A5102965441- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Central Venous Catheters and Hemodialysis
- Infant Development and Preterm Care
- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Family and Disability Support Research
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Cardiovascular and Diving-Related Complications
- Cardiovascular Effects of Exercise
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Function and Risk Factors
- Cardiovascular Conditions and Treatments
- Vascular anomalies and interventions
- Adolescent and Pediatric Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Infective Endocarditis Diagnosis and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiac Arrest and Resuscitation
- Family Support in Illness
Oslo University Hospital
2015-2025
University of Oslo
2010-2025
Sørlandet Hospital Arendal
2019
Sørlandet Sykehus
2019
Smerteklinikken
2019
Norwegian Institute of Public Health
2010-2013
Med-Storm Innovation (Norway)
2000-2007
National Hospital
2005
Hospital IT
2005
Tulane University
1991
Central venous lines (CVLs) are essential in the care of children with malignancies, but associated thromboembolism (VTE) and infections. Effective safe prophylactic approaches deficient.To perform a study adjusted low-dose warfarin for prevention CVL-related VTE malignancies.Children newly diagnosed cancer, CVL jugular vein an expected treatment period over 6 mo were eligible study. Participants randomized to warfarin, intended international normalized ratio (INR) 1.3-1.9, or control group....
Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction an emphasis on specialist follow-up. The aim of this study was to determine cause-specific mortality ES evaluate any relevant changes between 1977 2015.This a retrospective, descriptive multicentre study. A total 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included. Cause-specific examined before after July...
Objective To examine the relationship between severity of infants' congenital heart defects (CHD) and their mothers' symptoms depression anxiety from pregnancy to 18 months postpartum. Methods Mothers infants with mild, moderate, or severe CHD (n = 162) mothers 44 400) within Norwegian Mother Child Cohort Study were assessed an eight-item short version (SCL-8) Hopkins Symptom Checklist-25 at 30th week gestation 6 Results Only postpartum mental health trajectory deviated cohort postpartum,...
<h3>Objectives</h3> Congenital heart defects (CHD) are the most common birth worldwide and an important cause of morbidity early death. A significant number deaths occur among patients with infections. CHDs predispose to development infective endocarditis (IE) represent a risk factor for increased mortality due IE. The aim this study was investigate occurrence outcomes IE in children adolescents CHDs. <h3>Methods</h3> Data on all CHD born Norway between 1994 2016 were retrieved from Oslo...
This study was designed to prospectively evaluate the prevalence of thrombophilia and central venous catheter-associated neck vein thrombosis in children with cancer.Children cancer lines, treated at National Hospital Norway, were consecutively enrolled study. Biochemical analysis Doppler ultrasonography veins performed inclusion, repeated 3-5 months later. We recorded systematically positive blood-cultures days intravenous antibiotics. In a subgroup 13 patients acute lymphoblastic...
Objective To chart mothers' trajectories of mental health from pregnancy to 36 months postpartum in order investigate the association between infants' congenital heart defects (CHD) and compromised maternal health. Methods Mothers infants with mild, moderate, or severe CHD (n = 141) mothers 36,437) enrolled Norwegian Mother Child Cohort Study were assessed at regular intervals up postpartum, including measurements 6 18 months, using an 8-item version Hopkins Symptom Checklist-25. Results...
Background and aims Severe congenital heart defects (CHDs) still represent one of the main causes infant death. The risk factors associated with cardiac surgery postoperative mortality are well known. We aimed to describe rates, time trends before surgery—including termination pregnancies palliative care—in fetuses children below 2 years age severe CHDs. Methods results Data concerning all 789 345 in Norway from 2004 2016 were retrieved Medical Birth Registry Norway, Oslo University...
Abstract Aim The aims of this nationwide retrospective cohort study were to determine the time and causes detection severe congenital heart defects (CHDs) in live‐born infants Norway between 2017 2020. Methods Information regarding with CHDs was retrieved from national registries medical records. Results A total 219 776 born 01.01.2017 31.12.2020. Severe diagnosed 442 (0.2%) infants. Of these, 376 (85%) either prenatally ( n = 203, 46%) or before discharge hospital after birth 173, 39%). 56...
Abstract Background: The frequency of asymptomatic central line‐associated thromboses is high and well recognized among children with cancer, while the long‐term consequences are mainly unknown. Aim: In a cross‐sectional study, we evaluated clinical radiological venous outcome in previous long‐standing intravascular catheters. Methods: study enrolled 71 previously treated for malignant or haematological diseases, 4–180 (median 37) mo after removal their lines. Inclusion criteria were prior...
Patients with Fontan circulation are at risk of developing hepatic fibrosis/cirrhosis. The mechanisms and disease development unclear early secondary liver cancer is a concern. This study will describe imaging findings in national cohort adolescents circulation.The patients prospectively underwent abdominal contrast enhanced magnetic resonance (MRI) including diffusion-weighted imaging. Images were assessed for criteria fibrosis/cirrhosis characterization nodules. These nodules addition, by...
BackgroundPatients with Jervell and Lange-Nielsen syndrome (JLNS) exhibit severe phenotypes that are characterized by congenital deafness, very long QT intervals, high risk of life-threatening arrhythmias. Current treatment strategies include doses beta-blocker medication, left cardiac sympathetic denervation, ICD placement, which is challenging in young children.ObjectiveThe purpose this study was to evaluate the safety effect pacing addition children JLNS.MethodsAll genetically confirmed...
Thrombophilia screening is a time-consuming and expensive procedure. Information about thromboembolism among relatives may be simple method to identify those at risk of having thrombophilia. In cross-sectional clinical study the authors have investigated role such family histories detect children with 202 history venous or arterial was recorded. The participants were either congenital heart defects time scheduled cardiac catheterization (n = 134) newly diagnosed cancer 68). Questions...
Background With the advances in congenital cardiac surgery and medical management, mortality rates for heart defects (CHD) have declined remarkably. As number of CHD survivors increased there is a growing focus on developmental morbidity. The objective current study to compare symptoms communication social impairment 18-month-old children with different severity those controls. Method We linked prospective data from Norwegian Mother Child Cohort Study, conducted by Institute Public Health,...
Taking care of a child with special needs can be draining and difficult require lot parental time resources. The present study investigated the long-term sickness absence parents who have children spina bifida, cerebral palsy Down syndrome compared to that without needs.The sample consisted primiparae women gave birth between 2001 2005 fathers (N = 202,593). Data were obtained from Medical Birth Registry Norway (MBRN), which is linked Central Population Register, education income registries...
Clinical management of warfarin therapy is complex, and dosing algorithms do not include genetic factors or interactions with other drugs for dose determinations. We evaluated the interaction CYP2C9 polymorphisms concomitant corticosteroids in 29 children cancer. Children heterozygous achieved target INR sooner more frequently had above level, compared to without mutations. on steroids significantly lower requirements. Thus, awareness genotype steroid-induced responsiveness may be important...
Abstract Introduction: The aim of this prospective study was to determine the frequency and composition cerebral microemboli in a paediatric population during transcatheter atrial septal defect closure. Methods: Multi-frequency transcranial Doppler used detect microembolic signals middle artery 24 patients. Embolic were automatically identified differentiated according their composition, gaseous or solid. procedure divided into five periods: right cardiac catheterisation; left pulmonary...
Asparaginase is essential in the treatment of lymphoproliferative malignancies, but it associated with several side effects. The objective this study was to compare asparaginase-induced alterations coagulation inhibitors and impact on central line-associated thrombosis children treated according 2 different asparaginase regimens. enrolled 30 for acute lymphoblastic leukemia, they were divided into groups respect preparation protocol (NOPHO ALL-1992 versus NOPHO ALL-2000). antithrombin,...
Advances in medical treatment recent years have led to dramatically improved survival rates of children with severe congenital heart defects (CHD). However, very little is known about the psychological consequences for these children, particularly during and after early period invasive treatment. In this study, we investigated extent which severity CHD affects child's emotional reactivity at 6 months age.We linked prospective data from Norwegian Mother Child Cohort Study, conducted by...