A5100708670- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- RNA Interference and Gene Delivery
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Gallbladder and Bile Duct Disorders
- Antibiotic Resistance in Bacteria
- Radiation Therapy and Dosimetry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pelvic floor disorders treatments
- Cancer, Hypoxia, and Metabolism
- Platelet Disorders and Treatments
- Natural product bioactivities and synthesis
- Enhanced Recovery After Surgery
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
Xi'an Medical University
2018-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Central South University
2018-2024
Xiangya Hospital Central South University
2018-2024
Hospital of Hebei Province
2024
First Affiliated Hospital of Dalian Medical University
2022-2023
First Affiliated Hospital of Soochow University
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2019-2023
Soochow University
2023
A cell-penetrating lupus anti-DNA antibody inhibits DNA repair, sensitizes cancer cells to DNA-damaging therapy in vitro and vivo, is synthetically lethal BRCA2-deficient human cells.
The development of small-molecule tyrosine kinase inhibitors (TKI) specific for epidermal growth factor receptors (EGFR) with activating mutations has led to a new paradigm in the treatment non-small cell lung cancer (NSCLC) patients. However, most patients eventually develop resistance. Hypoxia is key microenvironmental stress solid tumors that associated poor prognosis due, part, acquired resistance conventional therapy. This study documents long-term, moderate hypoxia promotes EGFR TKI,...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide and a major cause death in cirrhosis. The prognosis HCC poor, with mortality rate close to morbidity rate. Once develops distant metastasis, area affected by cancer cells significantly enlarged, there still no effective treatment for HCC. Therefore, development drugs essential improve survival patients. We designed optimised delivery system compound 1, derived from camptothecin extract, developing...
ABSTRACT In the current period of pharmaceutical discovery, herbal remedies have shown to be an unmatched supply anticancer medications. By changing tumor microenvironment and several signaling pathways, plants their byproducts through analogs important part in therapy for carcinoma. The investigation assessed effectiveness inhibiting development gastric cancer cells HGC‐27 by attenuating PI3K/AKT ERK 1/2 MAPK pathways using natural medicines silibinin (SIL) sulforaphane (SFN) complemented...
Tumor targeting studies using metallic nanoparticles (NPs) have shown that the enhanced permeability and retention effect may not be sufficient to deliver amount of intratumoral intracellular NPs needed for effective in vivo radiosensitization. This work describes a pH-Low Insertion Peptide (pHLIP) targeted theranostic agent enable image-guided NP-enhanced radiotherapy clinically feasible injected NPs. Conventional gadolinium (Gd) were conjugated pHLIPs evaluated vitro radiosensitivity mouse...
Colorectal cancer (CRC) is a common type of malignant tumor the digestive tract. Tumor mutation burden (TMB) potential prognostic indicator numerous tumors. This study investigated value TMB in CRC.This analyzed clinical and somatic data patients with CRC from Memorial Sloan Kettering Cancer Center (MSKCC) The Genome Atlas (TCGA) cohorts. genetic landscape was visualized using maftools package R software. Survival curves were constructed Kaplan-Meier method, Cox regression analysis performed...
Abstract Purpose To investigate the puncture accuracy and feasibility of contrast-enhanced ultrasound (CEUS) guided percutaneous nephrolithotomy (PCNL) in flank position for patients with no apparent hydronephrosis. Methods Between May 2018 June 2020, 72 kidney stone or mild hydronephrosis were randomized into two groups: a CEUS-guided PCNL group conventional (US)-guided group. Patients’ demographics perioperative outcomes compared, including success rate via calyceal fornix, single-needle...
BRCA1-Associated Protein 1 (BAP1) is a deubiquitylase that found associated with multiprotein complexes regulate key cellular pathways, and subsequent researches have revealed BAP1 acts independently as tumor suppressor. Somatic mutations occur in various malignancies, but malignancies arising from mutation of suppressors unexplained tissue proclivity. Whether somatic or expression alteration hepatocellular carcinoma (HCC) influence carcinogenesis immunogenicity still unknown. In this study,...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for many malignant and refractory diseases. However, infections, as the most common complication after transplantation, often lead to poor long-term prognosis of patients. In this study, we collected electronic medical records allo-HSCT recipients with gram-negative bacteria (GNB) infections between January 2012 September 2021, analyzed epidemiological characteristics antibiotic sensitivity, determined...
Infection is the most common complication and cause of death after hematopoietic stem cell transplantation (HSCT). Our study aims to investigate clinical characteristics risk factors for
Purpose In recent years, total neoadjuvant therapy (TNT) has emerged as a new therapeutic strategy against advanced rectal cancer (RC). After administration of TNT, some patients show complete clinical response (cCR) to treatment however, disputes about the effects TNT and alternative plans in case recurrence after cCR still exist. Methods A 100 were included this paper. CR non-CR was observed when these administered with at First Affiliated Hospital Dalian Medical University, China from May...
Abstract Background Burkholderia cepacia (BC) has been detected more and in infected patients recent years. However, as a high-risk population, the clinical characteristics prognosis of BC infection hematopoietic stem cell transplantation (HSCT) have not reported. The purpose this study is to obtain data that will help fill gaps field, provide evidence for reducing mortality rate HSCT patients, guide use antibiotics future. Methods Electronic medical records with who underwent Xiangya...