A5076107114- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiation Effects and Dosimetry
- Advances in Oncology and Radiotherapy
- Effects of Radiation Exposure
- MRI in cancer diagnosis
- Digital Radiography and Breast Imaging
- Ultrasound and Hyperthermia Applications
- Atomic and Subatomic Physics Research
- Quantum Chromodynamics and Particle Interactions
- Nuclear reactor physics and engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Quantum, superfluid, helium dynamics
- Radiation Effects in Electronics
- Head and Neck Cancer Studies
Institute of Cancer Research
2016-2025
Royal Marsden NHS Foundation Trust
2016-2025
Royal Marsden Hospital
2017-2025
Sutton Hospital
2021
Institute of Cancer Research
2020
National Health Service
2017-2019
Hospital de São João
2019
Kokilaben Dhirubhai Ambani Hospital
2019
German Cancer Research Center
2009-2018
Heidelberg University
2009-2018
Abstract Background To determine whether proton radiotherapy has clinical advantages over photon radiotherapy, we modeled the dose characteristics of both to critical normal tissue volumes using data from patients with four types childhood brain tumors. Procedures Three‐dimensional imaging and treatment planning data, including targeted tumor tissues contours, were acquired for 40 patients, 10 each optic pathway glioma (OPG), craniopharyngioma (CR), infratentorial ependymoma (EP), or...
The sharp dose gradients which are possible in intensity modulated proton therapy (IMPT) not only offer the possibility of generating excellent target coverage while sparing neighbouring organs at risk, but can also lead to treatment plans very sensitive uncertainties variables such as range individual Bragg peaks. We developed a method account for optimization based on worst case distribution. distribution is calculated using several realizations uncertainties. This information used by...
To study the effects of a variable relative biological effectiveness (RBE) in inverse treatment planning for proton therapy, fast methods three-dimensional RBE calculations are required. We therefore propose simple phenomenological model therapeutic beams. It describes as function dose, linear energy transfer (LET) and tissue specific parameters. Published experimental results dependence parameters alpha beta from linear-quadratic on dose averaged LET were evaluated. Using alpha(LET)...
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
Abstract For multimodality therapies such as the combination of hyperthermia and radiation, quantification biological effects is key for dose prescription response prediction. Tumour spheroids have a microenvironment that more closely resembles tumours in vivo may thus be superior vitro cancer model than monolayer cultures. Here, tumour formed from two established human cell lines (HCT116 CAL27) to single treatments radiation (0–20 Gy), at 47 °C (0–780 CEM 43 ) has been evaluated. Response...
Background and purposeThere are concerns that radiotherapy doses delivered in a magnetic field might be distorted due to the Lorentz force deflecting secondary electrons. This study investigates this effect on lung stereotactic body (SBRT) treatments, conducted either with or without multileaf collimator (MLC) tumor tracking.Material methodsLung SBRT treatments an MR-linac were simulated for nine patients. Two different treatment techniques compared: conventional, non-tracked deliveries...
PurposeA study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery and institutions, dosimetric accuracy is improved with treatments over non-adaptive in presence patient-measured tumor motion.Methods materialsTen institutions robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT structure sets, motion traces planning protocols create a lung prostate plan. For each trace, plan delivered twice moving...
PurposeThe POP-ART RT study aims to determine what extent and how intrafractional real-time respiratory motion management (RRMM), plan adaptation for interfractional anatomical changes (ART) are used in clinical practice understand barriers implementation. Here we report on part II: ART using more than one per target treatment course.Materials methodsA questionnaire the current of ART, wishes expansion or implementation, implementation was distributed worldwide. Four types were...
IntroductionMR-guided adapted radiotherapy (MRgART) using a high field MR-linac has recently become available. We report the estimated delivered fractional dose of first five prostate cancer patients treated at our centre MRgART and compare this to C-Arm linac daily Image Guided Radiotherapy (IGRT).MethodsPatients were treatment plans shaped their anatomy. The treatments recalculated on an MR image acquired immediately prior delivery in order estimate dose. C-arm non-adapted VMAT same images...
A new online imaging approach, linac-integrated cone beam CT (CBCT), has been developed over the past few years. It advantage that a patient can be examined in their treatment position directly before or during radiotherapy treatment. Unfortunately, respiratory organ motion, one of largest intrafractional motions, often leads to artefacts reconstructed 3D images. One way take this into account is register breathing phase image acquisition for phase-correlated reconstruction. Therefore, main...
The feasibility of using PET for proton dose monitoring is examined here in detail. First experimental studies a Lucite phantom have been performed at the medical TRIUMF beamline energies 62 MeV and 110 MeV. delivered to ranged from 16 Gy up 317 Gy. induced activity was analysed 20 - 40 min after irradiation with scanner.
In this paper, we investigate an off-line strategy to incorporate inter-fraction organ motion in IMRT treatment planning. It was suggested that inverse planning could be based on a probability distribution of patient geometries instead single snap shot. However, concept is connected two intrinsic problems: first, has estimated from only few images; and second, the sparsely sampled over course due finite number fractions. current work, develop new concepts which account for these problems.
The aim of this treatment planning study was to investigate the potential advantages intensity-modulated (IM) proton therapy (IMPT) compared with IM photon (IMRT) in nasopharyngeal carcinoma (NPC). Eight NPC patients were chosen. dose prescriptions cobalt Gray equivalent (GyE) for gross tumor volumes primary (GTV-T), target GTV-T and metastatic (PTV-TN) elective (PTV-N) lymph node stations 72.6 GyE, 66 52.8 respectively. For each patient, nine coplanar fields IMRT step-and-shoot technique 3D...
A method for simulating spot-scanned delivery to a moving tumour was developed which uses patient-specific image and plan data. The magnitude of interplay effects investigated two patient cases under different fractionation respiratory motion variation scenarios. use volumetric rescanning mitigation also investigated. For beam arrangements, lead severely distorted dose distributions single fraction delivery. Baseline shift variations reduced the clinical target volume (CTV) by up 14.1 Gy....
Spectroscopic x-ray imaging by means of photon counting detectors has received growing interest during the past years. Critical to image quality such devices is their pixel pitch and sensor material employed. This paper describes properties Medipix2 MXR multi-chip assemblies bump bonded 1 mm thick CdTe sensors. Two systems were investigated with pitches 110 165 μm, which are in order mean free path lengths characteristic x-rays produced Peak widths found be almost constant across energy...
Prediction of respiratory motion is essential for real-time tracking lung or liver tumours in radiotherapy to compensate system latencies. This study compares the performance prediction based on linear regression (LR), neural networks (NN), kernel density estimation (KDE) and support vector (SVR) various sampling rates latencies ranging from 0.2 0.6 s. Root-mean-squared errors are evaluated 12 3D tumour traces acquired at 30 Hz during treatments. The effect stationary predictor training...
The aim of this work was to compare and validate various computed tomography (CT) number calibration techniques with respect cone beam CT (CBCT) dose calculation accuracy. CBCT accuracy assessed for pelvic, lung, head neck (H&N) treatment sites two approaches: (1) physics-based scatter correction methods (CBCTr); (2) density override approaches including assigning water the entire (W), assignment either or bone (WB), lung (WL). Methods within a commercially available planning system...