A5015694488- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Stellar, planetary, and galactic studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Astrophysics and Star Formation Studies
- Advanced MRI Techniques and Applications
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- Astro and Planetary Science
- Nuclear Physics and Applications
- Prostate Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Atmospheric and Environmental Gas Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Digital Radiography and Breast Imaging
- Spectroscopy and Laser Applications
- Cardiac Imaging and Diagnostics
- Cancer Treatment and Pharmacology
- Voice and Speech Disorders
- Renal and Vascular Pathologies
- Breast Cancer Treatment Studies
- Particle Accelerators and Free-Electron Lasers
Aarhus University Hospital
2013-2024
University Medical Center Utrecht
2016
Utrecht University
2016
Aarhus University
2007-2014
The University of Sydney
2011
PurposeA study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery and institutions, dosimetric accuracy is improved with treatments over non-adaptive in presence patient-measured tumor motion.Methods materialsTen institutions robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT structure sets, motion traces planning protocols create a lung prostate plan. For each trace, plan delivered twice moving...
Couch and MLC tracking are two promising methods for real-time motion compensation during radiation therapy. So far, couch experiments have mainly been performed by different research groups, no direct comparison of volumetric modulated arc therapy (VMAT) plans has published. The Varian TrueBeam 2.0 accelerator includes a prototype system with selectable or compensation. This study provides the types an otherwise identical setup.Several were to characterize geometric dosimetric performance...
Large Digital Imaging and Communications in Medicine (DICOM) datasets are key to support research the development of machine learning technology radiotherapy (RT). However, tools for multi-centre data collection, curation standardisation not readily available. Automated batch DICOM export solutions were demonstrated a multicentre setup. A Python solution, Collaborative analysis RT (CORDIAL-RT) was developed curation, standardisation, collected data. The setup DBCG RT-Nation study, where 86%...
Purpose In radiotherapy, dose deficits caused by tumor motion often far outweigh the discrepancies typically allowed in plan‐specific quality assurance ( QA ). Yet, is not usually included present . We here a novel method for online treatment verification real‐time motion‐including four‐dimensional (4D) reconstruction and evaluation demonstrate its use during stereotactic body radiotherapy SBRT ) delivery with without MLC tracking. Methods Five volumetric‐modulated arc therapy VMAT plans...
Background. Tumor motion during radiotherapy delivery can substantially deteriorate the target dose distribution. A promising method to overcome this problem is dynamic multi-leaf collimator (DMLC) tracking. The purpose of phantom study was integrate a wired electromagnetic (EM) transponder localization system with DMLC tracking and investigate geometric accuracy integrated system. Material methods. experiments were performed on Trilogy accelerator prototype implantable EM mounted stage 3 mm...
Aims.We seek to study excitation mechanisms in the inner region of Orion Molecular Cloud by comparing observations ortho- and para-lines H2 with theoretical models slow shocks photodissociation regions.
Purpose: The highly conformal doses delivered by volumetric modulated arc therapy (VMAT) may be compromised intrafraction target motion. Although dynamic multileaf collimator (DMLC) tracking can mitigate the dosimetric impact of motion on accumulated dose, residual errors still exist. purpose this study was to investigate temporal evolution dose throughout VMAT treatments with and without DMLC tracking. Methods: Tracking experiments were performed a linear accelerator connected prototype...
Multileaf collimator (MLC) tracking is a promising and clinically emerging treatment modality for radiotherapy of mobile tumours. Still, new quality assurance (QA) methods are warranted to safely introduce MLC in the clinic. The purpose this study was create experimentally validate simple model fast motion-including dose error reconstruction applicable intrafractional QA treatments moving targets.
Background. The increasing complexity of radiotherapy (RT) has motivated research into three-dimensional (3D) dosimetry. In this study we investigate the use 3D dosimetry with polymerizing gels and optical computed tomography (optical CT) as a verification tool for complex RT: dose painting target tracking. Materials Methods. For studies, two dosimeters were irradiated seven-field intensity modulated (IMRT) plan without prescription based on hypoxia image dataset head neck patient. tracking...
<i>Context. <i/>Shocks produced by outflows from young stars are often observed as bow-shaped structures in which the H<sub>2<sub/> line strength and morphology characteristic of physical chemical environments velocity impact. <i>Aims. <i/>We present a 3D model interstellar bow shocks propagating homogeneous molecular medium with uniform magnetic field. The enables us to estimate shock conditions flows. As an example, we show how can reproduce rovibrational observations OMC1.<i>Methods....
Couch and MLC tracking are two novel techniques to mitigate intrafractional tumor motion on a conventional linear accelerator, but both still have residual dosimetric errors. Here, we first propose experimentally validate software tool simulate couch tracking, then use the simulator study hybrid couch-MLC for improved performance.The requires treatment plan trajectory as input simulates delivered monitor units of all accelerator parts function time. The outputs log files synchronized with...
Hypofractionation in prostate radiotherapy is of increasing interest. Steep dose gradients and a large weight on each individual fraction emphasize the need for motion management. Real-time management techniques such as multileaf collimator (MLC) tracking or couch typically adjust translational while rotations remain uncompensated with unknown dosimetric impact.The purpose this study to demonstrate validate dynamic real-time rotation-including reconstruction during experiments without MLC...
During prostate stereotactic body radiation therapy (SBRT), tumor translational motion may deteriorate the planned dose distribution. Most of major advances in management to date have focused on correcting this one aspect motion, translation. However, large rotation up 30° has been measured. As technological innovation evolves toward delivering increasingly precise radiotherapy, it is important quantify clinical benefit and rotational correction over alone.The purpose work was dosimetric...
Aims.We present a new method for reproducing high spatial resolution observations of bow shocks by using 1D plane parallel shock models. As an example we analyse one located in the Orion Molecular Cloud (OMC1).
Organ motion during treatment delivery in radiotherapy (RT) may lead to deterioration of the planned dose, but can be mitigated by dynamic multi-leaf collimator (DMLC) tracking. The purpose this study was implement and experimentally validate a method for time-resolved including dose reconstruction volumetric modulated arc therapy (VMAT) treatments delivered with without DMLC tracking.Tracking experiments were carried out on linear accelerator (Trilogy, Varian) prototype tracking system. A...
Purpose In radiotherapy, tumor motion may deteriorate the planned dose distribution. However, dosimetric consequences of are normally unknown for individual treatments. We here present a method real‐time motion‐including reconstruction and demonstrate its use simulated stereotactic body radiotherapy (SBRT) patients with liver cancer previously treated Calypso‐guided gating. Methods Real‐time was performed using in‐house developed software, DoseTracker, on offline replays previous clinical...
The outcome of radiotherapy is a direct consequence the dose delivered to patient. Yet image-guidance and motion management date focus on geometrical considerations as practical surrogate for dose. Here, we propose real-time dose-guidance realized through continuous motion-including reconstructions demonstrate this new concept in simulated liver stereotactic body (SBRT) delivery.During SBRT delivery, in-house developed software performed reconstruction tumor so far continuously predicted...
Abstract An in-house developed program for real-time reconstruction of motion-induced dose errors, DoseTracker, was extended to handle rotational target motion in addition the previously implemented translational motion, and applied offline prostate VMAT treatments. For errors DoseTracker were good agreement with ground truth reconstructions performed a commercial treatment planning system. no available, but showed that is highly robust against static interfractional rotations quite...
Visual inspections of anatomical changes observed on daily cone-beam CT (CBCT) images are often used as triggers for radiotherapy plan adaptation to avoid unacceptable dose levels the target or OARs. Direct CBCT calculations would improve ability adapt only those plans where dosimetric observed. This study investigates accuracy CBCTs.Calibration curves were obtained imagers at nine identical accelerators. scans a phantom with different density inserts recorded two scan modes (Head-Neck and...
Abstract Background Radiotherapy of the prostate and pelvic lymph nodes (LN) is a part standard care treatment for high‐risk cancer. The independent translational rotational (i.e., six‐degrees‐of‐freedom, [6DoF]) motion LN target during between fractions can perturb dose distribution. However, no reconstruction method accounting differential 6DoF available. Purpose We present framework monitoring motion‐induced perturbations two independently moving volumes in 6DoF. was used to determine...