A5100544035- Cell Adhesion Molecules Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced materials and composites
- Protease and Inhibitor Mechanisms
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Growth Hormone and Insulin-like Growth Factors
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Tunneling and Rock Mechanics
- Digestive system and related health
- Caveolin-1 and cellular processes
- Beetle Biology and Toxicology Studies
- Extracellular vesicles in disease
- Pediatric Hepatobiliary Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Advanced Surface Polishing Techniques
- Congenital Anomalies and Fetal Surgery
- Platelet Disorders and Treatments
Qilu Hospital of Shandong University
2014-2025
Shandong University
2018-2025
Jimei University
2016
Huaqiao University
2016
Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to formation progression. The TME composed of cells, stromal cytokines, chemotactic factors fibroblasts are main components. In our present study, we found that colorectal cancer (CRC) cells expressing integrin αvβ6 clearly could induce morphological changes inactive increased expression activated fibroblast markers such as α-smooth muscle actin (α-SMA) fibroblast-activating protein (FAP)....
Abstract Norcantharidin (NCTD) is an efficacious anti-cancer drug that has been used in China for many years, but its underlying mechanism of action still not fully understood. In the present study, we found NCTD could induce morphological changes colon cancer cells, causing a transition from spindle-shaped morphology to typical round or oval shape, which was indicative mesenchymal-epithelial (MET) process. Next, investigated by induced MET Using transwell assay, suppress migratory and...
Gallbladder polyps (GBPs) are increasingly prevalent, with the majority being benign; however, neoplastic carry a risk of malignant transformation, highlighting importance accurate differentiation. This study aimed to develop and validate interpretable machine learning (ML) models accurately predict GBPs in retrospective cohort, identifying key features providing model explanations using Shapley additive (SHAP) method. A total 924 patients who underwent cholecystectomy between January 2013...
Background: Gallbladder cancer (GBC) is a rare but aggressive malignancy, often detected late due to early asymptomatic stages. Understanding cellular and molecular changes from normal tissue high-grade intraepithelial neoplasia (HGIN) invasive GBC vital for identifying biomarkers therapeutic targets. Methods: We performed single-cell RNA sequencing on 98,113 cells derived 2 adjacent tissues (NAT), HGIN, 6 samples. The diversity heterogeneity, particularly within epithelial immune cell...
Both eukaryotic translation initiation factor 4E (eIF4E) and integrin αvβ6 play an important role in the development progression of cancer. The aim this study was to investigate expression eIF4E Integrin αvβ6, their clinical significance as well two proteins' correlation colonic carcinoma tissues.The levels were analyzed colon cancerous paraneoplastic tissues 138 cases via tissue microarray (TMA)- immunohistochemistry. And also investigated. significantly associated with TNM stage (P =...
It has been reported that the epithelial-mesenchymal transition (EMT) plays an important role in hepatocellular carcinoma (HCC). However, relationship between insulin-like growth factor-1 (IGF-1) and EMT of HCC was not fully elucidated. In present work, we found expression N-cadherin, Vimentin, Snail1, Snail2, Twist1 positively associated with IGF-1R expression, while E-cadherin negatively IGF-1 human samples. Furthermore, observed up-regulated Snail2 Twist1, down-regulated E-cadherin....
The aim of this study is to investigate the expressions somatostatin receptor (SSTR), SSTR-2, SSTR-3, and SSTR-5, in pancreatic tissue non-cancerous elucidate their clinical significance. expression subtypes SSTR-5 messenger RNA (mRNA) 108 cases cancer adjacent patients with was detected by reverse transcriptase polymerase chain reaction (RT-PCR). Expression mRNA evaluated after specimens were taken from selected who underwent surgical resection Whipple's operation. We speculated...
Objective Cholangiocarcinoma (CHOL) is a deadly cancer worldwide with limited available therapies. The aim of this study was to investigate key exosomal miRNAs and their functions in CHOL development. Methods Serum exosomes were isolated from patients healthy controls, followed by miRNA sequencing for identifying differentially expressed (DEMs) functions. Then, the expression DEMs experimentally validated clinical cells. effects overexpression on cell migration proliferation investigated. A...
SEC61G is an oncogene in hepatocellular carcinoma (HCC), a common malignant tumor worldwide. MicroRNAs (miRNAs) regulation of oncogenes are available therapeutic strategies being investigated HCC, but the effective miRNA delivery remains challenge. Here, we potential effects miRNA-loaded engineered exosomes patients with HCC. MiRNAs that could bind to were screened using Targetscan, and verified HepG2 cells viability after transfecting miRNAs mimic. Five binding SEC61G，among which,...