A5091337350- Prostate Cancer Treatment and Research
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Renal cell carcinoma treatment
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Estrogen and related hormone effects
- Melanoma and MAPK Pathways
- Testicular diseases and treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Glutathione Transferases and Polymorphisms
- Renal Transplantation Outcomes and Treatments
- Urinary and Genital Oncology Studies
University of Pennsylvania
2015-2024
California University of Pennsylvania
2023-2024
Hospital of the University of Pennsylvania
2013-2024
Safdarjang Hospital
2024
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2012-2023
Institute of Medical Sciences
2022-2023
Hospital Médica Sur
2023
UCSF Helen Diller Family Comprehensive Cancer Center
2022
University of Mississippi
2022
Lagos University Teaching Hospital
2022
We report the aberrantly strong nuclear immunoreactivity for C-terminal portion of TFE3 protein in tumors characterized by chromosome translocations involving gene at Xp11.2. This group includes alveolar soft part sarcoma and a specific subset renal carcinomas that tend to affect young patients. They contain fusion genes encode chimeric proteins consisting N-terminal different translocation partners fused TFE3. postulated expression these may be dysregulated detectable immunohistochemistry....
Abstract Purpose: The G1–S checkpoint of the cell cycle is frequently dysregulated in breast cancer. Palbociclib (PD0332991) an oral inhibitor CDK4/6. Based upon preclinical/phase I activity, we performed a phase II, single-arm trial palbociclib advanced Experimental Design: Eligible patients had histologically confirmed, metastatic cancer positive for retinoblastoma (Rb) protein and measureable disease. was given at 125 mg orally on days 1 to 21 28-day cycle. Primary objectives were tumor...
We studied the inverse relationship between HER-2 and estrogen (ER) progesterone (PR) receptors using testing correlated status with histologic features in 3,655 unselected invasive breast carcinomas. Immunohistochemical analysis for ER, PR, fluorescence situ hybridization were performed. ER PR expression decreased significantly HER-2+ tumors compared HER-2– (ER, 49.1% vs 78.17%; 24.3% 53.13%). Even among tumors, rate of or high-grade was intermediate-grade tumors. positive 10.87% grade 2...
We studied the ethnicity-specific expression of prostate cancer (PC) -associated biomarkers to evaluate whether genetic/biologic factors affect ethnic disparities in PC pathogenesis and disease progression.
Metastatic castration-resistant prostate cancer (CRPC) is a fatal disease, primarily resulting from the transcriptional addiction driven by androgen receptor (AR). First-line CRPC treatments typically target AR signaling, but are rapidly bypassed, in only modest survival benefit with antiandrogens. Therapeutic approaches that more effectively block AR-transcriptional axis urgently needed. Here, we investigated molecular mechanism underlying association between coactivator MED1 and as...
Significance Despite measurable advances in cancer treatment, patients with glioblastoma multiforme (GBM) typically survive only 12–14 mo because of tumor recurrence. Tumor hypoxia has been associated chemoresistance. We hypothesized that the pronounced repression microRNA-218 ( miR-218 ) observed samples from highly hypoxic and necrotic GBM contributes to this recurrent phenotype. demonstrate here mice harboring intracranial tumors increased expression exhibit significantly reduced burden...
The role of immune-oncologic mechanisms racial disparities in prostate cancer remains understudied. Limited research exists to evaluate the molecular underpinnings immune differences African American men (AAM) and European (EAM) tumor microenvironment (TME).A total 1,173 radiation-naïve radical prostatectomy samples with whole transcriptome data from Decipher GRID registry were used. Transcriptomic expressions 1,260 immune-specific genes selected assess between AAM EAM tumors. Race-specific...
We analyzed concordance between immunohistochemical analysis and fluorescence in situ hybridization (FISH) HER-2 status studied the effect of dual-color (D-FISH) vs single-color FISH (S-FISH) scoring on assignment tumors to amplified or nonamplified categories. The assays were performed formalin-fixed, paraffin-embedded sections 2,279 invasive breast carcinomas. Immunohistochemical results interpreted as negative (0, 1+) positive (2+, 3+). For analyses, a ratio for HER-2/chromosome 17 2.0...
Inactivation of the von-Hippel Lindau (VHL) tumor suppressor gene occurs in 90% human clear cell renal carcinomas (ccRCC) and leads to stable expression hypoxia-inducible factors HIF1α HIF2α. The constitutive a majority VHL-deficient tumors is counterintuitive, given that functions as ccRCC, whereas HIF2α clearly enhances growth. We demonstrate here miR-30c-2-3p miR-30a-3p specifically bind inhibit HIF2A transcripts, locus encoding selectively repressed "H1H2" expressing both proteins....
BACKGROUND Alterations in the retinoblastoma pathway germ cell tumors (GCTs) have been described. In phase 1 trials of selective cyclin‐dependent kinase 4/6 inhibitor palbociclib, 3 patients with unresectable, growing, mature teratoma syndrome achieved prolonged disease stabilization. The authors conducted an open‐label, 2 study to determine efficacy and safety palbociclib incurable, refractory, protein (pRB)‐expressing GCTs. METHODS Patients who had refractory GCTs that demonstrated pRB...
Abstract Purpose: Between 30%–40% of patients with prostate cancer experience disease recurrence following radical prostatectomy. Existing clinical models for risk prediction do not account population-based variation in the tumor phenotype, despite recent evidence suggesting presence a unique, more aggressive phenotype African American (AA) patients. We investigated capacity digitally measured, population-specific phenotypes intratumoral stroma to create improved Experimental Design: This...
Abstract Aim Allograft rejection is a serious concern in heart transplant medicine. Though endomyocardial biopsy with histological grading the diagnostic standard for rejection, poor inter-pathologist agreement creates significant clinical uncertainty. The aim of this investigation to demonstrate that cellular grades generated via computational analysis are on-par those provided by expert pathologists Methods and results study cohort consisted 2472 slides originating from three major US...