A5100357092- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Advanced Radiotherapy Techniques
- Cancer survivorship and care
- Brain Metastases and Treatment
- Palliative Care and End-of-Life Issues
- Acute Myeloid Leukemia Research
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Effects of Radiation Exposure
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Nonmelanoma Skin Cancer Studies
- Corneal Surgery and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Childhood Cancer Survivors' Quality of Life
- Bladder and Urothelial Cancer Treatments
- Nausea and vomiting management
- Lung Cancer Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Pain Management and Opioid Use
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
University of Toronto
2015-2025
Soochow University
2015-2025
First Affiliated Hospital of Soochow University
2015-2025
Ottawa Hospital
2012-2024
Gansu University of Traditional Chinese Medicine
2018-2024
University of California, Los Angeles
2023-2024
Affiliated Hospital of Guizhou Medical University
2022-2024
China Medical University
2024
Active surveillance is increasingly accepted as a treatment option for favorable-risk prostate cancer. Long-term follow-up has been lacking. In this study, we report the long-term outcome of large active protocol in men with cancer.In prospective single-arm cohort study carried out at single academic health sciences center, 993 favorable- or intermediate-risk cancer were managed an initial expectant approach. Intervention was offered prostate-specific antigen (PSA) doubling time less than 3...
Purpose We assessed the outcome of a watchful-waiting protocol with selective delayed intervention by using clinical prostate-specific antigen (PSA), or histologic progression as treatment indications for clinically localized prostate cancer. Patients and Methods This was prospective, single-arm, cohort study. were managed an initial expectant approach. Definitive offered to those patients PSA doubling time less than 3 years, Gleason score (to 4 + greater), unequivocal progression. Survival...
Cell-cell adhesion mediated by ICAM-1 and VCAM-1 is critical for T cell activation leukocyte recruitment to the inflammation site and, therefore, plays an important role in evoking effective immune responses. However, we found that were mesenchymal stem (MSC)-mediated immunosuppression. When MSCs cocultured with cells presence of Ag receptor activation, they significantly upregulated adhesive capability due increased expression VCAM-1. By comparing immunosuppressive effect toward various...
To assess the applicability of active surveillance in patients with intermediate risk prostate cancer, we compared survival outcomes low and disease.Active was offered to all (cT1-T2b Gleason score 6 specific antigen 10 ng/ml or less) select disease (age greater than 70 years cT2c 15 less, 3+4 less). Data from November 1995 May 2013 were extracted a prospectively collected database. The primary outcome metastasis-free survival, secondary overall cause treatment-free survival.A total 213 732...
Many finite element models have been developed by several research groups in order to achieve a better understanding of brain injury. Due the lack experimental data, validation these has generally limited. Consequently, applying investigate responses also Over last years, versions Wayne State University injury model (WSUBIM) were developed. However, none is capable simulating indirect impacts with an angular acceleration higher than 8,000 rad/s(2). Additionally, density and quality mesh...
Mesenchymal stem cells (MSC) are present in most, if not all, tissues and believed to contribute tissue regeneration the immune microenvironment. Murine MSCs exert immunosuppressive effects through production of inducible nitric oxide synthase (iNOS), whereas human use indoleamine 2,3-dioxygenase (IDO). Thus, studies MSC-mediated immunomodulation mice may be informative setting disease, although this critical difference has been mainly ignored. To address issue, we established a novel...
Purpose: To determine whether admission computed tomography (CT) perfusion–derived permeability–surface area product (PS) maps differ between patients with hemorrhagic acute stroke and those nonhemorrhagic stroke. Materials Methods: This prospective study was institutional review board approved, all participants gave written informed consent. Forty-one who presented within 3 hours after symptom onset underwent two-phase CT perfusion imaging, which enabled PS measurement. Patients were...
To systematically evaluate the diagnostic benefits and inter- intraobserver reliability of an incremental computed tomographic (CT) protocol in confirmation clinically suspected stroke, with combined imaging clinical data as reference standard.Institutional review board approval was obtained, participants gave informed consent. A total 191 patients (mean age, 67 years +/- 16 [standard deviation]; 105 men) strokelike symptoms no more than 3 hours duration were recruited. Blinded performed by...
Key Points CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities). Serum interleukin-6 is elevated in people genetic subtypes, providing a view of the human systemic inflammatory landscape CH.
Active surveillance is an approach to low and intermediate risk prostate cancer that designed decrease overtreatment. Despite close monitoring a small subset of patients progress metastatic disease. We analyzed the clinical pathological correlates in who eventually experienced metastasis.This was single center, prospective cohort study. Eligible were treated with expectant approach. The main outcome measure metastasis-free survival. Predictive factors for metastasis identified.Metastasis...
Obesity-associated inflammation is accompanied by the accumulation of adipose tissue macrophages (ATMs), which believed to predispose obese individuals insulin resistance. CD11b (integrin αM) highly expressed on monocytes and critical for their migration function. We found here that high-fat diet-induced resistance was significantly reduced in CD11b-deficient mice. Interestingly, recruitment impaired when deficient, although cellularity ATMs mice higher than wild-type further increase caused...
The Movember Foundation launched the Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative to create a global consensus on selection and monitoring of men with low-risk prostate cancer (PCa) active surveillance (AS). aim this study is present data inclusion follow-up for AS in unique database.Between 2014 2016, database was created by combining patient from 25 established cohorts worldwide (USA, Canada, Australasia, UK Europe). Data total 15 101 patients were included....
<h3>BACKGROUND AND PURPOSE:</h3> Good CTA collaterals independently predict good outcome in acute ischemic stroke. Our aim was to evaluate the role of collateral circulation and its added benefit over CTP-derived total volume as a predictor baseline NIHSS score, volume, hemorrhagic transformation, final infarct size, modified Rankin Scale score >2. <h3>MATERIALS METHODS:</h3> This retrospective study 395 patients with stroke dichotomized by recanalization (recanalization...
Summary Little is known about the effects of frailty, disability and physical functioning on clinical outcomes for myelodysplastic syndromes ( MDS ). We investigated predictive value these factors overall survival OS ) in 445 consecutive patients with chronic monomyelocytic leukaemia CMML enrolled a multi‐centre prospective national registry. Frailty, comorbidity, instrumental activities daily living, disability, quality life, fatigue performance measures were evaluated at baseline added as...
Radiation dermatitis (RD) is common in patients undergoing breast radiotherapy. Mepitel film (MF) can reduce RD, but the results from two randomized controlled trials are conflicting. We aimed to conduct a confirmatory trial at risk of RD.Patients were randomly assigned receive MF or standard care (2:1 ratio). Patients with large breasts after lumpectomy (bra size ≥ 36 inches cup C) mastectomy eligible. Stratification factors included surgery type, dose fractionation, and administration...