A5065954421- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Obesity, Physical Activity, Diet
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Coffee research and impacts
- Blood Coagulation and Thrombosis Mechanisms
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Child Nutrition and Feeding Issues
- Maternal and Perinatal Health Interventions
- Green IT and Sustainability
- Cardiac Structural Anomalies and Repair
- Neonatal Health and Biochemistry
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Pelvic floor disorders treatments
- Bladder and Urothelial Cancer Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Folate and B Vitamins Research
- Autoimmune and Inflammatory Disorders Research
- bioluminescence and chemiluminescence research
- Intestinal Malrotation and Obstruction Disorders
- Colorectal and Anal Carcinomas
- Sleep and related disorders
University of Oslo
2018-2023
Innlandet Hospital Trust
2019-2023
Inland Hospital
2010
University of Copenhagen
2002-2008
Rigshospitalet
2000-2006
Royal Agricultural University
2004
Copenhagen University Hospital
1999
Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use tumor markers in clinic have been developed.Published reports relevant to 5 cancer sites--testicular, prostate, colorectal, breast, and ovarian--were critically reviewed.For testicular cancer, alpha-fetoprotein, human chorionic gonadotropin, lactate dehydrogenase are recommended diagnosis/case finding, staging, prognosis determination, recurrence detection, therapy monitoring....
A kinetic enzyme-linked immunosorbent assay (ELISA) for plasma tissue inhibitor of metalloproteinase (TIMP)-1 was developed in order to examine the potential diagnostic and prognostic value TIMP-1 measurements cancer patients. The ELISA enabled specific detection total EDTA, citrate heparin plasma. rigorously tested requirements sensitivity, specificity, stability good recovery were fulfilled. levels measured (mean 69.2 ± 13.1 μg l–1) correlated with EDTA 73.5 14.2 from same individuals a...
Abstract Purpose: In the present study, we investigated association between tumor tissue levels of inhibitor metalloproteinase-1 (TIMP-1) and prognosis in patients with primary breast cancer analyzed whether TIMP-1 may be useful as a prognostic marker combination urokinase plasminogen activator (uPA) type-1 (PAI-1). Experimental Design: cytosolic extracts 2984 tumors, total were determined using an established, validated ELISA. Levels uPA PAI-1 have previously been extracts. Results:...
Only about 50% of metastatic breast cancer patients benefit from cytotoxic chemotherapy. Today, no validated markers exist for prediction chemotherapy sensitivity/resistance in this patient group. Tissue inhibitor metalloproteinases-1 (TIMP-1) has been shown to protect against apoptosis, and the purpose present study was test hypothesis that tumors expressing high levels TIMP-1 are protected apoptosis-inducing agents thus less sensitive chemotherapeutic drugs.We investigated association...
Energy drink (ED) consumption is increasing all over the world. We sought to describe of EDs among adolescents in Norway, and explore determinants daily high consumption.Population-based cross-sectional data were collected from a sample 31,091 secondary school students grade 8-13 aged 12-19 years. School grade, residency, socioeconomic status (SES), physical activity leisure screen time included multiple regression analyses, order investigate their associations with (≥four times weekly) ED...
The purpose of this study was to investigate the association between tumor tissue levels total inhibitor metalloproteinases-1 (TIMP-1) and prognosis in patients with primary breast cancer analyze whether measurement TIMP-1 extracts added prognostic information that obtained from measurements urokinase-type plasminogen activator type 1 (PAI-1). An established sandwich enzyme-linked immunosorbent assay thoroughly validated for used determine 341 detergent-extracted samples cancer. median age...
Abstract Background Adolescents are recommended to get 8–10 h of sleep at night, yet more than 80% fail obtain this goal. Energy drink (ED) consumption has been linked later bedtime in adolescents. Therefore, we aimed investigate the potential association between ED and duration, shuteye latency among adolescents Norway. Methods This study was based on data from 15- 16-year-old living Oppland County 2017. In total, 1353 were included analysis. Multiple regression models used estimate...
Abstract Tissue inhibitor of matrix metalloproteases 1 (TIMP‐1) inhibits the proteolytic activity and hereby prevents cancer invasion. However, TIMP‐1 also possesses other functions such as inhibition apoptosis, induction malignant transformation stimulation cell‐growth. We have previously demonstrated that is elevated in blood from colorectal patients high levels predict poor prognosis. To clarify role tumorigenesis, expression pattern benign tumors was studied. In all 24 cases...
Objectives To describe the social determinants and development in energy drink consumption among Norwegian adolescents 2017, 2018 2019. Design Cross-sectional, online, annual, nationwide surveys (Ungdata). Setting Responses collected online from January 2017 to December Participants Lower upper secondary school students (n=297 102) aged 12–19 years who responded Main outcome measures Frequency of consumption. Results Over 3-year period, 66.4% men 41.8% women had consumed once a week or more....
We previously found differences in total concentrations of tissue inhibitor metalloproteinases 1 (TIMP-1) plasma from donors and cancer patients. Because TIMP-1 can exist more than one molecular form, a new immunoassay to specifically detect free was developed were determined healthy colorectal (CRC) patients.We established validated an for the specific measurement that uses polyclonal anti-TIMP-1 antibody capture monoclonal binds only detection antigen. Plasma samples CRC patients assayed...
Crohn disease is considered a consequence of inappropriate upregulation immune reactions evoked by the intestinal microflora or luminal antigens. Since mucosa continuously exposed to tetanus toxoid we studied antibody response booster immunization in patients with and subsequent release various inflammatory mediators growth factors blood.Ten inactive no concurrent medication 12 age-and gender-matched healthy volunteers anti-tetanus levels less than 0.1 IU/ml were inoculated 1 ml (6 Lf units)...
The possible effect of preanalytical conditions such as blood sample preparation and handling on TIMP-1 levels in needs thorough investigation.Blood was collected dry tubes containing EDTA kept at 4 degrees C or 20 for 1, 3, 8, 24 72 hours before processing into serum plasma. In addition, plasma samples were frozen thawed 1-8 times. measured by ELISA.Time to up did not significantly affect serum. plasma, stable eight hours; however, if longer the increased (p < 0.0001). Repeated freezing...
The possible markers of liver fibrosis (plasma YKL-40, PIIINP, MMP-2 and TIMP-1) were measured at the start (t0) end treatment (t12) with alpha-interferon ribavirin repeated 6-months follow-up (t18) in 51 patients chronic hepatitis C.We evaluated 1) whether response is reflected by a decrease these during antiviral therapy; 2) reflect activity disease; 3) could be used as predictors response.Baseline plasma MMP-2, PIIINP TIMP-1 significantly increased compared to normal controls. In...
Background: There is a suggested coexistence between obesity and mental health discomfort in adolescence. The objective of this study was to explore if indices covaried with body mass index (BMI) adolescence there were gender-related disparities. Methods: Data collected two cross-sectional surveys 10th-grade students (15 16 years old) carried out 2002 2017. questionnaires included self-reported height weight, questions covering using the Strengths Difficulties Questionnaire (SDQ), lifestyle,...
This population-based, comprehensive, retrospective study presented the clinical outcomes of all children born in Norway between 2003 and 2017 with double outlet right ventricle (DORV).All DORV were identified Oslo University Hospital registry. Patients' characteristics, interventions, complications deaths recorded. Echocardiographic data reviewed for classification according to current standards. We investigated time-dependent surgical reintervention mortality using Kaplan-Meier analyses...
Iodine has an essential role in child growth and brain development. Thus, sufficient iodine intake is particularly important women of childbearing age lactating women.This cross-sectional study aimed to describe a large random sample mothers young children (aged ≤2 y) living Innlandet County, Norway.From November 2020 October 2021, 355 mother-child pairs were recruited from public health care centers. Dietary data obtained using two 24-h dietary recalls (24-HRs) per woman electronic FFQ. The...
Recommendations for sufficient vitamin D intake in children were recently revised Norway. However, optimal levels of are still debated and knowledge on supplementation healthy Norway is scarce. Therefore, we measured the plasma-concentration 25-hydroxyvitamin (25(OH)D) adolescents attending outpatient paediatric clinics Innlandet Hospital Trust, during two consecutive years (2015–2017). We recruited 301 aged 5 months to 18 (mean 7.8, SD 4.4 years) study obtained sample material 25(OH)D...
Obstetric anal sphincter injury (OASI) is a common and severe complication of vaginal delivery may have short- long-term consequences, including incontinence, sexual dysfunction reduced quality life. The rate OASI varies substantially between studies national birth statistics, recent meta-analysis concluded that there need to identify unrecognized risk factors. Our aim was therefore explore both potential modifiable non-modifiable factors for OASI.We performed case-control study in single...
Background The possible effect of preanalytical conditions such as blood sample preparation and handling on TIMP-1 levels in needs thorough investigation. Materials Methods Blood was collected dry tubes containing EDTA kept at 4°C or 20°C for 1, 3, 8, 24 72 hours before processing into serum plasma. In addition, plasma samples were frozen thawed 1–8 times. measured by ELISA. Results Time to up did not significantly affect serum. plasma, stable eight hours; however, if longer the increased...