A5100652764- Cutaneous Melanoma Detection and Management
- Emergency and Acute Care Studies
- Cystic Fibrosis Research Advances
- Liver Disease and Transplantation
- Liver physiology and pathology
- Sphingolipid Metabolism and Signaling
- Sepsis Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Breast Lesions and Carcinomas
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Cancer Immunotherapy and Biomarkers
- Healthcare Systems and Technology
- AI in cancer detection
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Airway Management and Intubation Techniques
- Liver Disease Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Melanoma and MAPK Pathways
- Cancer Diagnosis and Treatment
- Respiratory viral infections research
- Stress Responses and Cortisol
- Organ Transplantation Techniques and Outcomes
- Asthma and respiratory diseases
Adelphi Group (United Kingdom)
2024
University of Duisburg-Essen
2023
Institute of Molecular Biology
2023
Stanford Medicine
2022
Flinders Medical Centre
2022
University of Cincinnati
2010-2021
Pfizer (United States)
2021
Imperial College London
2012-2021
Wirral University Teaching Hospital NHS Foundation Trust
2019-2020
University of Cincinnati Medical Center
2010-2019
A sentinel lymph node is the first to receive lymphatic drainage from a tumor. It can be detected by injection of blue dye or radioactive colloid around primary tumor, which travels and identifies draining (sentinel) node. Biopsy reveal whether there are metastases, thereby obviating need for extensive dissection regional lymph-node basin. Sentinel-lymph-node biopsy has become standard technique determining nodal stage disease in patients with melanoma. Initial studies this method breast...
To better understand the factors associated with well-established gender difference in survival for patients melanoma.Gender is an important factor cutaneous melanoma. Male have a worse outcome when compared females. The reasons this are poorly understood.This prospective multi-institutional study included aged 18 to 70 years melanomas > or =1.0 mm Breslow thickness. Wide excision and sentinel lymph node (SLN) biopsy was performed all patients. Clinicopathologic factors, including gender,...
Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients cystic fibrosis (CF). We observed that β1-integrins accumulate on luminal membrane upper-airway epithelial cells from mice humans CF. β1-integrin accumulation due to increased ceramide formation platforms trap pole bronchial cells. downregulate acid ceramidase expression, resulting further consequent reduction surface sphingosine, a lipid...
The acid sphingomyelinase/ceramide system has been shown to be important for cellular infection with at least some viruses, instance, rhinovirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Functional inhibition of the sphingomyelinase using tricyclic antidepressants prevented epithelial cells, instance SARS-CoV-2. structure ambroxol, that is, trans-4-[(2,4-dibromanilin-6-yl)-methyamino]-cyclohexanol, a mucolytic drug applied by inhalation, suggests might inhibit and...
To evaluate the prognostic significance of molecular staging using reverse transcriptase polymerase chain reaction (RT-PCR) in detecting occult melanoma cells sentinel lymph nodes (SLNs) and circulating bloodstream.In this multicenter study, eligibility criteria included patient age 18 to 71 years, invasive > or = 1.0 mm Breslow thickness, no clinical evidence metastasis. SLN biopsy wide excision primary tumor were performed. SLNs examined by serial-section histopathology S-100...
Background: Pulmonary Staphylococcus aureus (S. aureus) infections occur early in a high percentage of cystic fibrosis (CF) patients and it is believed that these facilitate further colonization CF lungs with Pseudomonas aeruginosa (P. aeruginosa). Previous studies demonstrated marked reduction sphingosine tracheal bronchial epithelial cells compared to wild type mice, while ceramide massively increased mice. Methods: We investigated the effect C18-sphingosine C16-ceramide on S. vitro. Based...
Background: Cystic fibrosis (CF), the most common autosomal recessive disorder in Western countries, is characterized by chronic pulmonary inflammation, reduced mucociliary clearance, and increased susceptibility to infection. Our studies using Cftr-deficient mice human CF specimens showed that ceramide accumulates lungs mediates cell death, infections, inflammation. Methods: We used syngenic wildtype as well heterozygous for acid sphingomyelinase. determined activation topology of...
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Background/Aims: Glioblastoma (GBM) is one of the most aggressive cancers, counting for a high number newly diagnosed patients with central nervous system (CNS) cancers in United States and Europe. Major features GBM include invasive growth as well resistance to treatment. Kv1.3, potassium channel shaker family, expressed inner mitochondrial membrane many cancer cells. Inhibition Kv1.3 was shown induce apoptosis several tumor cells at doses that were not lethal normal Methods: We...
Both the initial trauma and subsequent hemodynamic instability may contribute to intestinal damage, which is of great importance in (immunological) posttrauma complications. This study assesses damage using biomarker Fatty Acid Binding Protein (iFABP) patients during first days their hospital admission risk factors involved. Plasma iFABP levels were measured blood samples obtained from adult multiple (n = 93) at scene by Helicopter Emergency Medical Services, arrival emergency department...
To influence self-referral, it is crucial to know a patient’s motives directly visit the emergency department (ED). The goal of this study examine for self-referral ED and compare these in relation appropriateness. All self-referred patients visiting Dutch hospital over four separate months 1-year period were included. Patients handed questionnaires that included questions on their reasons where they would seek medical help next time. Additionally, either appropriately or inappropriately...
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin soft-tissue to severe even lethal such as pneumonia, endocarditis, sepsis, osteomyelitis, toxic shock syndrome. Toxins that released S. mediate many of these effects. Here, we aimed identify molecular mechanisms how α-toxin, toxin, induces inflammation. Methods: Macrophages were isolated the bone marrow wildtype acid sphingomyelinase-deficient mice, stimulated with α-toxin...