A5022738856- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Management of metastatic bone disease
- Chemotherapy-induced cardiotoxicity and mitigation
- Radiation Dose and Imaging
- Brain Metastases and Treatment
- Housing, Finance, and Neoliberalism
- Breast Lesions and Carcinomas
- Healthcare innovation and challenges
- Photoacoustic and Ultrasonic Imaging
- Head and Neck Cancer Studies
- Employment and Welfare Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrhythmias and Treatments
- Spine and Intervertebral Disc Pathology
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- Social Issues and Policies
- Ultrasound Imaging and Elastography
- Wireless Power Transfer Systems
- Delphi Technique in Research
Siemens Healthcare (United States)
2022-2024
Royal Alexandra Hospital
2024
Health Sciences Centre
2014-2023
Varian Medical Systems (United States)
2022-2023
Sunnybrook Health Science Centre
2014-2023
University of California, San Diego
2023
Varian Medical Systems (Canada)
2023
University of Toronto
2004-2022
Rhodes University
2020
Sunnybrook Research Institute
2015
To our knowledge, there have been no clinical trials of ultra-high-dose-rate radiotherapy delivered at more than 40 Gy/sec, known as FLASH therapy, nor first-in-human use proton FLASH.To assess the workflow feasibility and treatment-related toxic effects pain relief treatment sites.In FAST-01 nonrandomized trial, participants treated Cincinnati Children's/UC Health Proton Therapy Center underwent palliative to extremity bone metastases. Patients 18 years older with 1 3 painful metastases...
Abstract Background FLASH therapy is a treatment technique in which radiation delivered at ultra-high dose rates ( ≥ 40 Gy/s). The first-in-human FAST-01 clinical trial demonstrated the feasibility of proton extremity bone metastases. objectives this investigation are to assess toxicities and pain relief study participants with painful thoracic metastases treated radiotherapy, as well workflow metrics setting. Methods This single-arm being conducted under an FDA investigational device...
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
Background In preclinical studies, FLASH therapy, in which radiation delivered at ultrahigh dose rates of ≥40 Gy per second, has been shown to cause less injury normal tissues than radiotherapy conventional rates. This paper describes the protocol for first-in-human clinical investigation proton therapy. Objective FAST-01 is a prospective, single-center trial designed assess workflow feasibility, toxicity, and efficacy therapy treatment painful bone metastases extremities. Methods Following...
To explore men's views of a pedometer-based walking program, part weight-management intervention delivered through Scottish Premier League football clubs, and the congruence or challenge this poses to masculine identities.Semistructured telephone interviews with sample participants in gender-sensitized, group program. Interviewing continued until data saturation was reached (n = 29).All men were positive about context, style delivery, content broader intervention. These things encouraged...
Introduction: Evaluating and training strength qualities is crucial for the physical development of ballet dancers. Whilst data available as to sensitivity tests detecting changes in athlete populations, between-session reliability adolescent dancers yet be determined. This study aimed determine performance elite Methods: Depending on test, a cohort 25 54 pre-professional (9 -30 males, 14-29 females) participated series 6 across 12 sessions. Each testing session involved performing 1 with...
This study examined relationship factors associated with parental dysfunction among young African American and Latino couples. Parent was defined in terms of parenting stress, child abuse potential, physically punitive behavior, paternal disengagement. Fathers who reported positive relations their own parents partners before childbirth more adjustments to parenthood at follow-up. The quality the prebirth partner buffered impact a breakup on father's adjustment parenthood. mother's her best...
To develop a multipurpose gel-based breast phantom consisting of simulated tumor with realistic imaging properties in CT, ultrasound and MRI, or postsurgical cavity on CT. Applications for the include: deformable image registration (DIR) quality assurance (QA), autosegmentation validation, localization testing training minimally invasive image-guided procedures such as those involving catheter needle insertion.A thermoplastic mask typical patient lying supine was generated then filled to...
The overarching objective of this article is to stimulate debate about how local authorities could and should manage their austerity measures because the speed, scale aggregation UK public spending cuts risk adversely affecting already disadvantaged vulnerable groups, exacerbating social exclusion leading higher costs for councils in future. It presents results research conducted during 2011–2012 focusing on if five Scottish case study attempted mitigate risks. found that they were using...
Knee osteoarthritis is a leading cause of chronic disability and economic burden. In many patients who are not surgical candidates, existing treatment options insufficient. Clinical evidence for new approach, genicular artery embolisation (GAE), currently limited to single arm cohort, or small population randomised studies. This trial will investigate the use permanent embolic agent abnormal arterial vasculature reduce pain in with mild moderate knee osteoarthritis. Up 110 participants, 45...
Hypofractionated partial breast irradiation (HPBI) involves treatment to the tumor using high doses per fraction. Recent advances in MRI-Linac solutions have potential being applied HPBI due gains soft tissue contrast of MRI; however, there are potentially deleterious effects magnetic field on dose distribution. The purpose this work is determine distribution for tumors a tangential beam arrangement (TAN), 5-beam intensity-modulated radiation therapy (IMRT), and volumetric modulated arc...
This paper reports case study research, the results of which are used to consider whether councils have recognised potentially substantially increased social risks they may create as seek reduce their spending in line with UK Government’s programme public sector austerity. It discusses conceptual shift risk management literature towards (SRM), presents empirical evidence and considers approach SRM developed by other organisations. finds no within authorities so advocates a culture from...
Management of locally-advanced breast cancer is determined by multiple factors, but in patients without distant metastases often involves neoadjuvant systemic therapy, surgery and radiation. If the primary tumour remains unresectable following radiotherapy may be used for shrinkage prior to surgery. When metastatic disease present, locoregional generally reserved management tumour-related symptoms. We reviewed our experience high-dose unresected cancer.A retrospective chart review was...
Major surgery accounts for a substantial proportion of health service activity, due not only to the primary procedure, but longer-term implications poor short-term outcome. Data from small studies or outside UK indicate that rates complications and failure rescue vary between hospitals, as does compliance with best practice processes. Within UK, there is currently no system monitoring postoperative (other than mortality) in major non-cardiac surgery. Further, variation national audit...
After breast conserving surgery, early stage cancer patients are currently treated with a wide range of radiation techniques including whole irradiation (WBI), accelerated partial (APBI) using high dose rate (HDR) brachytherapy, or 3D conformal radiotherapy (3D-CRT). This study compares the mean heart's doses for left irradiated different techniques. An anthropomorphic Rando phantom was modified gelatin-based sizes and tumors located medially laterally. The breasts were WBI, 3D-CRT HDR APBI....
This study examined relationship factors associated with parental dysfunction among young African American and Latino couples. Parent was defined in terms of parenting stress, child abuse potential, physically punitive behavior, paternal disengagement. Fathers who reported positive relations their own parents partners before childbirth more adjustments to parenthood at follow-up. The quality the prebirth partner buffered impact a breakup on father's adjustment parenthood. mother's her best...
Today, radiation therapy (RT) is moving toward increased dose to the tumor as a result of 3D conformal RT (3DCRT) and intensity-modulated (IMRT), which have been made possible by advances in volumetric-based image planning with digital imaging systems such computed tomography (CT). Treatment for requires superior CT quality. Our goal this study was evaluate compare quality three unique simulation scanners available at our center both single- multiple-slice helical scanners. These included...