstract Background Frailty predicts adverse post-kidney transplant (KT) outcomes, yet the impact of frailty assessment on center-level outcomes remains unclear. We sought to test whether centers assessing as part clinical practice have better pre- and post-KT in all adult patients (≥18 years) older (≥65 years). Methods In a survey US (11/2017–4/2018), 132 (response rate = 65.3%) reported their practices (frequency specific tool) at KT evaluation admission. Assessment frequency was...
Background. Kidney transplant (KT) recipients have numerous risk factors for delirium, including those shared with the general surgical population (eg, age and major surgery) transplant-specific neurotoxic immunosuppression medications). Evidence has linked delirium to long-term dementia in older adults undergoing surgery. We sought characterize associated post-KT delirium. Methods. Using United States Renal Data System datasets, we identified 35 800 adult first-time KT ≥55 y. evaluated...
Kidney transplantation (KT) experts did not support the use of subjective unintentional weight loss to measure shrinking in physical frailty phenotype (PFP); a clinically feasible and predictive is needed. To test whether could be replaced by an assessment sarcopenia using existing CT scans, we performed prospective cohort study adult KT recipients with original PFP (oPFP) measured at admission (December 2008–February 2020). We ascertained calculating skeletal muscle index from available,...
The mechanism of O2 reduction by copper amine oxidase from Arthrobacter globiformus (AGAO) is analyzed in relation to the cobalt-substituted protein. enzyme utilizes a tyrosine-derived topaquinone cofactor oxidize primary amines and reduce H2O2. Steady-state kinetics indicate that amine-reduced CuAGAO reoxidized >103 times faster than CoAGAO analogue. Complementary spectroscopic studies reveal difference second order rate constant, kcat/KM(O2), arises more negative redox potential CoIII/II...
The mechanism of ω-6 polyunsaturated fatty acid oxidation by wild-type cyclooxygenase 2 and the Y334F variant, lacking a conserved hydrogen bond to catalytic tyrosyl radical/tyrosine, was examined for first time under physiologically relevant conditions. enzymes show apparent bimolecular rate constants deuterium kinetic isotope effects that increase in proportion co-substrate concentrations before converging limiting values. trends exclude multiple dioxygenase mechanisms as well proposal...
Early post-kidney transplantation (KT) changes in physiology, medications, and health stressors likely impact body mass index (BMI) all-cause graft loss mortality.
Rationale & ObjectiveDue to the high risk of waitlist mortality and post-transplant complications, kidney transplant (KT) patients may benefit from advance care planning (ACP) palliative consultation (PCC). We quantified prevalence racial disparities in ACP PCC among KT candidates recipients.Study DesignProspective cohort studySetting Participants2,575 adult 1,233 recipients (2008-2020).ExposureRace ethnicity.OutcomesAll reports were abstracted chart review. was defined as patient...
Abstract Background Burkholderia cepacia (BC) has been detected more and in infected patients recent years. However, as a high-risk population, the clinical characteristics prognosis of BC infection hematopoietic stem cell transplantation (HSCT) have not reported. The purpose this study is to obtain data that will help fill gaps field, provide evidence for reducing mortality rate HSCT patients, guide use antibiotics future. Methods Electronic medical records with who underwent Xiangya...
Kidney transplant (KT) candidates often experience hospitalizations, increasing their delirium risk. Hospitalizations and are associated with worse post-KT outcomes, yet relationship pre-KT outcomes is less clear. Pre-KT may worsen access to KT due its negative impact on cognition ability maintain overall health.
Background: Unintentional weight loss, a hallmark of frailty, predicts worse post-kidney transplantation (KT) outcomes. However, loss in candidates with obesity is often recommended to enhance transplant eligibility. We tested whether pre-evaluation change associated listing/waitlist mortality, considering intentionality and frailty. Methods: leveraged data on body mass index (BMI), intentionality, (one-year at evaluation), frailty (four-component Physical Frailty Phenotype evaluation) for...
The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for transplantation only way to solve this problem. To address these problems, current study proposed series novel strategies. For large-volume cartilage regeneration, sheet technique (without any extra materials) was adopted avoid inflammatory reaction triggered by materials form homogeneous, mature autologous goat model. vascularization, flat...
Abstract Frailty predicts adverse outcomes for kidney transplant (KT) patients; yet the impact of clinical assessments frailty on center-level remains unclear. We sought to test whether KT centers that measure as part practice have better pre- and post-KT outcomes. conducted a survey US (11/2017-4/2018), 132 (response rate=65.3%) reported frequencies assessment at candidacy evaluation admission. Center characteristics were gleaned from national registry (2017-2019). Poisson regression was...
Journal of the American Society Nephrology 34(11S):p 341, November 2023. | DOI: 10.1681/ASN.20233411S1341a
Near-infrared fluorescence (NIRF) angiography has been applied for intraoperative visualization of neurovascular circulation and pathologies such as aneurysms, well to enhance contrast in clinical imaging retinal fundus microvasculature. The ability quantitatively evaluate compare the performance NIRF devices including contrast, resolution linearity under biologically realistic, yet reproducible conditions would facilitate innovation translation this technology. Towards development methods...