A5076001861- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Nonmelanoma Skin Cancer Studies
- CAR-T cell therapy research
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Head and Neck Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Optical Coherence Tomography Applications
- Cancer and Skin Lesions
- Ear and Head Tumors
- Breast Implant and Reconstruction
- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- AI in cancer detection
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Antenna Design and Analysis
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
University of Alabama at Birmingham
2010-2023
American Association of Neurological Surgeons
2016-2023
The University of Texas MD Anderson Cancer Center
1993-2016
Roswell Park Comprehensive Cancer Center
1993-2016
University of Louisville
2006-2016
Dallas Surgical Group
2006-2016
Huntsman Cancer Institute
2016
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2016
University Hospitals Seidman Cancer Center
2016
University of Colorado Denver
2016
PURPOSE: The American Joint Committee on Cancer (AJCC) recently proposed major revisions of the tumor-node-metastases (TNM) categories and stage groupings for cutaneous melanoma. Thirteen cancer centers cooperative groups contributed staging survival data from a total 30,450 melanoma patients their databases in order to validate this proposal. PATIENTS AND METHODS: There were 17,600 with complete clinical, pathologic, follow-up information. Factors predicting melanoma-specific rates analyzed...
A prospective multi-institutional randomized surgical trial involving 740 stage I and II melanoma patients was conducted by the Intergroup Melanoma Surgical Program to determine whether elective (immediate) lymph node dissection (ELND) for intermediate-thickness (1-4 mm) improves survival rates compared with clinical observation of nodes. second objective define subgroups who would have a higher ELND.The eligible were stratified according tumor thickness, anatomic site, ulceration, then...
Although wide surgical excision is the accepted treatment for thin malignant melanomas, there reason to believe that narrower margins may be adequate. We conducted a randomized prospective study assess efficacy of narrow (excision with 1-cm margins) primary melanomas no thicker than 2 mm. Narrow was performed in 305 patients, and (margins 3 cm or more) 307 patients. The major prognostic criteria were well balanced two groups. mean thickness 0.99 mm narrow-excision group 1.02 wide-excision...
Background: A prospective, multi-institutional, randomized surgical trial involving 486 localized melanoma patients was conducted to determine whether excision margins for intermediate-thickness melanomas (1.0 4.0 mm) could be safely reduced from the standard 4-cm radius. Methods: Patients with 1− 4-mm-thick on trunk or proximal extremities were randomly assigned receive either a 2− margin. Results: The median follow-up time 6 years. local recurrence rate 0.8% 2-cm and 1.7% (p value not...
In this review of a collected series patients undergoing hepatic resection for colorectal metastases, 100 were found to have survived greater than five years from the time resection. Of these long-term survivors, 71 remain disease-free through last follow-up, 19 recurred prior years, and ten after years. Patient characteristics that may contributed survival examined. Procedures performed included trisegmentectomies, 32 lobectomies, 16 left lateral segmentectomies, 45 wedge resections. The...
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Melanoma focuses on adjuvant therapy and treatment of in-transit disease, because substantial changes were made to recommendations 2016 update. Depending stage options now include biochemotherapy high-dose ipilimumab. Treatment disease intralesional injection with talimogene laherparepvec (T-VEC), a new immunotherapy. These additions prompted re-assessment data supporting older recommended resulting...
Basal cell carcinoma (BCC) of the skin is most common cancer, with a higher incidence than all other malignancies combined. Although it rare to metastasize, patients multiple or frequently recurring BCC can suffer substantial comorbidity and be difficult manage. Assessment risk key element management needed inform treatment selection. The overall primarily consists surgical approaches, radiation therapy as an alternate adjuvant option. Many superficial therapies for have been explored...
Grotting, James C. M.D.; Urist, Marshall M. Maddox, William A. Vasconez, Luis O. M.D. Author Information
To examine the incidence of local recurrence (LR) and factors associated with it in a population patients who underwent skin-sparing mastectomy (SSM) immediate reconstruction for invasive carcinoma.The efficacy SSM has been challenged by concerns about increased risks LR.A consecutive series 173 (176 cancers) carcinoma breast (June 1986 to December 1997). Data were analyzed Kaplan-Meier method, log-rank statistic test, Cox proportional hazards model.Mean patient age was 47 +/- 9 years (27%...
A prospective phase II evaluation of regional FUDR chemotherapy using a totally implantable drug infusion pump was conducted in 81 patients with colorectal metastases to the liver. The survival results were compared historical control group 129 isolated liver metastases. two groups comparable respect their dominant prognostic factors. received continuous on an outpatient basis and had 88% response rate, as evidenced by fall serum CEA levels one-third or greater after cycles chemotherapy. By...
Single and multifactorial analyses were used to evaluate prognosis results of surgical treatment in 534 clinical Stage I patients with head neck cutaneous melanoma treated at the University Alabama Birmingham (U.S.A.) Sydney (Australia). This computerized data base was prospectively accumulated over 90% cases. Melanomas about equally distributed between men women. They located on skin face 47%, 27%, scalp 13%, ear 13% patients. Both prognostic factors demonstrated that lentigo maligna (LMM)...
Sera from 517 patients with various types of malignancies were assayed for immune complexes (ICs) by the Raji cell radioimmune assay. The incidence in these ranged 16 to 52% as compared 19% normal controls. Increases tumor mass and metastatic disease associated high levels circulating ICs. Immunization melanoma BCG tumor-cell vaccine produced an increase Cancer sera contained intermediate size. Tumor antigens IgG, presumably form complexes, identified immunofluorescence radiolabeled antibody...
To better understand the factors associated with well-established gender difference in survival for patients melanoma.Gender is an important factor cutaneous melanoma. Male have a worse outcome when compared females. The reasons this are poorly understood.This prospective multi-institutional study included aged 18 to 70 years melanomas > or =1.0 mm Breslow thickness. Wide excision and sentinel lymph node (SLN) biopsy was performed all patients. Clinicopathologic factors, including gender,...
Risk factors associated with local recurrences were analyzed from a series of 3445 clinical Stage I melanoma patients. In single-factor analysis, tumor thickness, ulceration, and increasing age highly significantly predictive recurrence (p < 0.00001). After 5 years follow-up, rates 0.2% for tumors less than 0.76 mm thick, 2.1% to 1.49 6.4% 1.5 3.99 13.2% 4.0 or greater in thickness. Ulcerated melanomas recurred more often nonulcerated lesions (11.5% versus 1.9%). When as continuous variable,...
Our experience with 294 regional lymph node dissections in 250 patients are reviewed. The relationship between the Clark's level of invasion and thickness primary is related to metastases. Patients Level III melanoma had a 29% incidence metastases, IV 42% metastases V 58% Primary melanomas greater than 1.5 mm 38% positive nodes. We therefore recommend lymphadenectomy Levels III, all that thickness. A new technique described which helpful localizing direction ambiguous lymphatic drainage...
A series of 204 melanoma patients were studied six months or longer after regional lymph node dissection the neck (N = 48), axilla 98) and groin 58) in order to determine degree morbidity analyze for risk factors associated with these procedures. Only one-quarter experienced wound-related, short-term complications that common at all sites; however, rarely resulted long-term functional deficits. Seromas (22%), temporary nerve dysfunction pain (14%), wound infections (6%) most frequent...
The NCCN Guidelines for Melanoma provide multidisciplinary recommendations on the clinical management of patients with melanoma. This Insights report highlights notable recent updates. Foremost these is exciting addition novel agents ipilimumab and vemurafenib treatment advanced panel also included imatinib as a KIT-mutated tumors pegylated interferon alfa-2b an option adjuvant therapy. Also important are revisions to initial stratification early-stage lesions based risk sentinel lymph node...
The NCCN Guidelines for Melanoma have been significantly revised over the past few years in response to emerging data on a number of novel agents and treatment regimens. These Insights summarize rationale supporting extensive changes recommendations systemic therapy patients with metastatic or unresectable melanoma.