A5056770711- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hormonal and reproductive studies
- Statistical Methods in Clinical Trials
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Mass Spectrometry Techniques and Applications
- Sperm and Testicular Function
- Protease and Inhibitor Mechanisms
- Microfluidic and Bio-sensing Technologies
- Blood Coagulation and Thrombosis Mechanisms
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Advanced Proteomics Techniques and Applications
- Peptidase Inhibition and Analysis
- Genetic Associations and Epidemiology
- Microfluidic and Capillary Electrophoresis Applications
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Estrogen and related hormone effects
Memorial Sloan Kettering Cancer Center
2016-2025
Lund University
2016-2025
Skåne University Hospital
2013-2025
University of Turku
1996-2023
Turku Centre for Biotechnology
1993-2023
Howard Hughes Medical Institute
2023
University of Oxford
2013-2022
Kettering University
2004-2022
John Wiley & Sons (United States)
2015-2021
Johns Hopkins University
2005-2021
Available standard intrauterine growth curves based on birthweights underestimate foetal in preterm period. New are presented data from four Scandinavian centres for 759 ultrasonically estimated weights 86 uncomplicated pregnancies. Mean weight of boys exceeded that girls by 2‐3%. A uniform SD value 12% the mean was adopted as true varied non‐systematically between 9.1 and 12.4%. Applied to an unselected population 8663 singleton births, before 210 days gestation, 32% were classified...
Several trials evaluating the effect of prostate-specific antigen (PSA) testing on prostate-cancer mortality have shown conflicting results. We updated in European Randomized Study Screening for Prostate Cancer with 2 additional years follow-up.
Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use tumor markers in clinic have been developed.Published reports relevant to 5 cancer sites--testicular, prostate, colorectal, breast, and ovarian--were critically reviewed.For testicular cancer, alpha-fetoprotein, human chorionic gonadotropin, lactate dehydrogenase are recommended diagnosis/case finding, staging, prognosis determination, recurrence detection, therapy monitoring....
Immunologic measurements of the serum concentration prostate-specific antigen (PSA), an abundant prostatic-secreted serine proteinase, are frequently used to monitor patients with prostate cancer, though it has not been ascertained whether this immunoreactivity represents a PSA zymogen, active or complexed extracellular proteinase inhibitors. To characterize in serum, we monoclonal antibodies produced against and polyclonal rabbit IgG alpha 1-antichymotrypsin design three noncompetitive...
A 33-kD glycoprotein, known as the "prostate-specific antigen," was purified to homogeneity from human seminal plasma. The prostatic protein identified a serine protease, and its NH2-terminal sequence strongly suggests that it belongs family of glandular kallikreins. structural coagulum, predominant in vesicle secretion, rapidly cleaved by enzyme, which this may serve physiological substrate for protease. enzyme hydrolyzed arginine- lysine-containing substrates with distinct preference...
Prostate‐specific antigen (PSA) is one of the three most abundant prostatic‐secreted proteins in human semen. It a serine proteinase that, its primary structure, manifests extensive similarities with that Arg‐restricted glandular kallikrein‐like proteinases. When isolated from semen by addition chromatography on aprotinin‐Sepharose to previously described procedure, PSA displayed chymotrypsin‐like activity and cleaved semenogelin semenogelin‐related rapid characteristic pattern, but had no...
No AccessJournal of Urology1 Jul 1993Serum Prostate Specific Antigen Complexed to α1-Antichymotrypsin as an Indicator Cancer Anders christensson, Thomas Björk, Olle Nilsson, Ulrika Dahlén, Marja-Terttu Matikainen, Abraham T.K. Cockett, Per-Anders Abrahamsson, and Hans Lilja christenssonAnders christensson , BjörkThomas Björk NilssonOlle Nilsson DahlénUlrika Dahlén MatikainenMarja-Terttu Matikainen CockettAbraham Cockett AbrahamssonPer-Anders Abrahamsson LiljaHans View All Author...
Abstract Purpose: The development of tumor-specific markers to select targeted therapies and assess clinical outcome remains a significant area unmet need. We evaluated the association baseline circulating tumor cell (CTC) number with characteristics survival in patients castrate metastatic disease considered for different hormonal cytotoxic therapies. Experimental Design: CTC were isolated by immunomagnetic capture from 7.5-mL samples blood 120 progressive disease. estimated probability...
Purpose Prostate-specific antigen (PSA) defined biochemical recurrence (BCR) of prostate cancer is widely used for reporting the outcome radical prostatectomy (RP). A standardized BCR definition lacking, and overall progression-free probability risk subsequent metastatic disease progression may vary greatly depending on PSA criterion used. Ten definitions were evaluated to identify one that best explains progression. Methods Of 3,125 patients who underwent RP at our institution since 1985,...
A λgt11 clone encoding prostate specific antigen has been isolated from a human cDNA library. The insert of 1415 nucleotides hybridizes specifically to mRNA species 1.5 kb. nucleotide sequence codes for part signal peptide, short propiece and the mature protein 237 amino acid residues. M r non‐glycosylated was 26 089. One potential site N ‐linked carbohydrate attachment identified. primary structure shows extensive homology with proteases kallikrein family.
The comparison of measurements fibronectin and lactoferrin in ejaculates from vasectomized men, subjects with functional deficiency or aplasia the seminal vesicles, reference provided evidence that both human fluid originate vesicles ampullae. is incorporated framework gel formed during immediate postejaculatory phase, whereas remains solution. In linked to its predominant structural protein, a high molecular weight vesicle protein (semenogelin). Both gel-bound semenogelin are progressively...
Abstract Purpose: To better direct targeted therapies to the patients with tumors that express target, there is an urgent need for blood-based assays provide expression information on a consistent basis in real time minimal patient discomfort. We aimed use immunomagnetic-capture technology isolate and analyze circulating tumor cells (CTC) from small volumes of peripheral blood advanced prostate cancer. Experimental Design: Blood was collected 63 metastatic CTCs were isolated by Cell Search...
Circulating tumor cells (CTC) are shed in peripheral blood at advanced metastatic stages of solid cancers. Surface-marker-based detection CTC predicts recurrence and survival colorectal, breast, prostate cancer. However, scarcity variation size, morphology, expression profile, antigen exposure impairs reliable characterization CTC. We have developed a noncontact, label-free microfluidic acoustophoresis method to separate cancer from white (WBC) through forces generated by ultrasonic...
<b>Objective</b> To determine the association between concentration of prostate specific antigen (PSA) at age 40-55 and subsequent risk cancer metastasis mortality in an unscreened population to evaluate when start screening for whether rescreening could be stratified. <b>Design</b> Case-control study with 1:3 matching nested within a highly representative based cohort study. <b>Setting</b> Malmö Preventive Project, Sweden. <b>Participants</b> 21 277 Swedish men aged 27-52 (74% eligible...
Men with germline breast cancer 1, early onset (BRCA1) or 2, (BRCA2) gene mutations have a higher risk of developing prostate (PCa) than noncarriers. IMPACT (Identification genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium 62 centres 20 countries evaluating the use targeted PCa men mutations.
No AccessJournal of UrologyClinical Urology: Original Article1 Sep 1995Free, Complexed and Total Serum Prostate Specific Antigen: The Establishment Appropriate Reference Ranges for their Concentrations Ratios Joseph E. Oesterling, Steven J. Jacobsen, George G. Klee, Kim Petterson, Timo Piironen, Per-Anders Abrahamsson, Ulf-Hakan Stenman, Barry Dowell, Lovgren, Hans Lilja OesterlingJoseph Oesterling , JacobsenSteven Jacobsen KleeGeorge Klee PettersonKim Petterson PiironenTimo Piironen...