A5101438646- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Gastrointestinal disorders and treatments
- Statistical Methods in Epidemiology
- Digestive system and related health
Qilu Hospital of Shandong University
2011-2024
Shandong University
2021-2023
It has been reported that the epithelial-mesenchymal transition (EMT) plays an important role in hepatocellular carcinoma (HCC). However, relationship between insulin-like growth factor-1 (IGF-1) and EMT of HCC was not fully elucidated. In present work, we found expression N-cadherin, Vimentin, Snail1, Snail2, Twist1 positively associated with IGF-1R expression, while E-cadherin negatively IGF-1 human samples. Furthermore, observed up-regulated Snail2 Twist1, down-regulated E-cadherin....
BRCA1-Associated Protein 1 (BAP1) is a deubiquitylase that found associated with multiprotein complexes regulate key cellular pathways, and subsequent researches have revealed BAP1 acts independently as tumor suppressor. Somatic mutations occur in various malignancies, but malignancies arising from mutation of suppressors unexplained tissue proclivity. Whether somatic or expression alteration hepatocellular carcinoma (HCC) influence carcinogenesis immunogenicity still unknown. In this study,...
Both phosphorylated signal transducer and activator of transcription 3(pStat-3) integrin αvβ6 can play vital role in the development progression cancer. However, little is known about their expression correlation clinical significance gallbladder cancer(GBC).The aim our present study was to investigate pStat-3 αvβ6, two proteins' GBC tissues.The were both significantly associated with T stage, lymph node metastasis status, TNM stage (P=0.008, P=0.000, P=0.000 P=0.036,...
Pancreatic duct stone is thought not only to be the cause of abdominal pain but also a risk factor for pancreatic cancer. Several treatment options have been implemented in stones. Stone location critical selecting treatment. We present results 27 endoscopic treatments and 35 surgical performed three hospitals at single university between January 2000 2005. The were compared retrospectively terms success rate removal, length hospital stay, complications, relief, changes functions. In our...
Combination immunotherapy has gradually become the mainstay of systematic therapy for advanced hepatocellular carcinoma (HCC), however, whether preoperative potential to reduce tumor activity, increase resection rate and improve prognosis remains unclear. This study aimed investigate efficacy safety combined immunotherapies patients with initially unresectable HCC. retrospective, real-world involved HCC receiving based on PD-1/L1 blockade before surgery. Tumor treatment responses,...
Previous meta-analyses have shown that aspirin use may reduce the risk of hepatocellular carcinoma (HCC). However, optimal dose, frequency, and duration or safety efficacy in target populations for HCC prevention remain unclear. The study aim was to investigate HCC.Publications were retrieved by a comprehensive literature research several databases. Based on random-effects model, hazard ratios (HRs) corresponding 95% confidence intervals (CIs) used assess pooled risk. dose-response...