A5062982351- Cutaneous Melanoma Detection and Management
- Photochromic and Fluorescence Chemistry
- Melanoma and MAPK Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Nonmelanoma Skin Cancer Studies
- Chemical Synthesis and Analysis
- bioluminescence and chemiluminescence research
- Receptor Mechanisms and Signaling
- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Protein Kinase Regulation and GTPase Signaling
- Computational Drug Discovery Methods
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Click Chemistry and Applications
- Cancer Cells and Metastasis
- Cutaneous lymphoproliferative disorders research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Optical Coherence Tomography Applications
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
Rutgers Cancer Institute of New Jersey
2009-2023
Rutgers, The State University of New Jersey
2010-2023
Johnson University
1999-2023
Brunswick (United States)
2003-2019
Cancer Institute of Florida
1999-2018
University of Louisville
2006-2016
Dallas Surgical Group
2006-2016
Rutgers Sexual and Reproductive Health and Rights
2011
Rutgers New Jersey Medical School
2010
Robert Wood Johnson University Hospital
2009
Abstract The Sunbelt Melanoma Trial is an ongoing multicenter prospective randomized trial that involves 79 centers and over 3600 patients from across the United States Canada. This one of first large studies to incorporate molecular staging using reverse transcriptase polymerase chain reaction (RT‐PCR). While results related primary endpoints study are not yet available, several analyses have shed light on many aspects sentinel lymph node (SLN) biopsy melanoma prognostic factors. In...
The immediate molecular mechanisms behind invasive melanoma are poorly understood. Recent studies implicate microRNAs (miRNAs) as important agents in and other cancers. To investigate the role of miRNAs melanoma, we subjected human cell lines to miRNA expression profiling, report a range variations several miRNAs. Specifically, compared with levels melanocytes, miR-211 were consistently reduced all eight non-pigmented examined; they also 21 out 30 distinct samples from patients, classified...
To better understand the factors associated with well-established gender difference in survival for patients melanoma.Gender is an important factor cutaneous melanoma. Male have a worse outcome when compared females. The reasons this are poorly understood.This prospective multi-institutional study included aged 18 to 70 years melanomas > or =1.0 mm Breslow thickness. Wide excision and sentinel lymph node (SLN) biopsy was performed all patients. Clinicopathologic factors, including gender,...
Abstract Purpose: Activation of the mitogen-activated protein kinase (MAPK) pathway and phosphatidylinositol 3-kinase/AKT seems to be critical for melanoma proliferation. Components these pathways are client proteins heat-shock 90 (hsp90), suggesting that inhibition hsp90 could have significant antimelanoma effects. We conducted a phase II trial using inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) in patients. The primary end points were clinical responses whether treatment...
Abstract Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies these mice identified aberrant expression metabotropic receptor 1 (GRM1) melanocytes played critical role onset melanoma. Confirmation etiologic GRM1 development was shown second line with under regulation melanocyte-specific dopachrome tautomerase promoter....
Store-operated Ca2+ entry (SOCE) is a major mechanism of import from extracellular to intracellular space, involving detection store depletion in endoplasmic reticulum (ER) by stromal interaction molecule (STIM) proteins, which then translocate plasma membrane and activate Orai channels there. We found that STIM1 Orai1 isoforms were abundantly expressed human melanoma tissues multiple melanoma/melanocyte cell lines. confirmed these lines exhibited SOCE, was inhibited knockdown or Orai1,...
Objective To determine if the serum level of interleukin-6 (IL-6) was elevated in patients with hepatic malignancies or correlated radiologic tumor burden. Summary Background Data High levels IL-6 signify an adverse prognosis many cancer. is a growth factor for bile duct epithelium. Methods Using bioactive and enzyme-linked immunosorbent assays, measured 35 healthy adults 60 presenting definitive management cholangiocarcinoma (CC) (15 patients), hepatocellular carcinoma (HCC) (14),...
To evaluate the prognostic significance of molecular staging using reverse transcriptase polymerase chain reaction (RT-PCR) in detecting occult melanoma cells sentinel lymph nodes (SLNs) and circulating bloodstream.In this multicenter study, eligibility criteria included patient age 18 to 71 years, invasive > or = 1.0 mm Breslow thickness, no clinical evidence metastasis. SLN biopsy wide excision primary tumor were performed. SLNs examined by serial-section histopathology S-100...
The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability with concomitant effect on HIF-1alpha availability. Because is implicated in tumorigenesis and metastasis, we used SW1 mouse melanoma cells, which develop primary tumors a propensity metastasize, syngeneic model assess possible role for these processes. Inhibiting activity by expressing peptide designed outcompete association of Siah2-interacting proteins reduced metastasis through without affecting...
Ectopic expression of GRM1 in murine melanocytes results transformation into a form melanoma, and more than 60% human melanoma samples tested ectopically express GRM1. Stimulation this receptor vitro up-regulation activated extracellular signal-regulated kinase (ERK). Furthermore, xenograft model treated with riluzole, an oral blocking agent, showed decreased tumor growth compared the untreated controls. We have now completed phase 0 trial riluzole patients melanoma.Patients enrolled on...
The Sunbelt Melanoma Trial is a prospective randomized trial evaluating the role of high-dose interferon alfa-2b therapy (HDI) or completion lymph node dissection (CLND) for patients with melanoma staged by sentinel (SLN) biopsy.Patients were eligible if they age 18 to 70 years primary cutaneous ≥ 1.0 mm Breslow thickness and underwent SLN biopsy. In Protocol A, single tumor-positive after biopsy CLND randomly assigned observation versus HDI. B, tumor-negative standard histopathology...
Melanoma has a poor prognosis due to its strong metastatic ability. Although Ca(2+) plays major role in cell migration, little is known about the of melanoma migration. We recently found that exchange protein directly activated by cyclic AMP (Epac) increases migration via heparan sulfate-related mechanism. In addition this mechanism, we also Epac regulates Ca(2+)-dependent An agonist increased several different lines but not melanocytes. Ablation Epac1 with short hairpin RNA inhibited...
Cancer is a leading cause of death men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority cancer deaths. Extracellular receptors modified by α2,3-sialic acids promote this can serve as ideal chemotherapeutic targets. For example, extracellular domain mucin receptor podoplanin (PDPN) highly O-glycosylated with acid linked galactose. PDPN activated endogenous ligands induce tumor metastasis. Dietary lectins target proteins containing...
Our research group demonstrated that riluzole, an inhibitor of glutamatergic signaling reduced melanoma cell proliferation in vitro and tumor progression vivo. The underlying mechanisms riluzole are largely unknown. Microarray analyses on two human lines revealed stimulates expression the cystine-glutamate amino acid antiporter, xCT (SLC7A11). Western immunoblot analysis from cultured or normal melanocytic cells showed was significantly overexpressed most melanomas, but not cells. Studies...
Many melanoma patients do not regularly perform thorough skin self-examinations. We examined the extent to which conduct self-examination, how they and their related knowledge self-efficacy. A sample of 176 individuals (61.5% response rate) diagnosed with primary pathologic stage 0-III cutaneous malignant at a single cancer center completed written or telephone survey regarding self-examination behaviors associated factors. Almost all participants (98.9%) reported race as white....
Summary Studies demonstrate that GRM , expressed by >60% of human melanomas, may be a therapeutic target. We performed phase II trial 100 mg PO bid riluzole, an inhibitor 1 signaling, in patients with advanced melanoma the primary endpoint response rate. Thirteen 1‐positive tumors were enrolled. No objective responses observed, and accrual was stopped. Stable disease noted six (46%) patients, one patient on study for 42 weeks. Riluzole well tolerated, fatigue (62%) as most common adverse...